Universal reference book for medicines
Product name: GELATINOL (GELATINOL)

Active substance: gelatin

Type: Plasma Substitute

Manufacturer: SAMSON-MED (Russia)
Composition, form of production and packaging
Solution for infusions in a solution of sodium chloride 0.9%
100 ml

gelatine 8 g

450 ml - bottles for blood substitutes (15) - cardboard boxes.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2014.

PHARMACHOLOGIC EFFECT

Gelatinol is a hypertonic colloidal solution with anti-shock effect.
The therapeutic effect of gelatin is related to the high colloid osmotic pressure created by it in the lumen of the blood vessels (220-290 mm of water). An increase in the volume of circulating plasma (more than 1.5 times the outgoing value) and an increase in blood pressure occurs not only due to the introduced solution, but also in connection with the additional interstitial fluid entering the vascular bed. Gelatinol increases the rate of erythrocyte sedimentation, which normalizes on the average by the 20th day; does not violate the protein, carbohydrate and pigmentary functions of the liver, improves microcirculation.
PHARMACOKINETICS

Gelatinol quickly leaves the bloodstream, which is explained by the presence of a large number of low molecular weight fractions (after 2 hours, approximately 20% of the injected drug remains in the blood).
The bulk of the drug is excreted from the body by the kidneys (on the first day about 40% of the drug, in the second - 1%).The rest penetrates from the vascular bed into the tissue, where it is exposed to tissue enzymes - proteases and is included in the protein metabolism.
INDICATIONS

- as a plasma-substituting agent in the treatment of shock (traumatic, burn, hemorrhagic and toxic 1-2 levels);

- to fill the apparatus of artificial circulation, with the purpose of detoxification with burns and other conditions, accompanied by intoxication.

DOSING MODE

The drug is administered intravenously or intraarterially, regardless of the crani group.

In case of acute blood loss and shock , a jet intravenous injection is recommended with a subsequent transition to a drop (50-60 drops per minute) to maintain blood pressure at the physiological level.
The dose of the drug depends on the patient's condition. If necessary, gelatin is administered repeatedly. At the same time, no more than 2 liters of solution can be introduced. Children - at the rate of no more than 15-25 mg / kg body weight.
For extracorporeal circulation, gelatinol is used together with donor erythrocytes in various ratios and with the addition of other solutions.

SIDE EFFECT

Albuminuria (within 1-2 days after administration).
In very rare cases, the occurrence of allergic reactions of varying severity. It should be borne in mind the danger of developing anaphylactic shock in patients at risk who have a history of intolerance to drugs, including sera, vaccines, and intravenous fluids, plasma-substituting drugs, including dextran.
If undesirable reactions occur, stop the infusion immediately and remove needles from the vein, administer antihistamines, vasoconstrictors and glucocorticosteroids, vasopressor agents used to treat anaphylactic shock.

CONTRAINDICATIONS

- hypersensitivity to the drug;

- Acute and chronic nephritis.

APPLICATION FOR FUNCTIONS OF THE LIVER

The drug is contraindicated in patients with acute and chronic nephritis.

SPECIAL INSTRUCTIONS

Before transfusing gelatin, the doctor should perform a visual inspection of the bottles intended for infusion.
The preparation is considered suitable for use provided that the sealing is kept tight, there is no cracks on the bottles. The drug should be clear and not contain suspended matter. The results of visual inspection of bottles and label data (name of the drug, manufacturer, serial number) must be recorded in the patient's medical history. When applying gelatin, a biological sample is mandatory: after the first 5 drops are injected, the infusion is stopped for 3 minutes, and then another 30 drops are added and the infusion is stopped again for 3 minutes, in the absence of an undesired reaction, the administration of the drug is continued. The results of the test must be recorded in the medical history.
DRUG INTERACTION

Compatible with nitrogen-containing preparations for parenteral nutrition, vitamins, glucose solution in various proportions, blood and its components.

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