Universal reference book for medicines

Active substance: magnesium lactate, pyridoxine

Type: A drug that replenishes magnesium deficiency in the body

Manufacturer: NIZHFARM (Russia) manufactured by STADA-VN JOINT VENTURE (Vietnam)
Composition, form of production and packaging
Tablets, covered with an enteric coating of white color, oval, biconvex.
1 tab.

magnesium lactate dihydrate 470 mg

which corresponds to 48 mg of magnesium

pyridoxine hydrochloride 5 mg

(vitamin B 6 )

Auxiliary substances: wheat starch 40 mg, lactose monohydrate 60 mg, cellulose microcrystalline 25 mg, povidone K90 15 mg, croscarmellose sodium 20 mg, stearic acid 15 mg, magnesium stearate 15 mg.

Ingredients of the enteric coating: methacrylic acid and methyl methacrylate copolymer [1: 1] (eudragit L 100) 22.5 mg, triethyl acetate 4.5 mg, talc 7.5 mg, titanium dioxide 4.583 mg.

10 pieces.
- Cellular outline packaging (aluminum / PVC) (5) - cardboard packs.

Description of the drug approved by the manufacturer for the printed edition of 2013.


Combined drug;
contains therapeutic doses of magnesium lactate and pyridoxine hydrochloride, improving the absorption of magnesium in the intestine, its transport from the blood and interstitial fluid into the cells.
Magnesium is a vital element that ensures the supply of glycolysis products to the Krebs cycle, is involved in the synthesis and decomposition of nucleic acids, the synthesis of proteins, fatty acids and lipids, in particular phospholipids, also participates in the synthesis of enzymes that provide energy responses (glycolysis, hydrolytic cleavage ATP).
Magnesium is necessary for the implementation of neuromuscular transmission, the mineralization of bones, the realization of the effect of parathyroid hormone. Magnesium ions are a physiological antagonist of calcium ions. Magnesium forms sites in the structure of a number of receptors (NMDA-, AMPA receptors for acetylcholine, noradrenaline and dopamine), it is necessary for the normal exchange of neurotransmitters (catecholamines, tyrosine, dopamine, noradrenapine, serotonin, y-aminobutyric acid). Magnesium, through the activation of tyrosine kinase, helps to reduce insulin resistance of tissues and induce insulin-dependent glucose uptake. Pyridoxine hydrochloride (vitamin B6) as coenzyme is involved in metabolic processes, is necessary for the normal functioning of the central and peripheral nervous system. Entering the body, it is phosphorylated, converted to pyridoxal-5-phosphate, is part of the enzymes that carry out decarboxylation and transamination of amino acids. Participates in the exchange of tryptophan, methionine, cysteine, glutamic and other amino acids, lipid and carbohydrate metabolism. Pyridoxine is necessary for the synthesis of? -aminobutyric acid and heme.

Absorption of magnesium lactate in the gastrointestinal tract is slow, not more than 50% of the dose taken internally.
About 25-30% of the absorbed magnesium circulates in the protein-bound state. The absorbed magnesium is excreted by the kidneys, the non-absorbed part is excreted through the intestine. Magnesium overcomes the placental barrier; in a small amount penetrates into breast milk.
Pyridoxine hydrochloride is well absorbed in the gastrointestinal tract, further metabolized in the liver with the formation of pharmacologically active metabolites (pyridoxal phosphate and pyridoxamine phosphate).
The concentration of pyridoxine in plasma is normally 30-80 ng / ml. Most of the pyridoxine is contained in the liver, then in the muscles and brain tissue. The total content of pyridoxine in the body is 167 mg. Pyridoxal phosphate with plasma proteins binds to 90%. The half-life is 15-20 days. It is excreted by the kidneys. Pyridoxal phosphate penetrates the placenta. It is in hemodialysis.

A fixed deficiency of magnesium, isolated or associated with other deficient conditions, accompanied by symptoms such as:

- increased irritability;

- minor sleep disorders;

- gastrointestinal spasms;

- cardiopalmus;

- increased fatigue;

- pain and muscle spasms;

- tingling sensation.


Inside, with food, drinking a glass of water.

Adults are recommended to take 6-8 tablets per day.

Children older than 6 years (body weight over 20 kg) are recommended to take 4-6 tablets per day.

The daily dose should be divided into 2 - 3 doses.
The average course of treatment is 1 month.
Immediately after the normalization of the magnesium level in the blood, the drug should be stopped.


Allergic reactions, abdominal pain, diarrhea, nausea, vomiting, flatulence.


- hypersensitivity to the components of the drug;

- marked renal failure (creatinine clearance less than 30 ml / min);

- phenylketonuria;

- children's age till 6 years;

- deficiency of lactase;

lactose intolerance;

- Glucose-galactose malabsorption (the preparation contains lactose).

With caution: with moderate failure of kidney function, since there is a risk of hypermagnetism.


Magnistad can be used during pregnancy only on the recommendation of a doctor.
Magnesium penetrates into breast milk.
Avoid the use of the drug during lactation.
If necessary, breast-feeding should be discontinued.

The drug should be used with caution in case of moderate renal failure, because there is a risk of hypermagnesemia.

Contraindicated in severe renal failure (creatinine clearance less than 30 ml / min).


Contraindicated in children under 6 years.

Children older than 6 years (body weight over 20 kg) are recommended to take 4-6 tablets per day.
The daily dose should be divided into 2 - 3 doses. The average course of treatment is 1 month.

Magnistad should not be taken on an empty stomach, since it is possible to develop diarrhea.

When combined with tetracyclines, it is necessary to observe an interval of 3 hours between the methods of Magnystad and the preparation of the tetracycline series.When combined with preparations containing phosphates or calcium salts, the interval of 1 h should be observed.

Impact on the ability to drive vehicles and manage mechanisms

Does not affect.


With normal kidney function, oral magnesium intake does not cause toxic reactions.
However, an overdose of magnesium can develop with renal failure.
Symptoms: asystole, bradycardia, central nervous system inhibition, coma, hypotension (syncope), muscle paralysis, polyuria or oliguria, diplopia and blurred vision, shortness of breath.

Treatment: stop taking the drug;
specific - if the level of magnesium in the blood exceeds 10 mmol / l, 10 ml of a 10% calcium gluconate solution should be administered, but not more than 2 times.
Nonspecific - rehydration measures, forced diuresis.

Adrenal insufficiency requires hemodialysis or peritoneal dialysis.


The simultaneous use of drugs containing phosphates or calcium salts can significantly reduce the absorption of magnesium in the gastrointestinal tract.
Magnesium preparations reduce the absorption of tetracycline.
Magnesium weakens the effect of oral thrombolytic agents, reduces the absorption of iron.
Pyridoxine decreases the effectiveness of levodopa.

On prescription.


Store in a dry, dark place at a temperature of no higher than 25 ° C. Keep out of the reach of children.
Shelf life - 3 years.
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