Universal reference book for medicines
Product name: COMBILIPEN В® (COMBILIPEN)

Active substance: comb.
drug
Type: Complex of B vitamins

Manufacturer: FARMSTANDART-UfaVITA (Russia)
Composition, form of production and packaging
The solution for the / m administration is
transparent, rosy red, with a specific odor.

1 amp.

thiamine hydrochloride 100 mg

pyridoxine hydrochloride 100 mg

cyanocobalamin 1 mg

lidocaine hydrochloride 20 mg

Excipients: benzyl alcohol - 40 mg, sodium tripolyphosphate - 20 mg, potassium hexacyanoferrate - 0.2 mg, sodium hydroxide - up to pH 4.5 В± 0.2, water d / u - up to 2 ml.

2 ml - dark glass ampoules (5) - packings of cellular contour (1) - packs of cardboard.

2 ml - ampoules of dark glass (5) - packings of cellular contour (2) - packs cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2016.

PHARMACHOLOGIC EFFECT

Combined multivitamin preparation.
The effect of the drug is determined by the properties of the vitamins that make up its composition. Neurotropic B vitamins have a beneficial effect on inflammatory and degenerative diseases of the nervous system and the musculoskeletal system.
Thiamine hydrochloride (vitamin B 1 ) is involved in conducting a nerve impulse.

Pyridoxine hydrochloride (vitamin B 6 ) has a vital effect on the exchange of proteins, carbohydrates and fats, is necessary for normal hematopoiesis, the functioning of the central and peripheral nervous system.
It provides synaptic transmission, inhibition processes in the central nervous system, participates in the transport of sphingosine, which is part of the nerve shell, participates in the synthesis of catecholamines.
Cyanocobalamin (vitamin B 12 ) participates in the synthesis of nucleotides, is an important factor in normal growth, hematopoiesis and the development of epithelial cells, is necessary for the metabolism of folic acid and myelin synthesis.

Lidocaine has an anesthetic effect at the injection site, dilates the blood vessels, facilitating the absorption of vitamins.
The local anesthetic effect of lidocaine is due to blockade of potential-dependent Na + channels, which prevents the generation of pulses in the endings of the sensory nerves and pain impulses along nerve fibers.
PHARMACOKINETICS

Data on pharmacokinetics are not available.

INDICATIONS

In the complex therapy of the following neurological diseases:

- trigeminal neuralgia;

- neuritis of the facial nerve;

- pain syndrome caused by diseases of the spine (intercostal neuralgia, lumboschialgia, lumbar syndrome, cervical syndrome, cervico-brachial syndrome, radicular syndrome caused by degenerative changes in the spine);

- Polyneuropathy of various etiologies (diabetic, alcoholic).

DOSING MODE

In severe pain syndrome, it is advisable to start treatment with a / m administration (deep) 2 ml daily for 5-10 days, with a transition in the future either to oral intake of the drug, or to rarer injections (2-3 times / week during 2-3 weeks) with possible continuation of therapy with the oral dosage form.

SIDE EFFECT

Possible: allergic reactions in the form of itching, urticaria;
shortness of breath, Quincke's edema, anaphylactic shock.
In some cases: sweating, tachycardia, acne.

CONTRAINDICATIONS

- severe and acute forms of decompensated heart failure;

- Pregnancy;

- the period of lactation (breastfeeding);

- Children's age (due to lack of data);

- Hypersensitivity to the components of the drug.

PREGNANCY AND LACTATION

The use of the drug during pregnancy and during lactation is not recommended.

APPLICATION FOR CHILDREN

The use of the drug is contraindicated in childhood due to the lack of data.

SPECIAL INSTRUCTIONS

Due to the lack of data, the use of the drug is not recommended in childhood.

OVERDOSE

Symptoms: dizziness, nausea, vomiting, pruritus, urticaria, increased sweating, tachycardia.

Treatment: symptomatic therapy.

DRUG INTERACTION

Vitamin B 1 completely decomposes in solutions containing sulfites is incompatible with oxidizing and reducing substances (mercuric chloride, iodide, carbonate, acetate, tannic acid, iron (III) -ammonium citrate), as well as sodium phenobarbital, riboflavin, benzylpenicillin, dextrose and sodium metabisulfite.

Levodopa reduces the effect of therapeutic doses of vitamin B 6 .

Vitamin B 12 is incompatible with salts of heavy metals, ascorbic acid.

TERMS OF RELEASE FROM PHARMACY

The drug is released by prescription.

TERMS AND CONDITIONS OF STORAGE

The drug should be stored in a place protected from light, inaccessible to children at a temperature of 2 В° to 8 В° C.
Shelf life - 2 years.
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