Universal reference book for medicines

Active substance: pyridoxine, thiamine

Type: Complex of B vitamins

Manufacturer: WOERWAG PHARMA (Germany) manufactured by SOLUPHARM PHARMAZEUTISCHE ERZEUGNISSE (Germany)
Composition, form of production and packaging
The solution for intravenous and / or injection is
transparent, with a slight yellowish-green hue.

1 ml

thiamine hydrochloride (Vit B 1 ) 100 mg

pyridoxine hydrochloride (Vit B 6 ) 50 mg

Excipients: tartaric acid - 1.6 mg, water d / and - up to 1 ml.

1 ml - ampoules of dark glass (5) - packings of cellular contour (1) - packs cardboard.


Description of the drug approved by the manufacturer for the printed edition of 2010.


Neurotropic B vitamins have a beneficial effect on inflammatory and degenerative diseases of the nerves and motor apparatus.
Promotes increased blood flow and improves the functioning of the nervous system.
Thiamine plays a key role in the metabolism of carbohydrates, as well as in the Krebs cycle with subsequent participation in the synthesis of TPI (thiamin pyrophosphate) and ATP (adenosine triphosphate).

Pyridoxine is involved in protein metabolism, and in part, in the metabolism of carbohydrates and fats.

The physiological function of both vitamins is the potentiation of each other's action, manifested in a positive effect on the nervous, neuromuscular and cardiovascular systems.
With a deficiency of vitamin B 6 , widespread deficit conditions quickly stop after the administration of these vitamins.

After intramuscular administration, thiamine is rapidly absorbed from the injection site and enters the blood (484 ng / ml after 15 minutes on the first day of dosing at 50 mg) and is distributed unevenly in the body with a content of 15% in leukocytes, 75% in erythrocytes and in plasma 10 %.
In connection with the lack of a significant supply of vitamin in the body, it must enter the body daily. Thiamine penetrates through the blood-brain and placental barriers and is found in breast milk.Thiamine is excreted in the urine in the alpha phase after 0.15 h, in the beta phase - after 1 h and in the terminal phase - for 2 days. The main metabolites are: thiaminic acid, pyramine and some unknown metabolites. Of all the vitamins, thiamine is retained in the body in the least amount. The adult body contains about 30 mg of thiamine in the form of 80% thiamine pyrophosphate, 10% thiamine triphosphate and the rest in the form of thiamine monophosphate.
After intramuscular injection, pyridoxine is quickly absorbed into the bloodstream and distributed in the body, performing the role of coenzyme after phosphorylation of the CH 2 OH group in the 5th position.
About 80% of the vitamin binds to blood plasma proteins. Pyridoxine is distributed throughout the body and crosses the placenta and is found in breast milk, deposited in the liver and oxidized to 4-pyridoxic acid, which is excreted in the urine, maximum 2-5 hours after absorption. The human body contains 40-150 mg of vitamin B6 and its daily elimination rate is about 1.7-3.6 mg and at a rate of replenishment of 2.2-2.4%.

As an aid in the complex treatment of diseases of the nervous system of various origins:

- neuropathy;

- neuralgia;

- including retrobulbar neuritis;

- ganglionitis;

- Herpes zoster;

- paresis of the facial nerve;

- Plexopathy, including solarium;

- polyneuropathy: diabetic, alcoholic, etc.

Neurological manifestations of osteochondrosis:

- myalgia;

- radiculopathy;

- sciatica;

- Lumbago;

- Muscular nocturnal cramps, especially in the elderly.


Intravenous or intramuscular, with pronounced manifestations of 1-2 ml daily 5-7 days, then 1-2 ml 2-3 times a week for 2 weeks, in mild cases 1-2 ml 2-3 times a week 7 -10 days.


Allergic reactions.

In some cases, sweating, tachycardia, acne may occur.

Described skin reactions in the form of itching, urticaria;
shortness of breath, Quincke's edema, anaphylactic shock.

Decompensated heart failure;

- childhood;

- increased individual sensitivity to the components of the drug.


Apply not recommended during pregnancy and lactation.


Contraindicated in childhood.


In cases of very rapid administration of the drug may occur dizziness, arrhythmia, convulsions, they can also be the result of an overdose.
Treatment of an overdose is symptomatic.

Thiamin is completely destroyed in solutions containing sulfites.
Other vitamins are inactivated in the presence of the products of decomposition of vitamin B. Levodopa reduces the effect of therapeutic doses of vitamin B 6 . There may also be interaction with cycloserine, D-penicillamine, epinephrine, norepinephrine, sulfonamides, which reduces the effect of pyridoxine. Thiamine is incompatible with oxidizing substances and substances, mercuric chloride, iodide, carbonate, acetate, tannic acid, iron-ammonium citrate, as well as phenobarbital, riboflavin, benzyl-penicillin, dextrose and metabisulphite. Copper accelerates the destruction of thiamine; In addition, thiamine loses its effect when pH values ​​increase (more than pH 3).

On prescription.


At a temperature of no higher than 25 ° C.
Keep out of the reach of children. Shelf life - 2 years.
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