Universal reference book for medicines
Product name: SODIUM CHLORID (SODIUM CHLORID)

Active substance: sodium chloride

Type: Preparation for rehydration and detoxification for parenteral use

Manufacturer: BAXTER (Spain) manufactured by BIEFFE MEDITAL (Spain)
Composition, form of production and packaging
Solution for infusions 0.9%
transparent, colorless.

1 l

sodium chloride 9 g

Auxiliary substances: water d / and - up to 1 liter.

100 ml - Viaflo containers (50) - cardboard boxes.

Solution for infusions 0.9% transparent, colorless.

1 l

sodium chloride 9 g

Auxiliary substances: water d / and - up to 1 liter.

250 ml - Viaflo containers (30) - cardboard boxes.

500 ml - Viaflo containers (20) - cardboard boxes.

1 liter - Viaflo containers (10) - carton boxes.

Solution for infusions 0.9% transparent, colorless.

1 l

sodium chloride 9 g

Auxiliary substances: water d / and - up to 1 liter.

50 ml - Viaflo containers (50) - cardboard boxes.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2011.

PHARMACHOLOGIC EFFECT

Has a detoxifying and rehydrating effect.
Replenishes sodium deficiency in various pathological conditions of the body and temporarily increases the volume of fluid circulating in the vessels.
Pharmacodynamic properties of the solution are due to the presence of sodium ions and chloride ions.
A number of ions, including sodium ions, penetrate the cell membrane through various transport mechanisms, among which the sodium potassium pump (Na-K-ATPase) is of great importance. Sodium plays an important role in signaling in neurons, electrophysiological processes of the heart, as well as in metabolic processes in the kidneys.
Sodium is excreted mainly by the kidneys, however, while a large amount of sodium undergoes reabsorption (renal reabsorption).
A small amount of sodium is excreted with feces and with sweating.
INDICATIONS

isotonic extracellular dehydration;

- hyponatremia;

- dilution and dissolution of parenterally administered drugs (as a base solution).

DOSING MODE

Intravenously (usually drip).
The required dose can be calculated in mEqV or mmol sodium, the mass of sodium ions or the mass of sodium chloride (1 g NaCl = 394 mg, 17.1 mEq or 17.1 mmol Na and Cl).
The dose is determined depending on the patient's condition, body fluid loss, Na + and Cl-, age, body weight of the patient.
Serum concentrations of electrolytes in plasma and urine should be carefully monitored.
The dose of sodium chloride solution for adults ranges from 500 ml to 3 liters per day.

The dose of sodium chloride solution for children is from 20 ml to 100 ml per day per kg of body weight (depending on age and total body weight).
The rate of administration depends on the patient's condition.
The recommended dose when used for dilution and dissolution of parenterally administered drugs (as a solvent base solution) is in the range of 50 ml to 250 ml per dose of the drug administered.
In this case, the dose and rate of administration of the solution are determined by the recommendations for the administration of the drug administered.
SIDE EFFECT

Acidosis, hyperhydration, hypokalemia.

If used correctly, undesirable effects are unlikely.

When applying sodium chloride solution of 0.9% as a base solution (solvent) for other drugs, the probability of side effects is determined by the properties of these drugs.
In this case, if side effects occur, you should suspend the solution, assess the patient's condition, take adequate measures and save the remaining solution for analysis, if necessary.
If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, tell your doctor.

CONTRAINDICATIONS

- Hypernatremia, acidosis, hyperchloremia, hypokalemia, extracellular hyperhydration;

- circulatory disorders that threaten edema of the brain and lungs;

- edema of the brain, pulmonary edema, acute left ventricular failure, concomitant use of GCS in large doses.

When adding other drugs to the solution, it is necessary to take into account contraindications to these drugs.

With caution: decompensated chronic heart failure, arterial hypertension, peripheral edema, preeclampsia, chronic renal failure (oligo-, anuria), aldosteronism and other conditions associated with sodium retention in the body.

PREGNANCY AND LACTATION

The solution can be administered during pregnancy and lactation.

APPLICATION FOR FUNCTIONS OF THE LIVER

With pointedness: chronic renal failure (oligo-, anuria).

APPLICATION FOR CHILDREN

In the body of children, because of the immaturity of kidney function, sodium excretion can be slowed down.
Therefore, in such patients, repeated infusions should be performed only after determining the concentration of sodium in the plasma.
SPECIAL INSTRUCTIONS

When carrying out any infusion, it is necessary to observe the patient's condition, clinical and biological indicators, it is especially important to evaluate plasma electrolytes.
In the body of children, because of the immaturity of kidney function, sodium excretion can be slowed down. Therefore, in such patients, repeated infusions should be performed only after determining the concentration of sodium in the plasma.
Apply only a clear solution, without visible inclusions, if the package is not damaged.
Enter directly after connecting to the infusion system. Do not use a series connection of plastic containers. This can lead to air embolism due to sucking in the air left in the first container, which can occur before the solution from the next container arrives. The solution should be administered with the use of sterile equipment with compliance with the rules of aseptic and antiseptic. To avoid ingress of air into the infusion system, it should be filled with a solution, releasing the residual air from the container completely. Adding other drugs to the solution can be done before or during the infusion by injection into a specially designed container for this purpose.
As with all parenteral solutions, the compatibility of the added substances with the solution should be determined before dissolution.

Do not apply with a solution of 0.9% sodium chloride preparations known to be incompatible with it.
Determine the compatibility of added drugs with a 0.9% sodium chloride solution should the doctor check the possible discoloration and / or appearance of sediment, insoluble complexes or crystals.
Before adding it is necessary to determine whether the added substance is soluble and stable in water at the pH level as 0.9% sodium chloride solution.

When adding the drug, it is necessary to determine the isotonicity of the resulting solution before infusion.
Before adding to the solution of the preparations, they must be thoroughly mixed in accordance with the rules of asepsis. Prepared solution should be introduced immediately after preparation, do not store!
Adding other drugs or disrupting the technique of administration can cause fever due to the possible ingestion of pyrogens.
In case of development of undesirable reactions, it is necessary to stop the solution immediately. Prior to the application of the solution, do not remove the container from the external protective polypropylene / polyamide bag into which it is placed, since it maintains the sterility of the preparation.
Instruction on the use of containers Viaflo (Vaflo)

1. Opening the package.

a.
Remove the Vioflo container from the outer bag immediately before use.
b.
When tightening the container, it is necessary to check it for its integrity. If mechanical damage is found, the container should be disposed of, as sterility may be impaired.
at.
Check the solution for transparency and no inclusions. The container should be disposed of if transparency is violated or inclusions are present.
2. Preparation for use.

Use sterile materials to prepare and inject the solution, a.
Hang the container by the loop to the tripod. Remove the plastic fuse from the output port located at the bottom of the container:
- grasp one hand for a small wing on the neck of the outlet port,

- grasp the other hand by the large wing on the lid and twist,

- the lid will open.

at.
When staging the infusion system should adhere to the rules of antiseptics.
d. Install the infusion system in accordance with the instructions for the connection, filling the system and introducing the solution, which are contained in the instructions to the system.

3. Adding other drugs to the solution.

Attention: added medications may be incompatible with the solution.

To add before the introduction:

a.
Disinfect the area for injecting drugs on the container (port for drug administration).
b.
Using a syringe with a needle of size 19-22 (1.10-0.70 mm), make a puncture in this area and enter the drug.
at.
Mix the preparation thoroughly with the solution. For high-density preparations, such as potassium chloride, carefully insert the drug through the syringe, holding the container so that the injection port is on top (upside down), then mix.
Caution: do not store containers in which preparations have been added.

To add the drug during the administration:

a.
Move the system clamp that regulates the supply of the solution to the "Closed" position.
b.
Disinfect the area for injecting drugs on the container (port for drug administration).
at.
Using a syringe with a needle of size 19-22 (1.10-0.70 mm), make a puncture in this area and enter the drug.
Remove the container from the tripod and / or turn it upside down.

etc. Remove air from both ports.

e. Thoroughly mix the preparation with the solution.

f.
Return the container to its working position, move the system clamp to the "Open" position and continue the introduction.
Dispose of the containers after a single use.
Dispose of each unused dose.
Do not reconnect partially used containers (regardless of the amount of solution left in it).

Impact on the ability to drive vehicles and manage mechanisms

Not described.

OVERDOSE

Symptoms: nausea, vomiting, diarrhea, spastic abdominal pain, thirst, low saliva and tear, sweating, fever, tachycardia, increased blood pressure, renal failure, peripheral edema, pulmonary edema, respiratory arrest, headache, dizziness, anxiety, irritability, weakness, muscle cramps and stiffness, generalized convulsions, coma and death.
Excessive administration of the solution can cause hypernatremia.
Excessive intake of chloride into the body can lead to hyperchloremic acidosis.

When used as a base solution for dilution and dissolution of other drugs, symptoms and complaints with excessive administration are most often associated with the properties of the drugs administered.

In case of unintended excess solution administration, treatment should be discontinued and the patient's condition assessed.

Treatment: symptomatic.

DRUG INTERACTION

Not described.

When mixed with other drugs, you need to visually check for compatibility.
To do this, you should observe the resulting solution to change its color and / or precipitate, the appearance of crystals, insoluble complexes. It is also necessary to take into account the instructions for the use of added drugs.
TERMS OF RELEASE FROM PHARMACY

On prescription.

TERMS AND CONDITIONS OF STORAGE

At a temperature of no higher than 25 ° C.
Keep out of the reach of children. Shelf life: 50 ml - 18 months; 100 ml - 2 years; 250,500 and 1000 ml - 3 years.
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