Universal reference book for medicines

Active substance: hexetidine

Type: Antiseptic for topical application in ENT practice and dentistry

Manufacturer: Otisifarm (Russia) manufactured by FARMSTANDART-Lekssredstva (Russia)
Composition, form of production and packaging
Spray for topical application in the form of an almost colorless liquid with a characteristic smell of menthol.
100 ml

hexiethidine 200 mg

Auxiliary substances: sodium saccharinate dihydrate - 40 mg, citric acid monohydrate - 70 mg, sodium hydroxide (sodium hydroxide) - 19 mg, glycerol (glycerin) - 17000 mg, ethanol (rectified ethyl alcohol) - 4000 mg, lauromacrogol (macrogol lauryl ether ) - 1500 mg, cineole (eucalyptol) - 20 mg, levomentol (L-menthol) - 20 mg, peppermint leaves oil - 10 mg, purified water - up to 100 ml.

40 ml - aluminum cylinders (1) with a metering pump and a nebulizer for oral use - packs cardboard.


Description of the drug approved by the manufacturer for the printed edition of 2016.


Antiseptic preparation for topical application.
Has antimicrobial, antifungal, analgesic, enveloping and deodorizing action.
The antimicrobial effect of Maxocold®
Lor is associated with the suppression of oxidative reactions of the metabolism of bacteria (hexethidine-thiamine antagonist).The drug has a wide range of antibacterial and antifungal effects, in particular against Gram-positive bacteria and fungi of the genus Candida, however, the Maxi-Cold ® Lor may also have an effect in the treatment of infections caused, for example, by Pseudomonas aeruginosa or Proteus spp. At a concentration of 100 mg / ml, the drug suppresses most strains of bacteria. The development of stability was not observed. Maxycold ® Lor has a weak anesthetic effect on the mucosa.

After a single application, the local action of hexacetin proceeds 10-12 hours.

The drug is almost not absorbed from the surface of the mucous membranes and does not have a systemic effect.
After a single application of the active substance, its traces are found on the gingival mucosa for 65 hours. In the dental plaques, active concentrations are maintained for 10-14 hours after application.

- Infectious and inflammatory diseases of the oral cavity and throat (tonsillitis, including Plaut-Vincent's angina, pharyngitis, stomatitis, aphthous ulcers of the oral cavity, glossitis, periodontitis, gingivitis, periodontitis, periodontitis, alveolitis), gum bleeding;

- with ARI - as an auxiliary, as part of complex therapy;

- fungal infections of the oral cavity, pharynx and larynx (thrush);

- injuries and surgical interventions in the oral cavity, pharynx and larynx (both before and after their holding), incl.
prevention of infection of the alveoli after extraction of the tooth;
- as a means of oral hygiene to eliminate unpleasant odor (deodorizing effect);

- prevention of superinfections in decaying tumors of the oral cavity and larynx.


Apply topically, after a meal or in between meals.

With the help of spray treated affected areas in the mouth and throat.
Frequency of application for adults and children over 3 years - 2-3 times / day. If necessary, more frequent use of the drug. The course of treatment is 5-7 days. For proper use of the drug, you must perform the following actions:
1. Remove the lid from the cylinder, install the nebulizer in the corresponding opening of the top of the cylinder.

2. At first use, several short presses on the spray gun (in order to ensure a uniform spraying of the contents of the balloon) must be made beforehand.

3. Enter the required amount of the drug in the oral cavity by pressing the sprayer 3-4 times until it stops.
During the introduction of the drug should hold your breath.
4. After use, remove the nebulizer, rinse it in running water and dry it at room temperature in a place inaccessible to children.

5. Store the nebulizer in the package with the product.

During the introduction, the balloon should be kept upright.


Local reactions: allergic reactions, burning of the mucous membrane of the mouth.

In case of accidental ingestion: nausea.

With prolonged use: a violation of taste.


- Atrophic pharyngitis;

- children's age till 3 years;

- Hypersensitivity to the components of the drug.


There is no information about any adverse effects of hexaetidine in pregnancy and lactation.
Before prescribing the drug to pregnant or lactating women, the physician should carefully weigh the benefits of treatment for the mother and the possible risk to the fetus and the baby, given the lack of sufficient data on the penetration of the drug through the placenta and into breast milk.

Contraindicated in children under 3 years.
Children can use the drug from such an age when they do not resist the foreign object (spray) in the mouth when applying the spray and are able to hold their breath when injecting the drug.

Children can use the drug from such an age when they do not resist the foreign object (spray) in the mouth when applying the spray and are able to hold their breath when injecting the drug.

The spray should not be inhaled;
Avoid contact with the eye.
After applying the spray, the applicator should be rinsed with warm water.

It should be borne in mind that the spray contains ethanol - 24-48 mg in a daily dose.

It should be taken into account that the cylinder is under pressure.
Do not burn, puncture or open the bottle, even if it is empty.
Impact on the ability to drive vehicles and manage mechanisms

In the absence of a general reaction to taking the drug, the performance of potentially hazardous activities requiring special attention and quick reactions (including driving) is not contraindicated.


Hexetidine in this dosage is not toxic.
The ingestion of large amounts of the drug leads to vomiting, so no significant absorption is expected.
Cases of ethanol poisoning in case of an overdose have not been described.
Acute alcohol poisoning is very unlikely, but it is theoretically possible if a large dose of the drug is ingested by a small child.
In all cases of overdose, immediately consult a physician.

Treatment is symptomatic: reception of enterosorbents (activated carbon), gastric lavage, abundant drinking.
Gastric lavage is necessary within 2 hours after swallowing an excessive dose.

There are no data on the drug interaction of the Maxxold® Lor drug.


The drug is approved for use as a means of OTC.


The drug should be stored out of reach of children at a temperature of no higher than 25 ° C.
Do not freeze! Shelf life - 2 years.
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