Universal reference book for medicines
Product name: INGARON ® (INGARON)

Active substance: interferon gamma

Type: Interferon.
Immunomodulating drug with antiviral action
Manufacturer: NPP FARMAKLON (Russia)
Composition, form of production and packaging
Lyophilizate for the preparation of a solution for w / m and / or introduction of
white, in the form of loose or porous mass, hygroscopic.

1 f.

interferon gamma 100,000 IU

- "500 000 IU

"-" 1,000,000 IU

- "- 2 000 000 IU

Excipients: mannitol.

Vials (1) - packs of cardboard.

Vials (1) - packings, cellular planimetric (1) - packs cardboard.

Vials (1) - packings cassette outline (1) - packs cardboard.

Vials (5) - packs of cardboard.

Vials (5) - packings, cellular planimetric (1) - packs cardboard.

Vials (5) - packings cassette outline (1) - packs cardboard.

Vials (10) - packs of cardboard.

Vials (10) - packings, cellular planimetric (1) - packs cardboard.

Vials (10) - packings cassette outline (1) - packs cardboard.

Vials (20) - packs cardboard.

Vials (20) - packings cellular planimetric (1) - packs cardboard.

Vials (20) - packings cassette outline (1) - packs cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2012.

PHARMACHOLOGIC EFFECT

Recombinant human gamma interferon, consisting of 144 amino acid residues, is deprived of the first three amino acid residues of Cys-Tyr-Cys, replaced by Met.Molecular weight 16.9 kDa.
It was obtained by microbiological synthesis in a recombinant strain of Escherichia coli and purified by column chromatography. Specific antiviral activity on cells (human fibroblasts) infected with vesicular stomatitis virus is 2? 10 7 U / mg protein.
Interferon gamma (immune interferon) is the most important pro-inflammatory cytokine.
the producers of which in the human body are natural killer cells, CD4 Th1 cells and CD8 cytotoxic suppressor cells. Receptors for interferon gamma have macrophages, neutrophils, natural killer cells, cytotoxic T-lymphocytes. Interferon gamma activates effector functions of these cells, in particular their microbicide, cytotoxicity, production of cytokines, superoxide and nitroxide radicals, thereby causing the death of intracellular parasites. Interferon gamma inhibits the B-cell response, interleukin-4, inhibits the production of IgE and the expression of CD23 antigen. It is an inducer of apoptosis of differentiated B cells, giving rise to autoreactive clones. Suppresses the suppressive effect of interleukin-4 on interleukin-2-dependent proliferation and lymphokine generation of activated killers.
Activates the production of acute inflammatory phase proteins, enhances the expression of the C 2 and C 4 gene components of the complement system.

Unlike other interferons, it increases the expression of MHC antigens of both I and II classes on different cells, and induces the expression of these molecules even on those cells that do not express them constitutively.
This improves the efficiency of antigen presentation and the ability to recognize them by T lymphocytes. Interferon gamma blocks the replication of viral DNA and RNA, the synthesis of viral proteins and the assembly of mature viral particles. Interferon gamma has a cytotoxic effect on virus-infected cells.
Interferon gamma blocks the synthesis of? -TGF, responsible for the development of pulmonary fibrosis and liver.

INDICATIONS

- treatment of chronic viral hepatitis C, chronic viral hepatitis B, HIV / AIDS infection and pulmonary tuberculosis in complex therapy;

- prevention of infectious complications in patients with chronic granulomatous disease;

- treatment of oncological diseases in complex therapy as an immunomodulator, incl.
in combination with chemotherapy;
- treatment of genital herpesvirus infection and herpes zoster (Herpes zoster) in monotherapy;

- treatment of urogenital chlamydia in complex therapy;

- treatment of chronic prostatitis in complex therapy;

- treatment of anogenital warts (human papilloma virus) and prevention of recurrence of the disease.

DOSING MODE

The drug is given in / m or s / c.
The contents of the vial are dissolved in 2 ml of water for injection. The dose of the drug is set individually.
For treatment of patients with chronic viral hepatitis B, chronic viral hepatitis C, as well as HIV / AIDS infection and pulmonary tuberculosis , the average daily dose for adults is 500 00 ME.
The drug is administered 1 time / day, daily or every other day. The course of treatment is from 1 to 3 months, if necessary, after 1-2 months, the course of treatment is repeated.
For the prevention of infectious complications in patients with chronic granulomatous disease , the average daily dose for adults is usually 500 000 ME.
The drug is administered 1 time / day, daily or every other day. The course of treatment - 5-15 injections, if necessary, the course is prolonged or repeated after 10-14 days.
For the treatment of cancer, the average daily intake for adults is 500,000 ME.
The drug is administered 1 time / day, every other day.
For the treatment of genital herpesvirus infection, herpes zoster (Herpes zoster) and urogenital chlamydia, the average daily dose for adults is 500,000 IU.
The drug is administered 1 time / day, s / c, every other day. The course of treatment is 5 injections.
For the treatment of chronic prostatitis, the daily dose is 100 000 ME.
The drug is administered 1 time / day, s / c, every other day. The course of treatment is 10 injections.
For the treatment of anogenital warts, the daily dose is 100,000 IU.
The drug is administered 1 time / day, after the cryodestruction, every other day. The course of treatment is 5 injections.
SIDE EFFECT

Local reactions: local soreness at the site of the sc administration in the form of mild pain of a lomiting nature (like an overtrained muscle) and hyperemia.

The use of high doses over 1,000,000 IU may be accompanied by the development of influenza-like syndrome: headache, weakness, fever, joint pain.
Slightly expressed symptoms do not require pharmacological correction. With the expressed phenomena - the docking with the help of paracetamol.
CONTRAINDICATIONS

- Pregnancy;

- autoimmune diseases;

- diabetes;

- individual intolerance to interferon gamma or any other component of the drug.

PREGNANCY AND LACTATION

The drug is contraindicated in pregnancy.

OVERDOSE

Data on overdose are not provided.

DRUG INTERACTION

Data on drug interactions are not provided.

TERMS OF RELEASE FROM PHARMACY

The drug is released by prescription.

TERMS AND CONDITIONS OF STORAGE

The drug should be stored in a dry, protected from light, out of reach of children, at a temperature of 2 ° to 10 ° C.
Do not freeze. Shelf life - 2 years.
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