Universal reference book for medicines
Name of the preparation: DIAZOLIN (DIAZOLIN)

Active substance: mebhydrolin

Type: The blocker of histamine H 1 -receptors.
Anti-allergic drug
Manufacturer: OZONE (Russia)
Description of the active substance:
This information is a reference and it is not enough that the drug was prescribed by a doctor.
.
PHARMACHOLOGIC EFFECT
The blocker of histamine H 1 -receptors, the derivative of ethylenediamine.
Has antiallergic, antipruritic, antiexudative, and also weak sedation. It has m-cholinoblocking properties.
PHARMACOKINETICS
After oral administration, it is rapidly absorbed from the digestive tract.
Bioavailability is 40-60%. Virtually does not penetrate the BBB. Metabolised in the liver by methylation. Causes the induction of microsomal liver enzymes. It is excreted by the kidneys.
INDICATIONS
Hay fever, hives, eczema, pruritus, allergic rhinitis, allergic conjunctivitis, skin reaction after an insect bite;
bronchial asthma (as part of combination therapy).
DOSING MODE
Adults and children over 10 years of age - 100-300 mg / day.
The daily dose for children aged 5-10 years is 100-200 mg; 2-5 years - 50-150 mg; up to 2 years - 50-100 mg.
SIDE EFFECT
From the digestive system: rarely - dry mouth, dyspeptic phenomena due to irritation of the gastric mucosa.

From the side of the central nervous system and peripheral nervous system: dizziness, paresthesia, increased fatigue, tremors, drowsiness.

From the hemopoietic system: in isolated cases - granulocytopenia, agranulocytosis.

From the side of the urinary system: in isolated cases - dysuria.

CONTRAINDICATIONS
Hypertrophy of the prostate gland, angle-closure glaucoma, peptic ulcer of the stomach and duodenum, inflammatory diseases of the digestive tract in the phase of exacerbation;
hypersensitivity to mebhydrolin, pyloric stenosis, epilepsy, cardiac arrhythmias (having vagolytic action, can improve AV-conductivity and promote the development of supraventricular arrhythmias), pregnancy, lactation.
PREGNANCY AND LACTATION
Mebhydroline is contraindicated for use in pregnancy and lactation (breastfeeding).

APPLICATION FOR FUNCTIONS OF THE LIVER
Use with caution in renal failure (correction of dose and intervals between doses may be required).

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
Use with caution in liver failure (may require dose adjustment and intervals between doses).

APPLICATION FOR CHILDREN
Children over 10 years of age - 100-300 mg / day.
The daily dose for children aged 5-10 years is 100-200 mg; 2-5 years - 50-150 mg; up to 2 years - 50-100 mg.
SPECIAL INSTRUCTIONS
Use with caution in hepatic and / or renal failure (dosage and interval between doses may be required).

Impact on the ability to drive vehicles and manage mechanisms

During the treatment period, one should refrain from engaging in potentially dangerous activities requiring increased attention and speed of psychomotor reactions (driving vehicles or working with mechanisms).

DRUG INTERACTION
Mebhydroline increases the effect of sedatives and ethanol.

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