Universal reference book for medicines

Active substance: nifuratel, nystatin

Type: The drug with antibacterial, antiprotozoal and antifungal action for topical application in gynecology

Manufacturer: POLICHEM SrL (Italy) manufactured by DOPPEL FARMACEUTICI (Italy)
Composition, form of production and packaging
The cream is vaginal
liquid, homogeneous, yellow in color.

1 g

nifuratel 100 mg

nystatin 40 thousand IU

Auxiliary substances: xalifin 15 10.0 g, methyl parahydroxybenzoate 0.11 g, propyl parahydroxybenzoate 0.04 g, glycerol (glycerin) 5.0 g, sorbitol 70% solution 10.0 g, propylene glycol 5.0 g, carbomer 0.40 g, triethanolamine 30% 1.50 g, purified water to 100.0 g.

30 g - aluminum tubes (1) complete with an applicator (graduated syringe) - packs cardboard.


Description of the drug approved by the manufacturer for the printed edition of 2016.


Antimicrobial preparation for topical application.
Has antiprotozoal, antifungal and antibacterial action.
Nifuratel - a derivative of nitrofuran - is highly active against a number of bacteria, fungi and protozoa (including Trichomonas vaginalis).

Nystatin is an antifungal antibiotic of the polyene group.
By binding to sterols in the cell membrane of fungi, it breaks its permeability, which leads to cell death.Highly active against Candida albicans.
The combination of nifuratel and nystatin allows to achieve more pronounced antifungal action and significantly expand the spectrum of antimicrobial action.

High efficacy and low toxicity of the components of the drug cause a wide range of its clinical applications in the treatment of mixed etiologies of vaginitis, in particular, the use for the prevention of fungal infections caused by specific treatment of trichomoniasis.

Cream vaginal McMiror The complex does not violate the physiological flora, which allows to avoid the development of dysbiosis and quickly restore the normocenosis of the vagina.


The conducted studies confirm that in vaginal application in animals (rabbits and dogs) with repeated administration of a daily dose, which is 30 times higher than the therapeutic dose, the substances included in the preparation are not absorbed into the bloodstream and do not have a systemic effect.
Studies of the pharmacokinetics of the drug in humans have not been conducted.

- vulvovaginal infections caused by drug-susceptible pathogens: incl.
bacterial vaginitis, vaginal trichomoniasis; Vaginitis caused by fungi of the genus Candida, mixed vaginitis.

Intravaginal: 2.5 g of cream once or twice a day, in the evening or in the morning, as recommended by the doctor, for 8 days.

The required dose of cream should be administered with a graduated applicator.

Instructions for using a graduated applicator

Screw the graduated applicator onto a tube of cream.
Collect the necessary amount of cream (in accordance with the scale lines, indicating the amount in grams), pressing on the tube. Disconnect from the tube, insert into the vagina, squeeze out the contents of the applicator, pressing the rod.
The presence of a special nozzle allows you to enter the cream without damaging the hymen.
To do this, remove the cannula from the top of the stem and screw it onto the syringe head from the opposite side before inserting the cream into the vagina.

Allergic reactions are possible in the form of skin rashes or itching.
With the development of allergic reactions, the drug should be discontinued.

- hypersensitivity to nifuratel, nystatin or any auxiliary substance of the drug.


The use of the drug during pregnancy is possible if the potential benefit to the mother exceeds the risk to the fetus or child.

During the treatment period, it is necessary to resolve the issue of stopping breastfeeding.


It is necessary to conduct simultaneous treatment of the sexual partner because of the danger of re-infection.
During the treatment with the drug, sexual intercourse should be avoided.
Influence on ability to drive vehicles, mechanisms

The use of the drug does not affect the ability to drive vehicles and other activities that require increased attention.


No cases of drug overdose have been reported.


There is no clinically significant interaction of the McMiore Complex cream with other drugs.


The drug is released by prescription.


In the dark place at a temperature of no higher than 25 ° C.
Keep out of the reach of children! Shelf life - 3 years. Do not use after expiry date.
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