Universal reference book for medicines
Product name: ZOVIRAX ® (ZOVIRAX)

Active substance: aciclovir

Type: Antiviral drug for topical application in ophthalmology

Manufacturer: WELLCOME FOUNDATION (Great Britain) manufactured by DRAXIS PHARMA (Canada)
Composition, form of production and packaging
Eye ointment 3%
soft, homogeneous, white or almost white, translucent, oily, with a weak characteristic odor, which does not contain grains, lumps and foreign particles.

1 g

Acyclovir (micronized) 30 mg

Excipients: Vaseline white.

4.5 g - tubes with a polyethylene nozzle (1) - packs cardboard.

INSTRUCTION FOR THE SPECIALIST.

The description of the drug was approved by the manufacturer for the 2006 print edition.

PHARMACHOLOGIC EFFECT

Antiviral drug for topical application in ophthalmology.
Highly active against Herpes simplex virus type 1 and 2 and Varicella zoster.
After entering the virus-infected cells, acyclovir is phosphorylated to the active acyclovir triphosphate by the action of viral thymidine kinase.
Acyclovir triphosphate acts as a nonspecific inhibitor and substrate for the viral DNA polymerase and prevents the synthesis of viral DNA without damaging the host cells.
PHARMACOKINETICS

After instillation of ophthalmic ointment, acyclovir is rapidly absorbed by the epithelium of the cornea and by eye-eye tissues, as a result of which the concentration of the drug necessary for suppressing the virus is created in the intraocular fluid.
Acyclovir is defined in urine in a small concentration, not having a therapeutic value.
INDICATIONS

- keratitis caused by the Herpes simplex virus type 1 and 2.

DOSING MODE

For adults and children, a preparation in the form of an ointment strip 10 mm long should be placed in the lower conjunctival sac.
Multiplicity of application 5 times / day with an interval of about 4 hours. Therapy should be continued for another 3 days after the healing.
SIDE EFFECT

Side effects are given in accordance with the frequency of occurrence during clinical trials: very often -> 10%;
often from> 1% to <10%; sometimes from> 0.1% to <1%; rarely from> 0.01% to <0.1%; very rarely - <0.01%.
Allergic reactions: very rarely - immediate-type hypersensitivity reactions (including angioedema).

From the side of the organ of vision: sometimes - spot superficial keratopathy (does not require cessation of treatment and disappears without consequences);
often - mild burning (transient with time); sometimes - conjunctivitis; rarely - blepharitis.
CONTRAINDICATIONS

- Hypersensitivity to acyclovir or valaciclovir.

PREGNANCY AND LACTATION

The use of the drug during pregnancy is possible in the event that the intended use for the mother exceeds the potential risk to the fetus.

When entering the systemic bloodstream of the mother, acyclovir penetrates into breast milk, but the amount of the drug that a child can receive with ophthalmic ointment is very small.

SPECIAL INSTRUCTIONS

There may be a slight burning sensation after applying ointment ophthalmic Zoviraks, passing spontaneously.

During therapy with the drug, you should not wear contact lenses.

OVERDOSE

Overdosage ointment ophthalmic Zovirax is unlikely.

DRUG INTERACTION

The drug interaction ointment ophthalmic Zovirax is not described.

TERMS OF RELEASE FROM PHARMACY

The drug is released by prescription.

TERMS AND CONDITIONS OF STORAGE

The drug should be stored out of the reach of children at a temperature of no higher than 25 ° C.
Shelf life - 5 years.
Eye ointment should be used within 1 month after opening the package.

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