Universal reference book for medicines
Name of the preparation: DESOXYNAT

Active substance: nonappropriate

Type: Immunomodulator

Manufacturer: ФАРМЗАЩИТА НПЦ (Россия)
Composition, form of production and packaging
Solution for external and local use 0.25%
transparent, colorless, without foreign inclusions.

1 ml

sodium deoxyribonucleate 2.5 mg

Excipients: sodium chloride, water d / and.

50 ml - bottles.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2014.

PHARMACHOLOGIC EFFECT

Deoxynate activates cellular and humoral immunity.

Deoxynate has a therapeutic effect for ulcerative necrotic lesions of the skin and mucous membranes of various locations.

The use of the drug Dezoksinat in the form of dressings, applications and rinses has an analgesic effect, reduces the manifestation of the inflammatory reaction, activates the growth of granulations and epithelium.

With suppuration at the regeneration stage, deoxynate leads to faster healing.

Promotes an increase in engraftment of autografts on burn surfaces, as well as allografts in the plastic of defects in the maxillofacial region.

The use of deoxynate is not accompanied by toxic and allergic reactions.

PHARMACOKINETICS

Dezosinat at local application is quickly absorbed and distributed in organs and tissues with the participation of the endolymphatic pathway.
In the phase of intensive drug delivery to the blood, a redistribution occurs between the plasma and the formed elements of the blood, in parallel with the metabolism and excretion.
Deoxynate is metabolized in the body.
The final metabolites are xanthine, hypoxanthine, beta-alanine, acetic, propionic and uric acids, which are excreted from the gastrointestinal tract.
Excreted from the body (in the form of metabolites) by the kidneys by bi-exponential dependence and, in part, through the gastrointestinal tract.

INDICATIONS

- Primary, late radiation ulcers and thermal skin burns of II-III severity;

- Acute radial pharyngeal syndrome;

- trophic ulcers;

- violation of the integrity of the mucous membrane of the oral cavity, nose, vagina, rectum;

- Decubital ulcers in the oral cavity and on the skin;

- complications associated with cytotoxic therapy (stomatitis, pharyngo esophagitis, gingivitis, uvulitis, enterocolitis, vulvovaginitis, paraproctitis);

- when preparing tissues for auto- or allotransplantation and during transplant engraftment.

DOSING MODE

The drug is prescribed to children from the first day of life and adults.

For the treatment of skin lesions, apply dressing dressings with a solution of Deoxynate, replaceable 3-4 times a day.

With lesions of the oral mucosa , rinses are made with a solution of Deoxynate (4 times a day for 5-15 ml with subsequent ingestion).

In the vagina Dezoksinat is injected on a tampon, in the rectum - in an enema (20-50 ml).

The duration of the course of treatment is until the signs of inflammation and epithelization of the skin and mucous membranes disappear persistently (4-10 days).

SIDE EFFECT

With topical application, Deoxynate does not cause side effects.

CONTRAINDICATIONS

- hypersensitivity to sodium deoxyribonucleate or any other component of the drug.

APPLICATION FOR CHILDREN

Assign to children from the first day of life



SPECIAL INSTRUCTIONS

Ineffective in extremely severe forms of lesions, extensive deep necrosis, attributed to the IV degree of severity.

OVERDOSE

Not detected.

DRUG INTERACTION

It is not compatible with ointments on fat basis and hydrogen peroxide (Н 2 0 2 ).

TERMS OF RELEASE FROM PHARMACY

On prescription.

TERMS AND CONDITIONS OF STORAGE

At temperatures from +5 to +10 ° С.
Keep out of the reach of children. Shelf life - 3 years.
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