Universal reference book for medicines
Name of the drug: NAZOL ® ADVANCE (NAZOL ADVANCE)

Active substance: oxymetazoline

Type: Vasoconstrictive drug for topical application in ENT practice

Manufacturer: BAYER (Russia) manufactured by ISTITUTO de ANGELI (Italy)
Composition, form of production and packaging
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Spray nasal 0.05% in the form of a clear, colorless solution with a weak smell of menthol and camphor.
1 ml

hydroxymetazoline hydrochloride 500 μg

Excipients: benzalkonium chloride (50% solution), camphor, eucalyptol, menthol, benzyl alcohol, disodium edetate, polysorbate 80, propylene glycol, sodium hydrogen phosphate, sodium dihydrogen phosphate, purified water.

15 ml - bottles of low density polyethylene (1) with a spray - packs cardboard.

30 ml - bottles of low-density polyethylene (1) with a sprayer - packs of cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2013.

PHARMACHOLOGIC EFFECT

Vasoconstrictive drug for topical application in ENT practice.

Oksimetazolin belongs to the group of alpha-adrenomimetics for topical application.
Has vasoconstrictive effect. With intranasal administration reduces edema of the mucous membrane of the upper respiratory tract, which leads to the relief of nasal breathing and the opening of the mouths of the adnexal sinuses and Eustachian tubes. The effect of the drug manifests itself 10-15 minutes after application and lasts for 10-12 hours.
PHARMACOKINETICS

Data on the pharmacokinetics of Nasol Advance is not available.

INDICATIONS

- to facilitate nasal breathing for colds and viral infections of the upper respiratory tract, sinusitis, rhinitis of any etiology.

DOSING MODE

Adults and children over 12 years of age are prescribed 2-3 injections in each nasal passage 2 times / day, children aged 6 to 12 years (under supervision of adults) - 1 injection in each nasal passage 2 times / day.
Do not use the drug more than 2 times / day.
It is not recommended to use the drug for more than 3 days.
With frequent or prolonged use of the drug, a feeling of difficulty in nasal breathing may reappear or worsen. If these symptoms appear, discontinue treatment and consult a doctor.
When injecting, do not toss the head back and do not spray in the prone position.

SIDE EFFECT

Local reactions: sometimes a burning sensation or dryness of the nasal membranes, dryness in the oral cavity and pharynx, sneezing, an increase in the secretion secreted from the nose.
In rare cases, after the effect of using the drug has passed, a strong sense of "stuffiness" of the nose (reactive hyperemia).
Systemic reactions: increased blood pressure, headache, dizziness, palpitation, increased anxiety, nausea, insomnia.
With prolonged use of the drug (more than 7 days), reactive hyperemia of the nasal mucosa, atrophy of the nasal mucosa are possible.
CONTRAINDICATIONS

- Atrophic rhinitis;

- children's age till 6 years;

- Pregnancy;

- lactation period;

- Hypersensitivity to the components of the drug.

With caution should be used in patients with cardiovascular diseases (arterial hypertension, ischemic heart disease, chronic heart failure, tachycardia, arrhythmias), a violation of carbohydrate metabolism (diabetes mellitus), thyroid dysfunction (hyperthyroidism), pheochromocytoma, prostatic hyperplasia with clinical symptoms, chronic renal failure, zakratougolnoy glaucoma, with the simultaneous use of MAO inhibitors, tricyclic antidepressants.

PREGNANCY AND LACTATION

The drug is contraindicated in pregnancy and during breastfeeding.

APPLICATION FOR FUNCTIONS OF THE LIVER

With caution should prescribe the drug for chronic kidney failure.

APPLICATION FOR CHILDREN

Contraindicated: children under 6 years.
Children aged 6 to 12 years (under the supervision of adults) - 1 injection in each nasal passage 2 times / day.
SPECIAL INSTRUCTIONS

It is not recommended to apply Nazol Advance for more than 3 days.

Avoid contact with the eyes.
The drug has an effect on vision, possibly reducing the reaction rate.
To avoid the spread of infection, it is necessary to use the drug individually.

OVERDOSE

Symptoms: prolonged or frequent use of the drug in the nasal cavity can cause nausea, increased blood pressure, tachycardia, CNS depression.

Treatment: conduct symptomatic therapy.

DRUG INTERACTION

When used simultaneously with MAO inhibitors and tricyclic antidepressants, there may be an increase in blood pressure.

The drug slows the absorption of local anesthetic drugs, lengthens their effect.

Co-administration of other vasoconstrictor drugs increases the risk of side effects.

TERMS OF RELEASE FROM PHARMACY

The drug is approved for use as a means of OTC.

TERMS AND CONDITIONS OF STORAGE

The drug should be stored in a dry, inaccessible to children, at a temperature of 2 ° to 25 ° C.
Shelf life - 2 years.
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