Universal reference book for medicines
Product name: D-PANTHENOL (D-PANTHENOL)

Active substance: dexpanthenol

Type: Preparation, improving trophic and tissue regeneration, for external use

Manufacturer: JADRAN Galenski Laboratorij (Croatia)
Composition, form of production and packaging
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The cream for external use is 5% homogeneous, white, with a specific odor.
1 g

dexpanthenol 50 mg

Auxiliary substances: ketomacrogol 40 mg, cetearyl octanoate 50 mg, cetanol 40 mg dimethicone 5 mg glyceryl monostearate 40 mg, propylene glycol 50 mg, methyl parahydroxybenzoate 0.7 mg, propyl parahydroxybenzoate 0.3 mg, purified water 723.8 mg , flavoring Seaside 2026 - 0.2 mg.

25 grams - tubes of aluminum (1) - packs of cardboard.

50 g - aluminum tubes (1) - packs of cardboard.

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Ointment for external use 5% homogeneous, light yellow color, with a characteristic smell of lanolin.
1 g

dexpanthenol 50 mg

Auxiliary substances: phenonide - 4 mg, lanolin - 160 mg, beeswax white - 50 mg, paraffin white soft - 210.8 mg, dimethicone - 5 mg, emulsifier LANETTE SX - 20 mg, propylene glycol - 20 mg, butylhydroxyanisole 0.1 mg, butylhydroxytoluene 0.1 mg, decamethylcyclopentasiloxane 20 mg, magnesium sulfate heptahydrate 5 mg, protebin B 295 mg, purified water 160 mg.

25 grams - tubes of aluminum (1) - packs of cardboard.

50 g - aluminum tubes (1) - packs of cardboard.

INSTRUCTION FOR THE SPECIALIST.

The product description was approved by the manufacturer for the 2009 print edition.

PHARMACHOLOGIC EFFECT

A drug that improves tissue regeneration for external use.

Dexpanthenol is a derivative of pantothenic acid, which is a water-soluble vitamin B, required as a component of coenzyme A for carbohydrate, protein and fat metabolism.
It plays an important role in the processes of acetylation in gluconeogenesis, the release of energy from carbohydrates, the synthesis and cleavage of fatty acids, the synthesis of sterols and steroid hormones, acetylcholine.
Pantothenic acid is necessary to maintain the normal function of the epithelium, increasing the need for it is noted in cases of damage to the skin or tissues, in this case, local deficiency of pantothenic acid can be compensated for by local application of D-Panthenol ointment.

Stimulates skin regeneration, normalizes cellular metabolism, increases the strength of collagen fibers.

It has a regenerating, mild anti-inflammatory effect, nourishes and softens the skin.

Excipients improve the therapeutic properties of the ointment.

PHARMACOKINETICS

Low molecular weight of dexpanthenol, hydrophilicity and low polarity make it possible to penetrate active substances into all layers of the skin.

When topical application is rapidly absorbed and converted to pantothenic acid, binds to plasma proteins (mainly with beta-globulin and albumin).

INDICATIONS

- in children - diaper dermatitis, scratches, minor irritations after exposure to the sun, ultraviolet and X-rays, for the treatment and prevention of diaper rash;

- cracks and inflammation of the nipples in nursing mothers;

- Violations of the integrity of the skin caused by mechanical, chemical, temperature factors or after surgery (burns of various origins / including sunny /, scratches, abrasions, wounds, decubitus, poorly healing skin grafts, aseptic postoperative wounds);

- inflammatory processes on the skin, dermatitis, furuncles, trophic ulcers of the lower extremities, skin care around the tracheostist, gastrostom, colostrum;

- treatment and prevention of the effects of adverse effects on the skin of environmental factors (including cold, wind, humidity).

DOSING MODE

Cream or ointment is applied a thin layer on the affected area, gently rubbing, 2-4 times / day (if necessary more often).
In case of application on the infected skin surface, it should be pretreated with an antiseptic.
Nursing mothers lubricate the nipple with ointment after each feeding.

Breast children are given ointment after each change of underwear or water treatment.

SIDE EFFECT

Side effects were not observed when used according to the indications and in the recommended doses.

CONTRAINDICATIONS

Possible: hypersensitivity to the components of the drug.

PREGNANCY AND LACTATION

Possible application for indications.

APPLICATION FOR CHILDREN

The drug is used in children according to the indications.

SPECIAL INSTRUCTIONS

Treatment of trophic ulcers and poorly healing skin grafts should be performed under the supervision of a physician.

Do not apply to wet surfaces.

OVERDOSE

At present, no cases of an overdose of D-Panthenol have been reported.

DRUG INTERACTION

Drug interaction of the drug D-Panthenol is not described.

TERMS OF RELEASE FROM PHARMACY

The drug is approved for use as a means of OTC.

TERMS AND CONDITIONS OF STORAGE

The drug should be stored out of the reach of children at a temperature of no higher than 25 ° C.
The shelf life of the cream is 1.5 years, the ointment is 2 years.
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