Universal reference book for medicines
Product name: LEGALON 140 (LEGALON 140)

Active substance: Cardui mariae fructus

Type: Hepatoprotector

Manufacturer: MADAUS (Germany)
Composition, form of production and packaging
Capsules
hard gelatinous, size 1, with a brown body and lid;
the contents of the capsules are a yellow powder.
1 caps.

dry extract of milk thistle fruit (36-44: 1) 173-186.7 mg,

which corresponds to the content of [DNPH] 140 mg

[HPLC] silymarin in terms of silibinin 108.2 mg

Excipients: polysorbate 80, povidone, mannitol, sodium carboxymethyl starch (type A), magnesium stearate.

The composition of the capsule shell: gelatin, iron oxide red (E172), titanium dioxide (E171), sodium lauryl sulfate, iron oxide black oxide (E172).

10 pieces.
- blisters (2) - packs of cardboard.
10 pieces.
- blisters (3) - packs of cardboard.
10 pieces.
- blisters (6) - packs of cardboard.
INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2011.

PHARMACHOLOGIC EFFECT

Interacts with free radicals in the liver and translates them into less toxic compounds, interrupting the process of lipid peroxidation, prevents the destruction of cellular structures.
In damaged hepatocytes stimulates the synthesis of structural and functional proteins and phospholipids (due to specific stimulation of RNA polymerase A), stabilizes cell membranes, prevents the loss of cell components (transaminases), accelerates the regeneration of liver cells. It inhibits the penetration of some hepatotoxic substances into the cell.
PHARMACOKINETICS

Absorption - low and slow (half-absorption period - 2.2 h), metabolized in the liver by conjugation, T 1/2 - 6 h. It is excreted mainly with bile in the form of glucuronides and sulphates.
Do not cum in the body. There is an intestinal-hepatic circulation.
INDICATIONS

- toxic liver damage (alcoholism, intoxication with halogenated hydrocarbons, heavy metal compounds, medicinal liver damage) and their prevention.

DOSING MODE

Inside, after eating, squeezed a little water.
1 capsule 3 times a day. Maintenance dose - 1 capsule 2 times / day.
SIDE EFFECT

Allergic reactions, rarely - a laxative effect.

CONTRAINDICATIONS

- Hypersensitivity to the components of the drug.

PREGNANCY AND LACTATION

It is not recommended to use the drug during pregnancy and breastfeeding.

DRUG INTERACTION

Not described.

TERMS OF RELEASE FROM PHARMACY

The drug is approved for use as a means of OTC.

TERMS AND CONDITIONS OF STORAGE

Keep the drug in a dark place at a temperature of no higher than 30 ° C.
Keep out of the reach of children.
Shelf life - 5 years.

Do not use after the expiry date printed on the package.

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