Universal reference book for medicines
Name of the drug: NEUROPHAZOL (NEUROPHAZOL)

Active substance: fabomotizole

Type: Tranquilizer (anxiolytic)

Manufacturer: ЛЕККО (Russia)
Composition, form of production and packaging
Concentrate for solution for infusion
1 ml 1 fl.

morpholinoethylthioethoxybenzimidazole dihydrochloride 5 mg 10 mg

2 ml - bottles of dark glass (1) - packaging contour plastic (5) - packs cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2010.

PHARMACHOLOGIC EFFECT

Neurophasol possesses neuroprotective properties.
The mechanism of action of Neurophazole is due to the interaction with sigma 1 -receptors, through which the phospholipid framework of the receptor structures of the cell surface is restored; normalization of the calcium balance; counteracting glutamate excitotoxicity and increased production of nitric oxide; restoration of the deficit of nerve growth factors. Neurophazole improves the survival of neurons and reduces the severity of cytotoxic reactions in the damaging effects of oxidative stress and glutamate, normalizes the level of cannase-3, one of the main enzymes activated by apoptosis. The drug has a stimulating effect on the formation of neurotrophic brain factors - NGF (nervegrowth-factor, nerve growth factor) and BDNF (brain-derivedneurotrophic-factor - cerebral neurotrophic factor).
The drug has a protective effect on cells of the penumbra zone in conditions of local ischemia, reduces the severity of post-insult disorders and accelerates the restoration of neurologic functions.
In cerebral ischemia, Neurophazole suppresses the NO-synthase pathway of formation of nitric oxide in neurons of the brain, prevents the increase of NO-synthase activity. It causes an improvement in energy metabolism, restoring the activity of succinate dehydrogenase in brain ischemia.Promotes increased cerebral blood flow in ischemic conditions, without affecting systemic blood pressure. The participation of GABA-ergic system in the implementation of cerebrovascular and neuroprotective action of the drug was established.
PHARMACOKINETICS

T 1/2 of Neurophazole is 0.82 hours. The rate of elimination from plasma is 2.12 h -1 .
The concentration of the drug in the blood plasma increases in proportion to the increase in the dose of Neurophazole. After iv introduction quickly captured by cells of different organs and tissues. Well penetrates the blood-brain barrier. According to experimental data, it undergoes intensive metabolism in the liver. It is excreted from the body mainly in the form of metabolites. 24 hours after the administration unchanged in the urine 0.07% is recorded, in the feces 0.05% of the administered dose.
INDICATIONS

- Brain infarction (ischemic stroke).

DOSING MODE

Neurophazole is used as part of complex therapy in the form of IV infusion drops 10 mg twice daily.
The recommended duration of treatment is 10 days.
Before use, 10 mg of the drug is diluted in 150-200 ml of 0.9% sodium chloride solution, the recommended rate of administration is 40-60 drops / min.

SIDE EFFECT

Perhaps the development of headaches, dizziness, general weakness, which are of a short-term nature and are self-sufficient.

Allergic reactions are possible.

According to the results of clinical studies, a single case of paroxysmal atrial fibrillation was recorded (there was no connection with the drug intake).

CONTRAINDICATIONS

- Pregnancy;

- lactation period;

- age up to 18 years;

- Hypersensitivity to the components of the drug,

PREGNANCY AND LACTATION

Contraindicated in pregnancy and lactation.

APPLICATION FOR CHILDREN

Contraindicated at the age of 18 years.

OVERDOSE

If the daily dose is exceeded, there may be a sedative effect and increased drowsiness.
As an emergency, caffeine sodium benzoate (caffeine) 20% solution in ampoules of 1 ml 2-3 times / day p / k is used.
DRUG INTERACTION

Neurophazole can be used in conjunction with acetylsalicylic acid, enalapril, indapamide, atenolol, nifedipine, digoxin, rheopolyglucin dextran.

Does not affect the narcotic effect of ethanol and the hypnotic effect of thiopental.

Potentiates the anticonvulsant effect of carbamazepine.

It causes an increase in the anxiolytic effect of diazepam.

TERMS OF RELEASE FROM PHARMACY

The drug is released by prescription.

TERMS AND CONDITIONS OF STORAGE

Store in a dark place at a temperature of 0 ° to 25 ° C.
Do not freeze. Keep out of the reach of children. Shelf life - 2 years. Do not use after the time specified on the package.
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