Universal reference book for medicines
Product name: NALTREXONE FV (NALTREXONE FV)

Active substance: naltrexone

Type: Competitive opioid receptor antagonist

Producer: MOSCOW PHARMACEUTICAL FACTORY (Russia)
Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

PHARMACHOLOGIC EFFECT
Competitive opioid receptor antagonist.
Eliminates the central and peripheral effects of opioids, including endogenous endorphins. Acts more intensively and more durable than naloxone.
PHARMACOKINETICS
After ingestion, naltrexone is almost completely absorbed from the digestive tract.
C max naltrexone and its active metabolite 6 -? - naltrexol in blood plasma is achieved after 1 hour.
With prolonged use, naltrexone does not accumulate in the body, while the concentration of 6 -? - naltrexol in plasma reaches 40%.
This is due to the fact that T 1/2 of the metabolite is greater than that of naltrexone.
95% of the dose of naltrexone is biotransformed in the liver into pharmacologically active metabolites, the main of which is 6 -? - naltrexol is also an antagonist of opioids.
The second metabolite is 2-hydroxy-3-methoxy-6 -? - naltrexol. Naltrexone and its metabolites undergo intrahepatic recirculation.
Naltrexone and its metabolites are excreted mainly by the kidneys.
The amount of free naltrexone that is excreted in the urine is less than 1%, and the amount of free and bound 6 -? - naltrexol is approximately 38%. The average T 1/2 of naltrexone is 4 hours, 6 -? - naltrexol - 13 hours.
INDICATIONS
As an adjuvant for abstinence after the withdrawal of opioid analgesics.

DOSING MODE
Is taken internally.
Single dose is 25-50 mg. The scheme and duration of treatment are set individually.
SIDE EFFECT
From the side of the central nervous system: agitation, a state of prostration, irritability, dizziness;
rarely - depression, paranoia, fatigue, confusion, disorientation in time and space, hallucinations, nightmares, drowsiness, decreased visual acuity, pain and burning sensation in the eyes, photophobia, pain and a feeling of stuffiness in the ears, tinnitus.
From the digestive system: decreased appetite, diarrhea, constipation;
rarely - dry mouth, flatulence, aggravation of hemorrhoid symptoms, erosive and ulcerative lesions of the gastrointestinal tract, increased activity of hepatic transaminases.
On the part of the urinary system: rarely - frequent or violated urination.

On the part of the reproductive system: delayed ejaculation, reduction of sexual potency;
rarely - increased or decreased libido.
Dermatological reactions: rash;
rarely - increased secretion of sebaceous glands, epidermophytia stop, skin changes, corresponding to the first stage of frostbite.
On the part of the respiratory system: rarely - hyperemia of the vessels of the nasal cavity, nosebleeds, rhinorrhea, sneezing, dryness in the throat, increased mucus, sinusitis, shortness of breath, tracheophone, cough, shortness of breath.

From the cardiovascular system: rarely - phlebitis, swelling, increased blood pressure, nonspecific changes in the cardiogram, tachycardia, a feeling of heat in the limbs, a sudden sensation of blood flow to the face.

Other: chills feel possible;
rarely - increase or loss of appetite, weight gain, pathological yawning, fever, pain in the groin, lymphadenopathy, lymphocytosis; describes one case of idiopathic thrombocytopenic purpura in a patient who appears to have been sensitized to naltrexone during the previous treatment.
CONTRAINDICATIONS
Acute hepatitis, hepatic insufficiency.

PREGNANCY AND LACTATION
The safety of naltrexone during pregnancy and lactation is not established.

APPLICATION FOR FUNCTIONS OF THE LIVER
Use with caution in patients with impaired renal function.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
Contraindicated in acute hepatitis, liver failure.

SPECIAL INSTRUCTIONS
Naltrexone can be used only in cases where the patient does not take opioid analgesics for at least 7-10 days.

Naltrexone can be effective in the treatment of chronic alcoholism.

Use with caution in patients with impaired liver and / or kidney function.
During the treatment period, regular monitoring of liver function is recommended.
Naltrexone should be discontinued at least 48 hours before surgery, requiring the use of opioid analgesics.

It should be borne in mind that with the use of naltrexone the probability of complete recovery from opioid dependence is variable.

DRUG INTERACTION
With simultaneous use with naltrexone, the effectiveness of opioid receptor agonists (antitussives, analgesics) decreases.

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