Composition, form of production and packaging
Eye drops 0.3% in the form of a clear or slightly opalescent liquid, colorless or light yellow in color.
1 ml
Lomefloxacin (in the form of hydrochloride) 3 mg
Auxiliary substances: glycerol (glycerin distilled) - 25 mg, disodium edetate - 0.1 mg, benzalkonium chloride - 0.1 mg, sodium hydroxide r-p 1M - to pH 4.8-5.0, water d / u - up to 1 ml.
5 ml - a bottle-droppers polymer (1) - packs cardboard.
INSTRUCTION FOR THE SPECIALIST.
Description of the drug approved by the manufacturer for the printed edition of 2013.
PHARMACHOLOGIC EFFECT
Antimicrobial bactericidal preparation of a broad spectrum of action from the group of fluoroquinolones (a subgroup of difluoroquinolones). Affects the bacterial enzyme DNA-gyrase, which provides supercoiling, forms a complex with its tetramer (subunit of gyrase A2B2) and disrupts transcription and replication of DNA, leads to the death of the microbial cell. It is bactericidal.
ОІ-lactamases produced by pathogens do not affect lomefloxacin activity.
The drug is highly active against gram-negative aerobic microorganisms: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Citrobacter diversus, Klebsiella pneumoniae, Enterobacter cloacae, Proteus vulgaris, Salmonella spp., Shigella spp., Moraxella catarrhalis, Morganella morganii, Haemophilus influenzae, Haemophilus parainfluenzae, Legionella pneumophila.
The drug is moderately sensitive: Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Serratia liquefaciens, Serratia marcescens, Mycobacterium tuberculosis, Chlamydia trachomatis, Hafnia alvei, Citrobacter freundii, Aeromonas hydrophila, Proteus mirabilis, Proteus stuartii, Providencia rettgeri, Providencia alcalifaciens, Klebsiella oxytoca, Klebsiella ozaenae, Enterobacter aerogenes, Enterobacter agglomerans.
The drug is resistant to: Streptococcus spp., Pseudomonas cepacia, Ureaplasma urealyticum, Treponema pallidum, Mycoplasma hominis and anaerobic bacteria.
PHARMACOKINETICS
After instillation, 1 drop every 1 day for 2 days and 5 drops for 3 days T max 90 min, C max 1 Ојg / ml for 2.5 hours. Therapeutic concentration in the cornea, sclera, eyelid, conjunctiva and intraocular fluid It is achieved after 5 instillations in 1 drop at intervals of 5 minutes. The content in the lacrimal fluid after 1-2 instillations is: 40-200 Ојg / ml - after 2 hours, 7-27 Ојg / ml - after 6 hours or more, 3 Ојg / ml - after 24 hours.
INDICATIONS
- bacterial infections of the anterior part of the eye (conjunctivitis, blepharitis, blepharoconjunctivitis, including chlamydial etiology).
DOSING MODE
Adults appoint 1 drop 2-3 times / day in the lower conjunctival sac for 7-9 days. At the beginning of treatment, more frequent use is necessary: ​​5 drops for 20 minutes (1 drop at intervals of 5 minutes) or 1 drop / h for 6-10 hours.
For the treatment of chlamydial conjunctivitis 1 drop of the drug is instilled in the conjunctival sac of the affected eye 2-4 times / day for 1-2 months.
SIDE EFFECT
Local reactions: burning sensation; with prolonged use - the development of secondary fungal infection.
CONTRAINDICATIONS
- Pregnancy;
- the period of lactation (breastfeeding);
- children and adolescence under 18;
- Hypersensitivity to the components of the drug.
PREGNANCY AND LACTATION
Application in pregnancy is not recommended. When appointing during lactation, breastfeeding should be discontinued.
APPLICATION FOR CHILDREN
The drug is contraindicated in childhood and adolescence.
SPECIAL INSTRUCTIONS
During the period of treatment, contact lenses should be avoided.
Impact on the ability to drive vehicles and manage mechanisms
During the period of treatment, care should be taken when driving vehicles and engaging in potentially hazardous activities requiring increased concentration of attention and speed of psychomotor reactions.
OVERDOSE
There is no information about an overdose.
DRUG INTERACTION
There is no data on drug interaction.
TERMS OF RELEASE FROM PHARMACY
The drug is released by prescription.
TERMS AND CONDITIONS OF STORAGE
The drug should be stored out of reach of children, protected from light at a temperature of 15 В° to 25 В° C. Do not freeze! Shelf life - 2 years.
After opening the vial, the shelf life is 1 month.
