Composition, form of production and packaging
The tablets covered with a film membrane of white or almost white color, round, biconcave.
1 tab.
benfotiamine 100 mg
pyridoxine hydrochloride 100 mg
cyanocobalamin 2 Ојg
Excipients: carmellose sodium 4.533 mg, povidone (polyvinylpyrrolidone, povidone K-30) 16.233 mg, microcrystalline cellulose 12.673 mg, talc 4.58 mg, calcium stearate 4.587 mg, polysorbate 80 0.66 mg, sucrose (granulated sugar ) - 206.732 mg.
The composition of the coating: hypromellose (hydroxypropylmethylcellulose) 3.512 mg, macrogol (macrogol 4000, polyethylene oxide-4000) 1.411 mg, povidone (low molecular weight polyvinylpyrrolidone, povidone K-17) 3.713 mg, titanium dioxide 3.511 mg, talc 1.353 mg.
15 pcs. - packings cellular planimetric (2) - packs cardboard.
15 pcs. - packings cellular planimetric (4) - packs cardboard.
INSTRUCTION FOR THE SPECIALIST.
Description of the drug approved by the manufacturer for the printed edition of 2016.
PHARMACHOLOGIC EFFECT
Combined multivitamin preparation. Pharmacological action is determined by the properties of the vitamins that make up its composition.
Benfotiamin - fat-soluble form of thiamine (vitamin B 1 ). Participates in carrying out a nerve impulse.
Pyridoxine hydrochloride (vitamin B 6 ) is involved in the metabolism of proteins, carbohydrates and fats, is necessary for normal, hematopoiesis, central and peripheral nervous system functioning. It provides synaptic transmission, inhibition processes in the central nervous system, participates in the transport of sphingosine, which is part of the nerve shell, participates in the synthesis of catecholamines.
Cyanocobalamin (vitamin B 12 ) is involved in the synthesis of nucleotides, is an important factor in normal growth, hematopoiesis and the development of epithelial cells; is necessary for the metabolism of folic acid and myelin synthesis.
PHARMACOKINETICS
Data on pharmacokinetics are not available.
INDICATIONS
In the complex therapy of the following neurological diseases:
- trigeminal neuralgia;
- neuritis of the facial nerve;
- pain syndrome caused by diseases of the spine (intercostal neuralgia, lumboschialgia, lumbar syndrome, cervical syndrome, cervico-brachial syndrome, radicular syndrome caused by degenerative changes in the spine);
- Polyneuropathy of various etiologies (diabetic, alcoholic).
DOSING MODE
Tablets should be taken after meals, without chewing and washing down with a small amount of liquid.
Adults - 1 tab. 1-3 times / day.
The duration of the course is according to the doctor's recommendation. Do not recommend treatment with high doses of the drug for more than 4 weeks.
SIDE EFFECT
Allergic reactions: itching, urticaria rash.
In some cases: increased sweating, nausea, tachycardia.
CONTRAINDICATIONS
- severe and acute forms of decompensated heart failure;
- childhood;
- Hypersensitivity to the components of the drug.
PREGNANCY AND LACTATION
Kombilipen В® tabs contains 100 mg of vitamin B 6 , so it is not recommended to use the drug during pregnancy and during lactation.
APPLICATION FOR CHILDREN
The use of the drug in childhood is contraindicated.
SPECIAL INSTRUCTIONS
During the use of the drug is not recommended the use of multivitamin complexes, including vitamins of group B.
OVERDOSE
Symptoms: increased symptoms of side effects of the drug.
Treatment: gastric lavage, reception of activated charcoal, the appointment of symptomatic therapy.
DRUG INTERACTION
Levodopa reduces the effect of therapeutic doses of vitamin B 6 .
Vitamin B 12 is incompatible with salts of heavy metals.
Ethanol dramatically reduces the absorption of thiamine.
TERMS OF RELEASE FROM PHARMACY
The drug is released by prescription.
TERMS AND CONDITIONS OF STORAGE
The drug should be stored out of reach of children at a temperature of no higher than 25 В° C. Shelf life - 2 years.
