Universal reference book for medicines
Product name: IOD (IOD)

Active substance: iodine

Type: Antiseptic for external use

Manufacturer: ТУЛЬСКАЯ ФАРМАЦЕВТИЧЕСКАЯ ФАБРИКА (Russia)
Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

PHARMACHOLOGIC EFFECT
Elementary iodine has pronounced antimicrobial properties.
For preparations of elementary iodine, a pronounced local irritant effect on the tissue is characteristic, and in high concentrations - a cauterizing effect. Local action is due to the ability of elementary iodine to precipitate tissue proteins. Preparations that cleave elementary iodine have a much less pronounced irritant effect, and iodides have locally irritating properties only at very high concentrations.
The nature of the resorptive action of preparations of elemental iodine and iodides is the same.
The most pronounced effect with resorptive action iodine preparations have on the functions of the thyroid gland. With iodine deficiency, iodides contribute to the restoration of impaired thyroid hormone synthesis. With a normal iodine content in the environment, iodides inhibit the synthesis of thyroid hormones, reduce the sensitivity of the thyroid gland to the TTG of the pituitary gland, and block its secretion by the pituitary gland. The effect of iodine preparations on metabolism is manifested by the intensification of dissimilation processes. With atherosclerosis, they cause a slight decrease in the concentration of cholesterol and beta-lipoproteins in the blood; in addition, increase the fibrinolytic and lipoproteinase activity of blood serum and slow the rate of blood clotting.
Accumulating in syphilitic gums, iodine promotes their softening and resorption.
However, the accumulation of iodine in tuberculosis foci leads to an intensification of the inflammatory process in them. Isolation of iodine excretory glands is accompanied by irritation of glandular tissue and increased secretion. This is due to expectorant action and stimulation of lactation (in small doses). However, in large doses of iodine preparations can cause suppression of lactation.
PHARMACOKINETICS
When exposed to skin or mucous membranes, 30% turns into iodides, and the rest into active iodine.
Partially absorbed. The absorbed part penetrates into tissues and organs, is selectively absorbed by the thyroid gland. It is allocated mainly by the kidneys, intestines, sweat and mammary glands.
INDICATIONS
For external use: infectious and inflammatory skin lesions, trauma, wounds, myalgia.

For topical use: chronic tonsillitis, atrophic rhinitis, purulent otitis, trophic and varicose ulcers, wounds, infected burns, fresh thermal and chemical burns of I-II degree.

For oral administration: prevention and treatment of atherosclerosis, tertiary syphilis.

DOSING MODE
With external use of iodine, the damaged skin is treated.

For oral administration, the dose is set individually, depending on the indications and age of the patient.

Locally used for washing lacunae and supratonsillar spaces - 4-5 procedures at intervals of 2-3 days, for irrigation of the nasopharynx - 2-3 times a week for 2-3 months, for instillation in the ear and rinsing - for 2-4 weeks;
In surgical practice and with burns, moistened napkins are applied to the affected surface as needed.
SIDE EFFECT
With external application: rarely - skin irritation;
with prolonged use on extensive wound surfaces - iodism (rhinitis, urticaria, Quincke's edema, salivation, lacrimation, acne).
Ingestion: skin allergic reactions, tachycardia, nervousness, sleep disorders, excessive sweating, diarrhea (in patients older than 40 years).

CONTRAINDICATIONS
Hypersensitivity to iodine.
For oral administration - pulmonary tuberculosis, nephritis, nephrosis, adenomas (including thyroid gland), furunculosis, acne, chronic pyoderma, hemorrhagic diathesis, urticaria, pregnancy, children under 5 years.
PREGNANCY AND LACTATION
Contraindicated for oral administration during pregnancy.

APPLICATION FOR FUNCTIONS OF THE LIVER
At nephritis and nephrosis is contraindicated for oral administration.

APPLICATION FOR CHILDREN
Contraindicated for oral administration to children under 5 years.

SPECIAL INSTRUCTIONS
With prolonged use, the phenomena of iodism are possible.

DRUG INTERACTION
Pharmaceutically incompatible with essential oils, solutions of ammonia, white sedimentary mercury (an explosive mixture is formed).
Alkaline or acidic medium, the presence of fat, pus, blood weaken antiseptic activity. Weaken the hypothyroid and strugogenic effects of lithium preparations.
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