Universal reference book for medicines
Name of the drug: DEPRIM ® (DEPRIM ® )

Active substance: Hyperici herba

Type: Phytopreparation with antidepressant activity

Manufacturer: SANDOZ (Slovenia) produced by LEK dd (Slovenia)
Composition, form of production and packaging
Deprim ®

?
The tablets covered with a cover of green color, round, biconcave.
1 tab.

dry standardized extract of St. John's wort (Hypericum perforatum) 60 mg,

in t.ch.
Hypericin (total) 300 μg
Excipients: lactose, microcrystalline cellulose, talc, magnesium stearate, silicon dioxide colloid.

Sheath composition: hydroxypropylmethylcellulose, polyethylene glycol, talc, carnauba wax, glaze green, glaze blue, titanium dioxide (E171).

10 pieces.
- packings cellular planimetric (3) - packs cardboard.
Deprim ® forte

?
Capsules hard gelatinous, opaque, green; the contents of capsules are compact granules, greenish-brown or grayish-brown in color with a characteristic odor, size 0.
1 caps.

dry standardized extract of St. John's wort (Hypericum perforatum) 425 mg,

in t.ch.
hypericin (total) 1 mg
Auxiliary substances: lactose monohydrate, cellulose, calcium hydrophosphate dihydrate, silicon dioxide colloid, magnesium stearate, talc, gelatin, sodium lauryl sulfate, water, dyes (titanium dioxide E171, chlorophyll-copper complex E141), purified water.

10 pieces.
- blisters (2) - packs of cardboard.
INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2011.

PHARMACHOLOGIC EFFECT

Sedative phytopreparation.
The main active substances of St. John's wort - hypericin, pseudo-hypericin, hyperforin and flavonoids - improve the functional state of the central and autonomic nervous system.
Deprim ® improves mood, normalizes sleep, increases mental and physical activity.

PHARMACOKINETICS

Data on the pharmacokinetics of the drug Deprim ® are not available.

INDICATIONS

- decreased mood;

- Depressive conditions of mild and moderate severity, accompanied by anxiety (including those associated with climacteric syndrome);

- Hypersensitivity to weather changes.

DOSING MODE

Adults and children over 12 years of age are prescribed 1 tab.
3 times / day or 1 capsule 1 time / day (regularly at the same time); if necessary, the dose can be increased to 2 capsules / day (in 2 divided doses). Children aged 6 to 12 years - under medical supervision, 1-2 tablets / day in the morning and afternoon.
The optimal effect is achieved with regular intake of the drug for several weeks.
The therapeutic effect of the drug Deprim ® is manifested 10-14 days after the start of the treatment.
If you miss a single dose, the drug should be taken as soon as possible.
If the time of taking the next dose of the drug is appropriate, no additional dose should be taken to compensate for the missed dose. Do not take two doses of the drug at the same time.
The drug should be taken orally, washed down with water.

SIDE EFFECT

On the part of the digestive system: nausea, vomiting, constipation.

From the side of the central nervous system: a feeling of fatigue, anxiety.

Allergic reactions: hyperemia of the skin, itchy skin.

Dermatological reactions: in persons with increased sensitivity to sunlight, simultaneous administration of the drug and sunbaths can cause burns (photosensitization).

CONTRAINDICATIONS

- severe depression;

- Children under 6 years of age (for coated tablets);

- Children under 12 years (for capsules);

- Hypersensitivity to the components of the drug.

PREGNANCY AND LACTATION

Despite the lack of data on the harmful effects of the drug, taking Deprima during pregnancy and during lactation is possible only if the expected benefit for the mother exceeds the potential risk to the fetus or the baby.

APPLICATION FOR CHILDREN

Contraindication: children under 6 years of age (for coated tablets);
children under 12 years (for capsules). Children aged 6 to 12 years - under medical supervision, 1-2 tablets / day in the morning and afternoon.
SPECIAL INSTRUCTIONS

The patient should be warned that if there is no therapeutic effect within 4-6 weeks after the start of treatment, stop taking Deprim and consult a doctor.

Patients taking the drug should avoid exposure to sunlight and UV irradiation (including a solarium).

Patients taking the drug Deprim ® should refrain from drinking alcohol.

OVERDOSE

Symptoms: an increase in the described side effects, general weakness, lethargy, drowsiness.

Treatment: cancellation of the drug, activated charcoal.

Acute poisoning with St. John's wort has not been observed in humans.

DRUG INTERACTION

Deprim ® activates microsomal oxidation (cytochrome P450), so caution should be given to the drug while taking anticonvulsants, antidepressants (serotonin reuptake inhibitors), tricyclic antidepressants, MAO inhibitors, antimigraine drugs (tryptans), oral hormonal contraceptives, cardiac glycosides (in including digoxin), theophylline, cyclosporine, indinavir, reserpine.

With the simultaneous use of Deprim ® can enhance the action of funds for general anesthesia and opioid analgesics.

TERMS OF RELEASE FROM PHARMACY

The drug is approved for use as a means of OTC.

TERMS AND CONDITIONS OF STORAGE

The drug should be stored out of reach of children at a temperature of no higher than 25 ° C.
Shelf life - 3 years.
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