Composition, form of production and packaging
? Tablets of white color, round, flat, with a facet, with the designation of the "Alcaloid" mark on one side and the fault line on the other.
1 tab.
paracetamol 250 mg
propiphenazone 210 mg
caffeine 50 mg
Auxiliary substances: magnesium stearate 13.5 mg, sodium lauryl sulfate 1.5 mg, sodium starch glycolate 14.5 mg, silicon dioxide colloid 2.5 mg, povidone 12.5 mg, calcium dihydrogen phosphate 21.1 mg, cellulose microcrystalline 28.5 mg, croscarmellose sodium 9.6 mg, glyceryl dibehenate 6.3 mg.
6 pcs. - Strips (1) - packs of cardboard.
6 pcs. - Strips (2) - packs of cardboard.
10 pieces. - Strips (1) - packs of cardboard.
INSTRUCTION FOR THE SPECIALIST.
Description of the drug approved by the manufacturer for the printed edition of 2014.
PHARMACHOLOGIC EFFECT
Kaffetin В® sk is a combined preparation of analgesic action.
Paracetamol and propifenazone have an analgesic and antipyretic effect. The mechanism of action is associated with inhibition of prostaglandin synthesis. The presence of caffeine in combined analgesic drugs increases the absorption of components.
The combination of the drug ensures the achievement of a satisfactory analgesic effect, and the use of small amounts included in the components reduces the risk of side effects.
PHARMACOKINETICS
The pharmacokinetic characteristics of the combined preparations are not significant, since the drugs are not intended for the treatment of chronic diseases and therefore are applied as required or in the form of short-term courses. All active components of the drug Kaffetin В® sk have a similar pharmacokinetic profile, which justifies the rationality of the analgesic combination. Absorbed very quickly and their maximum concentrations in the plasma are reached in 30-60 minutes after administration.
Metabolised in the liver and excreted in the urine.
During the biotransformation of paracetamol, a small amount of the toxic metabolite N-acetil-p-benzo-quinoneimine is created, which can manifest violations in the liver.
INDICATIONS
Pain syndrome of moderate severity of various genesis: headache and toothache, migraine, neuralgia, myalgia, post-traumatic pains, arthralgia, algodismenorea, fever in influenza infections.
DOSING MODE
Inside, adults - 1 tablet 3-4 times a day. For severe pain, taking 2 tablets at once is recommended. The maximum daily dose is 6 tablets.
Children older than 7 years are prescribed 1 / 4-1 / 2 tablets, 1-4 times a day.
The duration of taking the drug is no more than 5 days. An increase in the daily dose of the drug or the duration of treatment is possible only after consulting a doctor.
SIDE EFFECT
Leukopenia, agranulocytosis, nausea, gastralgia, vomiting, increased activity of "liver" transaminases, increased excitability (especially in children), allergic reactions (skin rash, Quincke's edema, itching, urticaria).
CONTRAINDICATIONS
Increased individual sensitivity to the components of the drug; hepatic and / or renal insufficiency; deficiency of glucose-6-phosphate dehydrogenase; leukopenia;violation of hematopoiesis; increased excitability; insomnia; angina on coronarosclerosis; pregnancy and lactation; children's age (up to 7 years).
PREGNANCY AND LACTATION
Caffetin В® sk is contraindicated for use in pregnancy and during lactation.
APPLICATION FOR FUNCTIONS OF THE LIVER
Contraindicated in renal failure.
APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
Contraindicated in liver failure.
With prolonged use of the drug, control of the functional state of the liver is necessary.
APPLICATION FOR CHILDREN
Contraindicated in children under 7 years. Use with caution in children older than 7 years.
APPLICATION IN ELDERLY PATIENTS
With caution: the elderly.
SPECIAL INSTRUCTIONS
With continued use of the drug, control of peripheral blood and the functional state of the liver is necessary. During treatment, you should stop using alcohol-containing beverages (increased risk of gastrointestinal bleeding). Excessive consumption of caffeinated products (coffee, tea) on the background of taking the drug may cause symptoms of an overdose. Taking the drug may make it difficult to establish a diagnosis for acute abdominal pain syndrome. In patients suffering from bronchial asthma, pollinosis, there is an increased risk of developing hypersensitivity reactions.
Carefully. Elderly, children's age, glaucoma.
Influence on the ability to drive vehicles, mechanisms. Kaffetin В® sk does not affect the ability to drive vehicles and machines.
OVERDOSE
Symptoms: nausea, vomiting, ringing in the ears, pain in the stomach, sweating, pallor of the skin, tachycardia. If you suspect a poisoning, you should immediately seek medical help.
Assist: the affected person should rinse the stomach and prescribe adsorbents (activated charcoal).
DRUG INTERACTION
Avoid combination of the drug with barbiturates, antiepileptics, zidovudine, rifampicin and alcohol-containing beverages (the risk of hepatotoxic effect increases).
Under the influence of paracetamol, the time of chloramphenicol elimination is increased by 5 times. Metoclopramide accelerates the absorption of paracetamol. With repeated admission, paracetamol can enhance the effect of anticoagulants (dicumarin derivatives). Caffeine accelerates the absorption of ergotamine.
TERMS OF RELEASE FROM PHARMACY
The drug is approved for use as a means of OTC.
TERMS AND CONDITIONS OF STORAGE
Store at a temperature not exceeding 25 В° C. Keep out of the reach of children.
Shelf life - 3 years. Do not use after the expiration date printed on the package.