Universal reference book for medicines
Product name: MAGVIT (MAGVIT)

Active substance: magnesium citrate, pyridoxine

Type: Magnesium-containing drug

Manufacturer: MINSKINTERKAPS UP (Republic of Belarus)
Composition, form of production and packaging
?
Capsules hard gelatinous, size №0, yellow; the contents of the capsules are white or white powder with a light yellowish or grayish hue of color.
1 caps.

magnesium citrate 350 mg,

which corresponds to a magnesium content of 50 mg

pyridoxine hydrochloride 5 mg

Auxiliary substances: potato starch 45.2 mg, magnesium stearate 2.5 mg, lactose (sufficient amount to obtain a capsule content of 500 mg).

Composition of gelatin capsule shell: gelatin pharmaceutical capsule 80.736 mg, glycerol 0.125 mg, purified water 13.92 mg, methylparahydroxybenzoate 0.35 mg, propyl parahydroxybenzoate 0.086 mg, sodium lauryl sulfate 0.058 mg, titanium dioxide 0.643 mg, dyes (quinoline yellow E104 0.058 mg, sunset E110 0.0096 mg ).

10 pieces.
- packings cellular planimetric (3) - packs cardboard.
INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2011.

PHARMACHOLOGIC EFFECT

Pharmacological properties of the drug are due to the pharmacological properties of magnesium and pyridoxine hydrochloride.

Magnesium participates in the transfer, storage and utilization of energy, the synthesis of protein and nucleic acids, in a number of mitochondrial processes;
is a cofactor of many enzymatic reactions; controls the balance of intracellular potassium.
Magnesium is an obligatory participant in the synthesis of all neuropeptides in the brain.
It is a part of 13 metalloproteins, more than 300 enzymes, including glutathione synthetase, which converts glutamate into glutamine. Magnesium is involved in the synthesis of nucleic acids and proteins in the nucleus and ribosomes, participates in DNA replication and RNA transcription. Deficiency of magnesium in the body is manifested by muscle weakness, tremor, tetany, ataxia, increased reflex excitability, irritability, sleep disorders, heart rhythm disturbances, and diarrhea. With secondary magnesium deficiency, clinical symptoms are diverse and often have a nonspecific character. Pyridoxine hydrochloride participates as a coenzyme in protein metabolism and synthesis of neurotransmitters, improves lipid metabolism in atherosclerosis. Entering the body, it is phosphorylated, converted to pyridoxal-5-phosphate, is part of the enzymes that perform decarboxylation and reamination of amino acids and facilitates the transport of amino acids through the cell membrane. It plays an important role in the metabolism of tryptophan, glutamic acid, cysteine, methionine. Pyridoxine is necessary for the activation of phosphorylase, for the formation of neurotransmitters, gamma-aminobutyric acid, glycine, serotonin. It is involved in the metabolism of vitamin B 12 , folic acid, in the synthesis of porphyrins, in the exchange of unsaturated fatty acids. The use of a combined preparation containing magnesium and vitamin B 6 is justified for the following reasons:
- vitamin B 6 and magnesium supplement each other's pharmacological action;

- B 6 increases magnesium concentration in plasma and in erythrocytes and reduces the amount of magnesium withdrawn from the body;

- B 6 improves the absorption of magnesium from the digestive tract and its penetration into the cells;

- magnesium activates the process of transformation of pyridoxine into its active metabolite pyridoxal-5-phosphate in the liver;

- B 6 promotes increase and fixation of intracellular magnesium.

PHARMACOKINETICS

The absorption of magnesium in the gastrointestinal tract is 50% of the ingested dose.
In the body, magnesium is distributed mainly in the intracellular space (about 99%). The main way to excrete magnesium is the urinary system. Excretion obeys the circadian rhythm with preferential excretion at night and is regulated by the digestive canal, kidneys and bone tissue. Pyridoxine hydrochloride is absorbed in the small intestine, with blood flow spread to tissues and, penetrating into cells, is phosphorylated with the participation of ATP and pyridoxalkinases. The decomposition of coenzymes is carried out by dephosphorylation and oxidation in tissues. The main product of catabolism is 4-pyridoxic acid, which is excreted in urine.
INDICATIONS

Defined magnesium deficiency, isolated or associated with other conditions.

DOSING MODE

Before taking the drug, you should consult your doctor.

Adults take 2 capsules 2-3 times a day.
The duration of the course of treatment is 1-2 months.
Capsules are taken with food, washed down with a glass of water.

Treatment should be discontinued after the normalization of the magnesium concentration in the blood.

SIDE EFFECT

Allergic reactions to the components of the drug.
Disorders from the gastrointestinal tract (diarrhea, abdominal pain, constipation, nausea, vomiting, flatulence).
CONTRAINDICATIONS

Hypersensitivity to the components of the drug, marked renal failure (creatinine clearance less than 30 ml / min), phenylketonuria, children's age.

Carefully.
With moderate failure of kidney function, as there is a risk of hypermagnesemia.
PREGNANCY AND LACTATION

During pregnancy, the drug can be used only on the advice of a doctor.
Magnesium penetrates into breast milk. Avoid the use of the drug during breastfeeding.
APPLICATION FOR FUNCTIONS OF THE LIVER

Contraindicated in severe renal failure (creatinine clearance less than 30 ml / min).

With caution: moderate failure of kidney function, as there is a risk of hypermagnesemia.

APPLICATION FOR CHILDREN

Contraindicated in childhood.

SPECIAL INSTRUCTIONS

In case of concomitant calcium deficiency, magnesium deficiency should be eliminated before the introduction of additional calcium intake.

With frequent use of laxatives, alcohol, increased physical and mental stress, the need for magnesium increases, which can lead to the development of a deficiency of magnesium in the body.

OVERDOSE

Symptoms of an overdose: a drop in blood pressure, nausea, vomiting, slow reflexes, respiratory depression, coma, cardiac arrest and paralysis of the heart, anuria.

Treatment: rehydration, forced diuresis.
With renal failure, hemodialysis or peritoneal dialysis is necessary.
DRUG INTERACTION

When using other medicines, you should always inform the doctor about it, or consult a doctor or pharmacist about the possibility of using the drug "Magvit".

Simultaneous use of drugs containing phosphates or calcium salts can significantly reduce the absorption of magnesium in the gastrointestinal tract.
Magnesium preparations reduce the absorption of tetracycline, it is recommended to make an interval of 3 hours before using Magvit.
Magnesium weakens the effect of oral thrombolytic agents, reduces the absorption of iron.

TERMS OF RELEASE FROM PHARMACY

The drug is approved for use as a means of OTC.

TERMS AND CONDITIONS OF STORAGE

The drug is stored in a dry, dark place at a temperature of 15 ° C to 25 ° C.
Keep out of the reach of children.
Shelf life - 2 years.
Do not use after the expiry date printed on the package.
Alphabetical index of medicines:
A  B  V  G  D  E  J
Z  I  Y  K  L  M  N
O  P  R  S  T  U  F
H  C  CH  SH  E  U  Y
Rambler's Top100
Privacy policy:
Copyright 2009 - 2017. Universal reference book of medicines. All rights reserved.
When using site materials, an active hyperlink is required!