Universal reference book for medicines
Product name: LACTOFILTRUM ® (LACTOFILTRUM)

Active substance: lactulose, non appropriate

Type: Enterosorbent, regulating the balance of intestinal microflora

Manufacturer: АВВА РУС (Russia)
Composition, form of production and packaging
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Tablets of dark brown color with white-gray impregnations, capsular, biconvex, with a risk.
1 tab.

lignin hydrolysing 355 mg

lactulose 120 mg

Excipients: croscarmellose sodium - 20 mg, magnesium stearate - 5 mg.

10 pieces.
- packings of cellular contour (1) - packs cardboard.
10 pieces.
- packings cellular planimetric (2) - packs cardboard.
10 pieces.
- packings cellular planimetric (3) - packs cardboard.
10 pieces.
- packings cellular planimetric (6) - packs cardboard.
15 pcs.
- packings cellular planimetric (2) - packs cardboard.
15 pcs.
- packings cellular planimetric (4) - packs cardboard.
30 pcs.
- vials polymeric (1) - packs cardboard.
60 pcs.
- vials polymeric (1) - packs cardboard.
INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2015.

PHARMACHOLOGIC EFFECT

Enterosorbent.
Pharmacological action of the drug Lactofiltrum ® is due to the properties of its active ingredients - lignin and lactulose.
Lignin hydrolyzed - an enterosorbent of natural origin, consisting of products of hydrolysis of wood components, has a high sorption activity and nonspecific detoxification action.
Binds in the intestines and removes from the body pathogenic bacteria and bacterial toxins, medicines, salts of heavy metals, ethanol, allergens, as well as an excess of certain metabolic products, incl. bilirubin, cholesterol, histamine, serotonin, urea, other metabolites responsible for the development of endogenous toxicosis.
Lactulose is a synthetic disaccharide, the molecule of which consists of the remains of galactose and fructose.
In the large intestine, lactulose as a substrate is fermented by normal intestinal microflora, stimulating the growth of bifido- and lactobacilli. As a result of hydrolysis of lactulose in the large intestine, organic acids are formed - lactic, acetic and formic, suppressing the growth of pathogenic microorganisms and thereby reducing the production of nitrogen-containing toxic substances. The described process leads to an increase in osmotic pressure in the lumen of the large intestine and stimulation of peristalsis.
The complex effect of the drug is aimed at normalizing the large intestine microbiocenosis and reducing the intensity of endogenous toxic conditions.

PHARMACOKINETICS

Lignin hydrolyzed is not absorbed, completely eliminated from the intestine within 24 hours.

Lactulose in the stomach and upper intestine is not absorbed and not hydrolyzed.
Hydrolysis of lactulose occurs in the large intestine.
INDICATIONS

- violations of the intestinal microflora, incl.
as a result of antibiotic therapy;
- irritable bowel syndrome (as part of complex therapy);

- hepatitis and cirrhosis of the liver (as part of complex therapy);

- allergic diseases (atopic dermatitis, urticaria) - as part of complex therapy.

DOSING MODE

Tablets are taken orally, if necessary - after preliminary shredding, with water, 1 hour before meals and taking other medications.

Adults and children over 12 years of age are prescribed 2-3 tablets.
3 times / day, children aged 8 to 12 years - 1-2 tablespoons. 3 times / day, children aged 3 to 7 years - 1 tab. 3 times / day, children aged 1 to 3 years - 1/2 tablet 3 times / day.
The average duration of treatment is 2-3 weeks.
Long-term use of the drug and repeated courses of treatment should be carried out only on the advice of a doctor.
SIDE EFFECT

From the digestive system: rarely - flatulence, diarrhea.

Other: allergic reactions.

CONTRAINDICATIONS

- intestinal obstruction;

- gastrointestinal bleeding;

- galactosemia;

- Hypersensitivity to the drug.

With caution should prescribe the drug for exacerbation of peptic ulcer of the stomach and duodenum, atony of the intestine.

PREGNANCY AND LACTATION

Data on the safety of Lactofiltrum ® during pregnancy and lactation are not available.

SPECIAL INSTRUCTIONS

The drug can be used in complex therapy in conjunction with other medicines, subject to the rule of separate admission.

OVERDOSE

Symptoms: constipation, abdominal pain.

Treatment: discontinuation of the drug.

DRUG INTERACTION

It is possible to reduce the therapeutic effect of some simultaneously taken drugs.

TERMS OF RELEASE FROM PHARMACY

The drug is approved for use as a means of OTC.

TERMS AND CONDITIONS OF STORAGE

The drug should be stored in a dry, protected from light, out of reach of children at a temperature of no higher than 30 ° C.
Shelf life - 3 years.
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