Universal reference book for medicines
Product name: GEMODEZ-8000 (HAEMODEZ-8000)

Active substance: comb.
drug
Type: Preparation with detoxification action for parenteral use

Manufacturer: BIOSINTEZ (Russia) BIOTEK group MFPPK (Russia)
Composition, form of production and packaging
Solution for infusion
100 ml

povidone (polyvinylpyrrolidone) low molecular weight medical with a molecular weight of 8000 ± 2000 6 g

sodium chloride 550 mg

potassium chloride 42 mg

calcium chloride 50 mg

magnesium chloride anhydrous 500 μg

sodium hydrogen carbonate 23 mg

200 ml - bottles for blood substitutes (1) - packs cardboard.

400 ml - bottles for blood substitutes (1) - packs cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2010.

PHARMACHOLOGIC EFFECT

The action of Hemodeza-8000 is due to the ability of low molecular weight polyvinylpyrrolidone to bind toxins circulating in the blood and quickly remove them from the body.
Hemodeza-8000 differs from Hemodesis by the lower molecular weight of polyvinylpyrrolidone. The decrease in the molecular weight of the polymer accelerates the excretion of it by the kidneys from the body and improves the detoxification properties of the preparation. It increases renal blood flow, increases glomerular filtration and increases diuresis.
PHARMACOKINETICS

Metabolic transformations in the body are not affected.
Quickly excreted by the kidneys, within 4 hours 80% are output, and after 12-24 hours - completely.
INDICATIONS

- shock (post-traumatic, postoperative, burn, hemorrhagic);

- intoxication (toxic diseases of the digestive tract: dysentery, dyspepsia, salmonellosis);

- as a means of detoxification in the postoperative period with peritonitis;

- liver disease, accompanied by the development of liver failure;

- intestinal obstruction;

- thyrotoxicosis;

- burn disease;

acute radiation sickness;

- sepsis;

- pneumonia;

- acute phase of myocardial infarction;

- hemolytic disease of newborns;

- intrauterine infection and toxemia of newborns;

- Toxicosis of pregnant women.

DOSING MODE

Intravenously drip (40 - 80 cap / min), through a device with a filter and a polymer needle to connect to the container.

The dose depends on the age of the patient and the severity of intoxication.

Single dose:

for adults - 200-500;

for children - 5-10 ml / kg.

maximum single dose for:

infants - 50-70 ml;

2-5 years - 100 ml;

5-10 years - 150 ml;

10-15 years - 200 ml.

The drug is administered once or repeatedly (up to 2 times / day) for 1-10 days, depending on the severity of intoxication.
In acute gastrointestinal infections, burn and radiation diseases are administered 1-2 times / day; with hemolytic disease and toxemia of newborns - 2-8 times / day (daily or every other day); with large focal myocardial infarction (in 1 day) - 200 ml once, with complications for 2 days - 200 ml.
SIDE EFFECT

With the slow introduction of Haemodesis-8000, complications do not usually arise.
Introduction with increased speed can cause a decrease in blood pressure, tachycardia, difficulty breathing and require the introduction of vasoconstrictor and cardiac agents, calcium chloride. In some patients, allergic reactions may occur up to the development of anaphylactic shock. In these cases, immediately stop the infusion, conduct symptomatic therapy (introduce antihistamines, cardiotonic drugs, glucocorticoids, vasopressive drugs).
CONTRAINDICATIONS

- intracranial hypertension;

- hemorrhagic stroke;

- condition after traumatic brain injury;

- cardiovascular insufficiency IIb-III degree;

- respiratory insufficiency;

- severe allergic reactions;

- thromboembolism;

- oliguria;

anuria;

- acute nephritis;

- bronchial asthma;

- phlebothrombosis;

- Hypersensitivity to the drug.

APPLICATION FOR FUNCTIONS OF THE LIVER

Contraindications: oliguria;
anuria; acute nephritis.
APPLICATION FOR CHILDREN

According to the testimony.

SPECIAL INSTRUCTIONS

With extensive burns combined with the introduction of plasma, albumin, gamma globulin.
Before starting the infusion, the doctor must check the integrity and integrity of the package. The drug should be clear, free of sediment, sediment and mold. The results of a visual examination are recorded in the medical history. Before administration, the solution is warmed to body temperature.
OVERDOSE

In case of an overdose, the drug should be withdrawn and symptomatic therapy should be performed.

TERMS OF RELEASE FROM PHARMACY

On prescription.

TERMS AND CONDITIONS OF STORAGE

At a temperature not exceeding 20 ° C.
In a place inaccessible to children. Shelf life - 3 years. Single and repeated freezing at temperatures up to minus 45 ° C does not affect the quality of the drug.
Non-wetting of the inner surface of bottles is not a contraindication to the use of the drug.

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