Universal reference book for medicines
Product name: OKI

Active substance: ketoprofen

Type: NSAIDs for topical application in ENT practice and dentistry

Manufacturer: DOMPE FARMACEUTICI (Italy)
Composition, form of production and packaging
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The solution for topical application is transparent, green, with a characteristic smell of mint .
1 ml

ketoprofen lysine salt 16 mg

Auxiliary substances: glycerol - 200 mg, ethanol - 0.05 ml, methyl p-hydroxybenzoate - 1.5 mg, mint flavor - 3 mg, menthol - 0.7 mg, sodium saccharin - 2 mg, "Verde Chitose" (brilliant green) - 0.16 mg , sodium hydrophosphate - 22 mg, purified water - 1 ml.

150 ml - plastic bottles (1) with plastic cover, protected from opening by children, complete with a measuring cup 10 ml - packs cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2016.

PHARMACHOLOGIC EFFECT

NSAIDs.
Has anti-inflammatory, analgesic and antipyretic effect. Inhibiting COX-1 and COX-2, inhibits the synthesis of prostaglandins. It has anti-bradykinin activity, stabilizes lysosomal membranes, and delays the release of enzymes that promote tissue destruction in chronic inflammation. Reduces the secretion of cytokines, inhibits the activity of neutrophils.
The drug does not have antibacterial action.

PHARMACOKINETICS

After using ketoprofen lysine salt as a topical solution at a dose of 160 mg, the concentration of ketoprofen in the plasma is very low (less than 400 ng / ml) and, consequently, insufficient for a pronounced systemic action.

INDICATIONS

Symptomatic treatment of inflammatory diseases of ENT organs and oral cavity, including:

- angina;

pharyngitis;

- laryngitis;

- tonsillitis;

- stomatitis;

- gingivitis;

- glossitis;

- aphthae;

- parodontopathy;

- chronic periodontitis.

As an analgesia in dental manipulations.

DOSING MODE

The drug is used topically as a rinse.

Adults should take 2 rinses / day.
For 1 rinse, use 10 ml of Oka solution. Teenagers over 12 years of age should not use more than 6 ml per rinse.
10 ml of the rinse solution should be measured with a cup attached to the package and diluted in 100 ml (half a glass) of drinking water.

SIDE EFFECT

Possible: allergic reactions.

If the product is swallowed, systemic side effects may develop.

CONTRAINDICATIONS

- "aspirin" asthma;

- Hypersensitivity to ketoprofen or other NSAIDs.

With caution , the drug should be used for peptic ulcer disease of the stomach and duodenal ulcer in the exacerbation phase, ulcerative colitis in the acute phase, Crohn's disease, diverticulitis, peptic ulcer, hemophilia and other disorders of blood clotting, chronic renal failure, in the third trimester of pregnancy, during lactation breastfeeding), as well as in children under the age of 6 years.

PREGNANCY AND LACTATION

The use of the drug in the III trimester of pregnancy is not recommended.
In the first and second trimesters of pregnancy, Oki should be used with caution and under the supervision of a doctor.
If you need to use the drug during lactation, breastfeeding should be discontinued.

APPLICATION FOR FUNCTIONS OF THE LIVER

Caution should be applied to the drug in chronic kidney failure.

APPLICATION FOR CHILDREN

With caution should be used in children under the age of 6 years.

SPECIAL INSTRUCTIONS

Prolonged use of the drug may lead to sensitization.
In this case, the drug should be discontinued and appropriate treatment methods should be selected.
Accidental ingestion of the rinse solution does not lead to serious consequences, because
a single dose for rinsing contains 160 mg of ketoprofen lysine salt, which corresponds to a dose intended for oral administration.
OVERDOSE

At present, cases of Oka overdose have not been reported.

DRUG INTERACTION

Drug interaction of Oka was not detected.

TERMS OF RELEASE FROM PHARMACY

The drug is approved for use as a means of OTC.

TERMS AND CONDITIONS OF STORAGE

The drug should be stored out of the reach of children at a temperature of no higher than 25 ° C.
Shelf life - 2 years.
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