Universal reference book for medicines
Product name: ZEDEX (ZEDEX)

Active substance: bromhexine, dextromethorphan, non appropriate

Type: Antitussive and expectorant drug

Manufacturer: WOCKHARDT (India)
Composition, form of production and packaging
The syrup is
thick, clear, orange with a smell of menthol.

10 ml

bromohexine hydrochloride 8 mg

dextromethorphan hydrobromide 10 mg

ammonium chloride 100 mg

Auxiliary substances: levomenthol 5 mg, sucrose 6000 mg, dextrose 3,500 mg, benzoic acid 7 mg, sodium benzoate 3.5 mg, sodium saccharinate 30 mg, propylene glycol 363.3 mg, vanillin 1 mg, dye sunset yellow 0.67 mg, fruit flavoring 0.012 ml, water purified to 10 ml.

100 ml - polyethylene bottles (1) complete with plastic cup 10 ml - packs cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2013.

PHARMACHOLOGIC EFFECT

Combined drug.

Bromhexine has mucolytic (secretolitic), expectorant and weak antitussive effect.
Mucolytic effect is associated with depolymerization and liquefaction of mucoprotein and mucopolysaccharide fibers.
Dextromosthorfan increases the sensitivity threshold of the cough center of the medulla oblongata, without leading to the depression of the respiratory center, has an antitussive and sedative effect, does not cause an addictive effect to the drug and does not possess an analgesic effect.

Ammonium chloride has expectorant properties.

INDICATIONS

- to relieve the symptoms of "colds", flu, ARVI, accompanied by a cough.

DOSING MODE

Adults and children over 12 years: inside 2 teaspoons 2-3 times a day.

Children from 6 to 12 years: inside by 1 / 2-1 teaspoon 3-4 times a day.

SIDE EFFECT

Dyspeptic phenomena, exacerbation of peptic ulcer, allergic reactions (skin rash, rhinitis, etc.), increased serum transaminase levels, drowsiness, sleep disturbance, increased excitability (especially in children).

CONTRAINDICATIONS

- hypersensitivity to the components of the drug;

- pregnancy and lactation;

- peptic ulcer (in the stage of exacerbation);

- simultaneous reception of other drugs containing substances that are part of Zedex;

- Children under 6 years.

Carefully

Hepatic and / or renal failure, bronchial asthma.

PREGNANCY AND LACTATION

Contraindicated in pregnancy and lactation.

APPLICATION FOR FUNCTIONS OF THE LIVER

Use with caution in renal failure.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS

Use with caution in liver failure.

APPLICATION FOR CHILDREN

Contraindicated for children under 6 years.
Use according to indications in children older than 6 years.
SPECIAL INSTRUCTIONS

During treatment should refrain from drinking alcohol.

Impact on the ability to drive vehicles and manage mechanisms

Caution is observed when performing work that requires concentration of attention, increased speed of motor and mental reactions.

OVERDOSE

Dangerous for life overdose in the application of Bromhexine in humans are unknown.

Symptoms include nausea, vomiting, and other gastrointestinal disorders.
Dextromethorphan can cause excitation of the central nervous system.
Treatment: gastric lavage, reception of activated charcoal, symptomatic therapy.

DRUG INTERACTION

Zedex can be prescribed concurrently with other drugs used in the treatment of bronchopulmonary diseases.
Zedex is not prescribed concomitantly with antitussive agents (including those containing codeine).
Bromhexine, which is part of Zedex, promotes the penetration of antibiotics (erythromycin, cephalexin, oxytracycline, ampicillin, amoxicillin) into the lung tissue, but its combined use with salicylates, phenylbutazone and oxyphenbutazone can cause severe irritation of the gastric mucosa.
Alcohol, which is part of the syrup, can change the effect of other medicines.
Because
the drug includes dextromethorphan, it is contraindicated simultaneous use with MAO inhibitors (possibly action on the central nervous system and pronounced respiratory depression), amiodarone (may inhibit the metabolism of dextromethorphan in the liver and increase its toxicity), antidepressants serotonin reuptake inhibitors (fluoxetine, paroxetine). Dextromethorphan can potentiate the analgesic effect of opioids.
TERMS OF RELEASE FROM PHARMACY

Without recipe.

TERMS AND CONDITIONS OF STORAGE

Store in a dry place, in tightly closed bottles at a temperature not exceeding 30 ° C.
Keep out of the reach of children. Shelf life - 3 years.
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