Universal reference book for medicines
Product name: DHK CONTINUS (DHC CONTINUS)

Active substance: dihydrocodeine

Type: Actually an opioid receptor agonist.
Analgesic
Manufacturer: BARD PHARMACEUTICALS (UK)
Description of the active substance:
This information is a reference and it is not enough that the drug was prescribed by a doctor.
.
PHARMACHOLOGIC EFFECT
Opioid analgesic and antitussive drug of central action.
The main effects of dihydrocodeine are due to interaction with opioid receptors. The severity of the analgesic effect is estimated as moderate - inferior to morphine, but superior to codeine. When taken orally, the duration of the action is 4-5 hours.
PHARMACOKINETICS
After ingestion, C max is reached after 1.2-1.8 hours. Bioavailability is about 20%, probably due to the effect of "first passage" through the intestinal wall and through the liver.

Dihydrocodeine is metabolized in the liver with the participation of the CYP2D6 isoenzyme to form dihydromorphine, which has a pronounced analgesic activity, although the effect of dihydrocodeine is due mainly to the unmodified substance.
In addition, partially dihydrocodeine is metabolized with the participation of CYP3A4 to nordihydrocodeine.
Dihydrocodeine is excreted in the urine in unchanged form and in the form of metabolites, including glucuronic conjugates.
T 1/2 is 3.5-5 hours.
INDICATIONS
Pain of moderate and significant intensity of various origin (including in the postoperative period, with trauma, in oncology practice).

DOSING MODE
Take inside at a dose of 30 mg, every 4-6 hours. For pain of considerable intensity, the dose can be increased to 40-80 mg 3 times / day.

As an antitussive drug used in a dose of 10 mg every 4-6 hours.

SIDE EFFECT
On the part of the digestive system: nausea, vomiting, constipation.

From the side of the central nervous system: drowsiness, dizziness.

CONTRAINDICATIONS
Hypersensitivity to dihydrocodeine and codeine.

SPECIAL INSTRUCTIONS
With prolonged use, it is possible to develop a drug dependence that is similar in its manifestations to codeine dependence.

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