Universal reference book for medicines
Product name: DERMARAEF (DERMARAEF)

Active substance: nonappropriate

Type: The drug with anti-inflammatory and tissue regeneration-improving action for external use

Manufacturer: BELMEDPREPARATY (Republic of Belarus)
Composition, form of production and packaging
Ointment for external use of
light yellow color with a weak specific odor.

100 g

Bien 5 g

Auxiliary substances: geranium oil (fraction 1) 0.1 g, sunflower oil 10 g, emulsion wax 10 g, glycerol 5 g, glyceryl monostearate 1 g, methyl parahydroxybenzoate 0.15 g, propyl parahydroxybenzoate 0.05 g, purified water up to 100 g.

15 g - aluminum tubes (1) - cardboard packs.

25 grams - tubes of aluminum (1) - packs of cardboard.

30 g - aluminum tubes (1) - cardboard packs.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2011.

PHARMACHOLOGIC EFFECT

Bien - a mixture of ethyl esters of polyunsaturated fatty acids, obtained from the lipids of the filamentous fungus Entomophthora virulenta, the family Entomophthoraceae, the class Zygomycetes, the E. coli strain stabilized by alpha-tocopherol acetate (vitamin E).
Bien for 90-95% consists of higher fatty acids.
The composition of biene includes: ethyl esters of alpha-linolenic acid (omega-3);
linoleic acid (omega-6); gamma-linolenic acid (omega-6); arachidonic acid (omega-6); eicosidic acid (omega-6); eicosatrienic acid (omega-6); palmitic acid (omega-7); palmitoleic acid (omega-9); oleic acid (omega-9), as well as ethyl esters of stearic acid and myristic acid. Unsaturated fatty acids included in the composition of Bien, incl. Essential (linoleic, alpha-linolenic and arachidonic) are important components of biomembranes and sources of eicosanoids - universal bioregulators of the functional activity of cells and tissues. Biene is characterized by a balanced ratio of polyunsaturated fatty acids of the omega-6 and omega-3 series, has a cytoprotective effect, enhances reparative processes.
Essential polyunsaturated fatty acids (PUFA) and their derivatives - eicosanoids - have a modulating effect on the development of hyperreactivity and the formation of allergic inflammation, proliferative processes.
Arachidonic acid metabolite prostaglandin PGE 2 at low concentrations inhibits the migration of leukocytes and the release of inflammatory mediators from mast cells. Eicosanoids, which exert a dose-dependent anti-inflammatory effect, also include PGE 1 , PGT 2a , PGD 2 .
Ointment has an anti-inflammatory effect and stimulates reparative processes in the skin (reduces flushing and swelling, reduces the burning sensation of the skin, contributes to the epithelization of the wound defect).

PHARMACOKINETICS

Virtually not absorbed through the skin, does not enter the systemic bloodstream.
Through damaged skin is absorbed in small amounts.
INDICATIONS

- as part of complex therapy, for symptomatic treatment of skin manifestations of dermatitis (atopic, allergic, contact), eczema (true, seborrheic).

DOSING MODE

Outwardly.
Ointment is applied to the damaged or inflamed skin area with a thin layer 1-2 times / day. The course of treatment is 10-15 days. The course of treatment can be prolonged on the recommendation of a doctor.
SIDE EFFECT

Allergic reactions (hives, itching), burning in the place of application.
If side effects occur, stop using the ointment.
CONTRAINDICATIONS

- bacterial, viral and fungal skin diseases (including herpes simplex, chicken pox, skin tuberculosis, actinomycosis);

- eczema in the stage of exacerbation with the phenomena of wetness;

- syphilitic skin lesions;

- Pregnancy;

- lactation period;

- children's age till 18 years;

- Hypersensitivity to the components of the drug.

PREGNANCY AND LACTATION

The safety of the use of the drug during pregnancy and during lactation has not been studied.
The use of the drug is contraindicated in pregnancy and lactation.
APPLICATION FOR CHILDREN

Contraindicated in children under 18 years.

SPECIAL INSTRUCTIONS

Impact on the ability to drive vehicles and manage mechanisms

The drug does not affect the ability to drive vehicles and other potentially dangerous mechanisms.

OVERDOSE

Cases of overdose with the use of the drug is not described.

DRUG INTERACTION

Cases of interaction with other drugs are unknown.

TERMS OF RELEASE FROM PHARMACY

The drug is released by prescription.

TERMS AND CONDITIONS OF STORAGE

The preparation should be stored in a dry, protected from light place at a temperature not exceeding 8 ° С.
Keep out of the reach of children.
Shelf life - 2 years.

Do not use after the expiration date printed on the package.

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