Universal reference book for medicines
Product name: NALORIUS (NALORIUS)

Active substance: desloratadine

Type: The blocker of histamine H 1 -receptors.
Anti-allergic drug
Manufacturer: NANOLEK (Russia)
Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

PHARMACHOLOGIC EFFECT
The blocker of histamine H 1 -receptors (long-acting).
It is the primary active metabolite of loratadine. Inhibits the release of histamine and leukotriene C 4 from mast cells. Prevents development and facilitates the course of allergic reactions. It has anti-allergic, antipruritic and antiexcudative action. Reduces the permeability of capillaries, prevents the development of edema of tissues, relieves spasm of smooth muscles. Virtually does not have a sedative effect and when taken in a dose of 7.5 mg does not affect the rate of psychomotor reactions. In comparative studies of desloratadine and loratadine, no qualitative or quantitative differences in the toxicity of the two drugs in comparable doses (taking into account the concentration of desloratadine) have not been revealed.
PHARMACOKINETICS
After oral administration, it begins to be detected in plasma after 30 minutes.
Food does not affect distribution. Bioavailability is proportional to the dose in the range of 5 mg to 20 mg. Binding to plasma proteins is 83-87%. After a single dose of 5 mg or 7.5 mg of C max is achieved after 2-6 hours (an average of 3 hours). Does not penetrate the BBB. Intensively metabolized in the liver by hydroxylation to form 3-OH-desloratadine, combined with glucuronide, only a small part of the ingested dose is excreted by the kidneys (<2%) and with feces (<7%). T 1/2 - 20-30 hours (on the average - 27 hours). With the use of desloratadine in a dose of 5 mg to 20 mg 1 time / day for 14 days, no signs of clinically significant cumulation were detected.
INDICATIONS
Seasonal allergic rhinitis, chronic idiopathic urticaria.

DOSING MODE
Adults and adolescents aged 12 years and older are prescribed inside, regardless of food intake, at a dose of 5 mg / day.

Children aged 1 to 5 years - 1.25 mg 1 time / day, at the age of 6 to 11 years - 2.5 mg 1 time / day.

SIDE EFFECT
From the side of the nervous system: headache, hallucinations, psychomotor hyperreactivity, convulsions.

From the digestive system: dry mouth, hepatitis.

Other: photosensitization, myalgia, dyspnea, feeling tired.

CONTRAINDICATIONS
Phenylketonuria, pregnancy, lactation, children under 1 year, hypersensitivity to desloratadine.

PREGNANCY AND LACTATION
Desloratadine is contraindicated in pregnancy and lactation (breastfeeding).

APPLICATION FOR FUNCTIONS OF THE LIVER
With caution appoint desloratadine in severe renal failure.

APPLICATION FOR CHILDREN
Contraindicated in children under 2 years.

SPECIAL INSTRUCTIONS
With caution appoint desloratadine in severe renal failure.

Impact on the ability to drive vehicles and manage mechanisms

There was no adverse effect on driving or complicated technical devices.

DRUG INTERACTION
The study of interaction with ketoconazole and erythromycin showed no clinically significant changes.

Does not affect the effects of ethanol.

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