Universal reference book for medicines
Product name: KESTINE (KESTINE)

Active substance: ebastine

Type: The blocker of histamine H 1 -receptors.
Anti-allergic drug
Manufacturer: NYCOMED DANMARK (Denmark) manufactured by Industrias Farmaceuticas Almirall Prodesfarma (Spain)
Composition, form of production and packaging
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The syrup is transparent, colorless or slightly yellowish, with the smell of anise.
5 ml

ebastin 5 mg

Excipients: lactic acid 85%, glycerol oxystearate, neohesperidin dihydrochalcon, anethole, sodium propyl parahydroxybenzoate, sodium methyl parahydroxybenzoate, glycerol, sorbitol solution 70%, dimethylpolysiloxane, sodium hydroxide, distilled water.

60 ml - bottles of dark glass (1) complete with a measuring device in the form of a syringe - packs of cardboard.

120 ml - bottles of dark glass (1) complete with a measuring device in the form of a syringe - packs of cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2013.

PHARMACHOLOGIC EFFECT

Anti-allergic drug.
After taking the drug inside, the expressed antiallergic effect begins within 1 hour and lasts for 48 hours. After a 5-day course of treatment with Kestin, antihistamine activity persists for 72 hours due to the action of active metabolites. The drug has no pronounced anticholinergic and sedative effect. There was no effect of Kestin on the QT interval of the ECG, even at a dose of 80 mg.
PHARMACOKINETICS

After oral administration, it is rapidly absorbed and almost completely metabolized in the liver, becoming an active metabolite of carabastine.

After a single intake of 5 or 10 mg of C max preparation, carbastine in plasma is achieved after 2.8-3.4 hours and is 108-209 ng / ml.
Fatty foods accelerate absorption (concentration in the blood increases to 50%).
It does not penetrate the hemato-encephalitic barrier.

It is excreted by the kidneys - 60-70%, in the form of conjugates.

With renal insufficiency T 1/2 increases to 23-26 hours, with liver failure - up to 27 hours.

INDICATIONS

- allergic rhinitis seasonal and / or all-the-year-round (caused by household, pollen, epidermal, food, drug allergens);

- urticaria (can be caused by domestic, pollen, epidermal, food, insect, drug allergens, exposure to the sun, cold, etc.);

- Allergic diseases and conditions caused by increased release of histamine.

DOSING MODE

Children from 6 to 12 years: 5 mg (5 ml) once a day.

Children from 12 to 15 years: 10 mg (10 ml) once a day.

Adults and children over 15 years are prescribed 10-20 mg (10-20 ml) once a day.

A daily dose of 20 mg is given on the recommendation of a doctor.

Kestin В® is taken regardless of food intake.

SIDE EFFECT

Headache, dry mouth.
In rare cases - dyspepsia, nausea, insomnia, drowsiness, abdominal pain. Asthenic syndrome, sinusitis.
CONTRAINDICATIONS

- hypersensitivity to the drug;

- pregnancy, the period of breastfeeding.

With caution: with hepatic and / or kidney failure, in childhood (up to 6 years).

PREGNANCY AND LACTATION

The safety of the use of Kestin in pregnant women is not investigated, therefore, it is not recommended to take Kestin during pregnancy.
Nursing mothers are not recommended to take Kestin, since the release of ebastin into breast milk has not been studied.
APPLICATION FOR FUNCTIONS OF THE LIVER

With caution in kidney failure.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS

With caution in liver failure.

If the liver function is impaired, the daily dose should not exceed 10 mg.

APPLICATION FOR CHILDREN

With caution to children under 6 years.

SPECIAL INSTRUCTIONS

If the liver function is impaired, the daily dose should not exceed 10 mg.

Use with caution in patients with increased QT-interval, hypokatieia.

Impact on the ability to drive vehicles and manage mechanisms

Kestin В® does not affect the ability to drive vehicles and mechanisms.

OVERDOSE

There is no special antidote for the drug.
In case of an overdose, it is recommended to wash the stomach, monitor vital body functions. Symptomatic treatment.
DRUG INTERACTION

It is not recommended to appoint Kestin В® concomitantly with ketoconazole and erythromycin.
Kestin does not interact with theophylline, indirect anticoagulants, cimetidane, diazepam, ethanol, and ethanol-containing drugs.
TERMS OF RELEASE FROM PHARMACY

Without recipe.

TERMS AND CONDITIONS OF STORAGE

At a temperature of 15 В° to 25 В° C in a dark place out of the reach of children.
Shelf life - 2 years
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