Universal reference book for medicines
Product name: DALERON C (DALERON C)

Active substance: ascorbic acid, paracetamol

Type: Analgesic-antipyretic

Manufacturer: KRKA (Slovenia)
A typical clinical and pharmacological article
This information is a reference and it is not enough that the drug was prescribed by a doctor.
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PHARMACHOLOGIC EFFECT
Combined drug.

Paracetamol has an analgesic and antipyretic effect.

Ascorbic acid is involved in the regulation of oxidation-reduction processes, carbohydrate metabolism, blood clotting, tissue regeneration, in the synthesis of steroid hormones;
increases the body's resistance to infections, reduces vascular permeability, reduces the need for vitamins B 1 , B 2 , A, E, folic acid, pantothenic acid. It improves paracetamol tolerance and extends its action (slowing its excretion).
INDICATIONS
- a febrile syndrome on the background of catarrhal diseases;

- pain syndrome (mild and moderate): arthralgia, myalgia, neuralgia, migraine, dental and headache, algodismenorea;
pain with injuries, burns.
DOSING MODE
Inside.
Single dose for adults and children (with a body weight of more than 50 kg) - 1 tab. or 10-15 mg / kg (in terms of paracetamol), the maximum daily dose - 4 tab; children 6-12 years - 1/2 table., Maximum daily dose - 2 tablets.
The course of treatment - no more than 10 days.

Before use, the tablet is dissolved in 100-200 ml of boiled water.

With liver failure, the daily dose is reduced by reducing the single dose and / or the frequency of administration.

SIDE EFFECT
Allergic reactions (skin rash, itching, hives, angioedema), nausea, epigastric pain;
anemia, thrombocytopenia, agranulocytosis.
With prolonged use in large doses - hepatotoxic effect, hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia;
nephrotoxicity (renal colic, glucosuria, interstitial nephritis, papillary necrosis).
CONTRAINDICATIONS
hypersensitivity;

- gastrointestinal hemorrhage;

- portal hypertension;

- kidney failure;

- Pregnancy (I and III trimesters);

- lactation period;

- deficiency of glucose-6-phosphate dehydrogenase.

C caution: erosive-ulcerative lesions of the gastrointestinal tract (in the phase of exacerbation), hepatic insufficiency, congenital hyperbilirubinemia (Gilbert syndrome, Dubin-Johnson and Rotor syndrome), alcoholism.

PREGNANCY AND LACTATION
Contraindications: pregnancy (I and III trimesters);
lactation period.
APPLICATION FOR FUNCTIONS OF THE LIVER
Contraindication is renal failure.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
C with caution: hepatic insufficiency.

With liver failure, the daily dose is reduced by reducing the single dose and / or the frequency of administration.

APPLICATION FOR CHILDREN
There is no data on the use in children under the age of 6 years.

The dose for children 6-12 years is 1/2 table. The maximum daily dose is 2 tablets.

SPECIAL INSTRUCTIONS
With hyperthermia, lasting more than 3 days and pain syndrome - more than 5 days, a doctor's consultation is required.

Distorts the results of laboratory tests evaluating the concentration of glucose and uric acid in the plasma.

Do not use concomitantly with other drugs containing paracetamol, as well as other non-narcotic analgesics, NSAIDs (eg metamizole, acetylsalicylic acid, ibuprofen), barbiturates, antiepileptic drugs, rifampicin, chloramphenicol.

Simultaneous use of other drugs should be agreed with the doctor.

Patients with diabetes should take into account that in 1 packet of the drug contains almost 3.8 g of sucrose.

People who are prone to ethanol use should consult a doctor before starting treatment with the drug, since paracetamol can have a damaging effect on the liver.

OVERDOSE
Symptoms (due to paracetamol): pallor of the skin, decreased appetite, nausea, vomiting;
hepatonecrosis (the severity of necrosis due to intoxication directly depends on the degree of overdose). Toxic effect in adults is possible after taking more than 10-15 g of paracetamol: increased activity of hepatic transaminases, an increase in prothrombin time (12-48 hours after administration); a detailed clinical picture of liver damage manifests itself after 1-6 days. Rarely, liver failure develops at a lightning speed and can be complicated by renal insufficiency (tubular necrosis).
Treatment: the introduction of donors of SH-groups and precursors of the synthesis of glutathione - methionine - 8-9 hours after an overdose and N-acetylcysteine ​​- after 12 hours.

The need for additional therapeutic measures (further introduction of methionine, intravenous injection of N-acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after its administration.

DRUG INTERACTION
Stimulants of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, which allows the development of severe intoxication with small overdoses.

Inhibitors of microsomal oxidation (cimetidine) reduce the risk of hepatotoxic action of the drug.

Ethanol promotes the development of acute pancreatitis.

Reduces the effectiveness of uricosuric medicines.

With a decrease in the rate of gastric emptying (propanthelin), the action of the drug slows down, while accelerating (metoclopramide) starts to act faster.

Increases the toxicity of chloramphenicol.

May enhance the effect of indirect anticoagulants.

TERMS OF RELEASE FROM PHARMACY
The drug is approved for use as a means of OTC.

TERMS AND CONDITIONS OF STORAGE
Store in a dry place, protected from light, out of reach of children, at a temperature of 15-25 ° C.

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