Universal reference book for medicines
Name of the preparation: IMODIUM ® PLUS (IMODIUM ® PLUS)

Active substance: loperamide, simeticone

Type: An antidiarrhoeal symptomatic drug

Manufacturer: JOHNSON & JOHNSON (Russia) manufactured by JANSSEN-CILAG (Italy)
Composition, form of production and packaging
?
Tablets chewing white, round, flat, with engraving " IMO " on one side, with the smell of vanilla and mint.
1 tab.

loperamide hydrochloride 2 mg

simethicone 125 mg

Excipients: sucrose, microcrystalline cellulose, polymethacrylate, cellulose acetate, sorbitol, dextrates (hydrated), vanilla-mint (natural-synthetic) flavor, sodium saccharinate, stearic acid, calcium phosphate.

4 things.
- blisters (1) - packs of cardboard.
6 pcs.
- blisters (2) - packs of cardboard.
INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2011.

PHARMACHOLOGIC EFFECT

Antidiarrhoeal drug.

Loperamide binds to opioid receptors in the intestinal wall, which leads to inhibition of propulsive peristalsis, increased resorption of water and electrolytes.Loperamide does not change the physiological microflora of the intestine and increases the tone of the anal sphincter.

Simethicone is an inert surface-active compound.
Has a defoaming effect, and therefore facilitates the symptoms associated with diarrhea (flatulence, abdominal discomfort, spastic pain).
Imodium ® Plus does not have a central effect.

PHARMACOKINETICS

Suction

Loperamide is well absorbed from the intestine.
Simethicone is not absorbed from the digestive tract.
Metabolism

Loperamide is subjected to the effect of "first passage", while almost completely metabolized in the liver and excreted with bile in the form of conjugated metabolites.Due to the intensive metabolism, the concentration in the blood plasma of the unchanged loperamide is very low.

Excretion

T 1/2 loperamide is an average of 10.8 h (range from 9 to 14 h).
Metabolites of loperamide are excreted with feces.
INDICATIONS

- Diarrhea of ​​any etiology and associated symptoms (flatulence, abdominal discomfort, spastic pain).

DOSING MODE

The drug is prescribed for adults and children over 12 years in the initial dose of 2 tablets, then - 1 tab.
after each loose stool. The maximum daily dose is 4 tablets.Duration of reception - no more than 2 days.
When using the drug in elderly patients, dose adjustment is not required.

When using the drug in patients with impaired renal function, a dose reduction is not required.

SIDE EFFECT

The following side effects were classified as follows: very often (? 10%), often (? 1%, but <10%), infrequently (? 0.1%, but <1%), rarely (? 0.01%, but <0.1% ), very rarely (<0.01%), including isolated cases.

Allergic reactions: very rarely - skin rash, hives, itching;
in isolated cases - angioedema, bullous eruptions (including Stephen-Johnson syndrome), erythema multiforme, toxic epidermal necrolysis, anaphylactic shock, anaphylactoid reactions.
On the part of the digestive system: very rarely - distortion of taste, abdominal pain, nausea, constipation, bloating, vomiting, indigestion, intestinal obstruction, megacolon (including a variant of toxic course).

On the part of the genitourinary system: in isolated cases - urinary retention.

From the side of the central nervous system: very rarely - dizziness;
in isolated cases - drowsiness.
Reports of adverse reactions during clinical and post-marketing studies of loperamide are characteristic of diarrheal syndrome (dry mouth, abdominal pain, abdominal discomfort, nausea, vomiting, constipation, bloating, fatigue, drowsiness, dizziness).
Therefore, it is rather difficult to establish a reliable relationship between taking the drug and the above symptoms.
CONTRAINDICATIONS

- acute dysentery, which is characterized by bloody stools or high fever (as a monotherapy);

- bacterial enterocolitis caused by Salmonella spp., Shigella spp., Campylobacter spp .;

acute ulcerative colitis;

- pseudomembranous colitis due to antibiotic therapy;

- children's age till 12 years;

- Hypersensitivity to the components of the drug.

PREGNANCY AND LACTATION

The use of Imodium Plus during pregnancy (especially in the first trimester) is possible in case of strict indications.

A small amount of loperamide penetrates into breast milk.
Therefore, it is not recommended to use the drug during breastfeeding.
At present, there is no teratogenic or embryotoxic effect of loperamide and simethicone.

APPLICATION FOR FUNCTIONS OF THE LIVER

When using the drug in patients with impaired renal function, a dose reduction is not required.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS

With caution should be appointed Imodium plus patients with impaired liver function.

APPLICATION FOR CHILDREN

Contraindication: children under 12 years.

APPLICATION IN ELDERLY PATIENTS

When using the drug in elderly patients, dose adjustment is not required.

SPECIAL INSTRUCTIONS

With caution should be appointed Imodium ® Plus patients with impaired liver function, t.
the metabolism of the "first passage" is slowed. In these cases, monitoring of the patient's health status is necessary.
Since the treatment with Imodium® Plus is symptomatic, it is necessary to carry out etiotropic and rehydration therapy simultaneously.

If there is no clinical improvement within 48 hours, Imodium Plus should be discontinued.
The patient should be informed that in this situation it is necessary to consult a doctor.
Imodium ® Plus is not recommended in cases where peristalsis should be avoided.

If there is constipation and / or bloating during treatment with Imodium Plus, the drug should be discontinued immediately.

Use in Pediatrics

The drug is not prescribed for children under the age of 12 years .

Impact on the ability to drive vehicles and manage mechanisms

Imodium ® Plus does not affect the speed of mental and physical reactions.
However, patients who, after taking the drug, are drowsy, tired or dizzy, should refrain from driving the car and working with potentially dangerous mechanisms.
OVERDOSE

Includes an overdose due to impaired liver function.

Symptoms: CNS depression (stupor, impaired coordination of movements, drowsiness, miosis, muscle tone increase, respiratory depression) and paralytic ileus.
In children, CNS depression may occur more often than in adults.
Treatment: antidote - naloxone.
Since loperamide has a longer action than naloxone (1-3 h), additional administration of naloxone may be required. To detect possible oppression of the central nervous system, it is necessary to monitor the patient for 48 hours.
DRUG INTERACTION

With the exception of drugs that have a similar pharmacological effect, due to the mutual enhancement of effects, interaction with other drugs has not been established.

TERMS OF RELEASE FROM PHARMACY

The drug is approved for use as a means of OTC.

TERMS AND CONDITIONS OF STORAGE

The drug should be stored out of reach of children at a temperature of 15 ° to 30 ° C.
Shelf life - 3 years.
Alphabetical index of medicines:
A  B  V  G  D  E  J
Z  I  Y  K  L  M  N
O  P  R  S  T  U  F
H  C  CH  SH  E  U  Y
Rambler's Top100
Privacy policy:
Copyright 2009 - 2017. Universal reference book of medicines. All rights reserved.
When using site materials, an active hyperlink is required!