Universal reference book for medicines
Name of the drug: MARDIL ZINK (MARDIL ZINK)

Active substance: nonappropriate

Type: The drug for topical treatment of benign skin lesions with cauterizing and mummifying effect

Manufacturer: OXYGON (Russia) manufactured CENTRAL EUROPEAN PHARMACEUTICAL COMPANY (Russia)
Composition, form of production and packaging
Topical solution
1 ml

zinc 2-chloropropionate solution 1.5% in 2-chloropropionic acid 0.3 ml

1 ml - bottles of dark glass (1) - containers of foam plastic (1) - packs of cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2010.

PHARMACHOLOGIC EFFECT

Mardyl Zinc ® is a 30% aqueous solution of zinc chloropropionate and 2-chloropropionic acid.
With topical application on the affected areas of the mucous membrane, Mardil Zinc ® is able to interrupt the growth and vital functions of pathologically altered cells and tissues, incl. benign neoplasms of the mucosa, through anti-coagulation, dehydration and devitalization. With topical application to the affected areas of the mucosa, the drug leads to fixation followed by necrotic tissue pathology. The direct effect of the drug is expressed in the discoloration of the mucous membrane with the appearance of a characteristic pale gray shade. When the preparation is applied to the ectopic cylindrical epithelium (cervical ectopia and the transformation zone), they coagulate and devitalize. The intact multilayered flat epithelium of the vaginal part of the cervix and vaginal mucosa, which is more resistant to the effects of Mardil Zinc ® , remains virtually intact. Healing occurs without complications in the absence of secondary infection, does not leave scarring, deformations of adjacent tissues and violations of organs.
PHARMACOKINETICS

When applied to the affected areas of the mucous membrane, Mardil Zinc ® is not absorbed and has no systemic effect on the body.

INDICATIONS

For topical treatment of benign formations of the mucous membranes of the vagina and cervix:

anogenital warts;

ectopia of the cervix.

DOSING MODE

Treatment of ectopy

Before the procedure is mandatory oncocytological examination of smears-prints.
The procedure should be performed by a specialist gynecologist or dermatovenereologist using a colposcope. The drug should be applied only to the altered tissue, avoiding the solution on a healthy mucous membrane. Before the treatment procedure it is necessary to prepare the vagina and cervix by removing the vaginal slime with a cotton swab. The application is carried out once by a universal probe or an applicator. The effect is manifested as the appearance of a whitish-yellow color of the tissue. In the following, a decrease in the scab and its rejection is noted. The duration of epithelialization depends on the size of the ectopia and can range from 2 to 6 weeks. The amount of the drug applied depends on the area of ​​the lesion and can vary from 0.02 to 0.2 ml.
The maximum daily dose should not exceed 0.2 ml.

Treatment of anogenital warts

Treatment is carried out on an outpatient basis under the supervision of a physician.
The procedure does not require anesthesia. The drug is applied with a probe a universal or an applicator. After applying the drug, the color of the tissues changes to a whitish-gray color. The number of applications and the volume of the drug applied depend on the size of the formation and the area of ​​the lesion of the mucous membrane and can be 0.02 ml-0.2 ml.
The maximum daily dose should not exceed 0.2 ml.

In the presence of extensive lesions, treatment with the drug should be carried out in several stages with an interval of at least 24 hours. During each procedure, no more than 2-3 lesions with a total area of ​​up to 3 cm 2 can be treated.

When applying the drug Mardil Zinc there is a small swelling of the mucous membrane.
Within 2-3 days after using the drug, necrotic tissues are rejected.
Complete regeneration is observed during 10-14 days.

With large anogenital warts in case of incomplete necrosis, it is possible to apply the drug again after 5-7 days.

SIDE EFFECT

Possible short-term itching and burning, swelling of the tissue.

Allergic reactions with individual sensitivity to the components of the drug.

CONTRAINDICATIONS

- malignant neoplasms of the cervix, vagina and anogenital zones;

- Cervical intraepithelial neoplasia (CIN);

- Pregnancy;

- lactation period;

- children's age till 18 years;

- Hypersensitivity to the components of the drug.

PREGNANCY AND LACTATION

Contraindicated in pregnancy and lactation.

APPLICATION FOR CHILDREN

Contraindicated in patients under the age of 18 years.

SPECIAL INSTRUCTIONS

Handle with care.
Before opening the vial should be shaken and move the solution, which got in the top of the bottle, to its bottom.
The opened vial should be in a strictly vertical position.

Mardil Zinc ® contains an acid in its composition.
Avoid getting the product on healthy skin or mucous membranes. If you accidentally get the drug Mardil Zinc ® on a healthy skin or mucous, it is necessary to remove the drug as quickly as possible with a dampened
water wadded tampon.

If accidental ingestion occurs in the eyes, rinse immediately with plenty of water and 1%

sodium bicarbonate solution, and then consult a doctor.

After carrying out medical manipulations, it is possible to conduct hygienic procedures.
However, you should avoid visiting the pool, baths, saunas, swimming in open water, taking baths.
Before discarding the vial, the remainder of the drug should be rinsed in running water.
Empty vial can be thrown into the garbage container.
OVERDOSE

If the product is used incorrectly, erosion can occur.
To prevent acid burns, the preparation should be rinsed with running water. Healing can occur independently without the use of additional drugs or with the use of wound healing drugs.
DRUG INTERACTION

The interaction of Mardil Zinc ® with other topical drugs has not been established.

TERMS OF RELEASE FROM PHARMACY

The drug is released by prescription.

TERMS AND CONDITIONS OF STORAGE

Store in a dark place at a temperature of no higher than 25 ° C.
Keep out of the reach of children. Shelf life - 3 years. Do not use the medicinal product after the expiration date indicated on the package.
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