Universal reference book for medicines
Product name: Gastal ® (GASTAL ® )

Active substance: magnesium hydroxide, non appropriate

Type: Antacid preparation

Manufacturer: PLIVA HRVATSKA (Croatia)
Composition, form of production and packaging
?
Tablets for resorption (mint) white or almost white, round with a smooth surface and a facet, with a mint flavor.
1 tab.

aluminum hydroxide-magnesium carbonate gel 450 mg

magnesium hydroxide 300 mg

Auxiliary substances: lactose monohydrate 111.5 mg, mannitol 110 mg, pregelatinized starch 32 mg, colloidal dioxide 2 mg, croscarmellose sodium A 50 mg, aspartame 2.5 mg, magnesium stearate 6 mg, mint flavor 11890- 71-6 mg.

6 pcs.
- blisters (4) - packs of cardboard.
6 pcs.
- blisters (8) - packs of cardboard.
?
Resolving tablets (cherry) are white or almost white in color, round, with a smooth surface and a bevel, with a cherry flavor.
1 tab.

aluminum hydroxide-magnesium carbonate gel 450 mg

magnesium hydroxide 300 mg

Auxiliary substances: lactose monohydrate - 112 mg, mannitol - 112 mg, pregelatinized starch - 32 mg, colloidal dioxide silicon 2 mg, croscarmellose sodium type A 50 mg, aspartame 2 mg, magnesium stearate 6 mg, cherry flavor E9407963 - 4 mg.

6 pcs.
- blisters (4) - packs of cardboard.
6 pcs.
- blisters (8) - packs of cardboard.
INSTRUCTION FOR THE SPECIALIST.

The product description was approved by the manufacturer for the 2009 print edition.

PHARMACHOLOGIC EFFECT

Gastal is a combined antacid preparation for oral administration.
Reduces the increased acidity of gastric juice to the physiological level and eliminates dyspeptic disorders by neutralizing the excess of hydrochloric acid in the stomach. The constituent Gastalum magnesium hydroxide and aluminum hydroxide provide a quick and long-lasting neutralization, which determines the antacid effect.
The antacid effect of the drug manifests itself immediately after taking Gastal tablets and lasts about 2 hours. One tablet of Gastal neutralizes about 21.5 mmol of hydrochloric acid.
Gastal inhibits the effects of pepsin, lysolecithin and bile acids, thus also eliminating gastric function disorders.
Gastalum in addition to the antacid effect activates protective and regenerative mechanisms in the gastric mucosa.
The cytoprotective effect caused by aluminum ions includes stimulation of the secretion of mucus and sodium hydrogen carbonate in the stomach, the accumulation of epidermal growth factor in the lesion focus, an increase in the concentration of phospholipids in the stomach, and other mechanisms.
PHARMACOKINETICS

Gastal has no systemic effect in patients with normal renal function.

After interaction with hydrochloric acid of gastric juice, aluminum hydroxide reacts with phosphates and carbonates in the alkaline environment of the intestine and is excreted with feces in the form of insoluble salts.
Magnesium hydroxide reacts with hydrochloric acid in gastric juice with the formation of magnesium chloride, which has an osmotic laxative effect in the small intestine. Magnesium is also excreted with feces in the form of insoluble carbonate.
INDICATIONS

- Heartburn (after taking medicines, alcohol, coffee, inaccuracies in feeding, abuse of nicotine, etc.);

- conditions accompanied by increased acid formation: gastritis, gastric ulcer and duodenal ulcer
intestines;
- symptomatic ulcers of different genesis;

- erosion of the gastric mucosa and upper gastrointestinal tract;

- reflux esophagitis;

- hernia of the esophageal aperture of the diaphragm;

- Acute pancreatitis, exacerbation of chronic pancreatitis (as part of combination therapy);

- Fermentation or putrefactive dyspepsia (as part of combination therapy).

DOSING MODE

Inside.
The tablet should be gradually dissolve (do not swallow whole).
Adults are recommended to take 1 hour after eating and before bedtime 1-2 tablets.
4-6 times / day, but not more than 8 tablets. within 24 hours.
The duration of Gastal should not exceed 2 weeks.

For prophylaxis, Gastal is used before the supposed irritant effect on the gastrointestinal mucosa.

Similar doses are recommended for heartburn, regardless of food intake.

For children aged 6-12 years , half the dose taken for adults is recommended.

SIDE EFFECT

Rarely : allergic reactions, nausea, vomiting, changes in taste, diarrhea, constipation.

CONTRAINDICATIONS

- chronic renal failure;

- Alzheimer's disease;

- hypophosphatemia;

- children's age till 6 years;

hypersensitivity.

With caution : children under 12 years;
during lactation and during pregnancy - only by appointment and under the supervision of a doctor.
PREGNANCY AND LACTATION

As with the appointment of all other drugs, the use of Gastal during pregnancy is possible only in special cases and only on the advice of a doctor.

APPLICATION FOR FUNCTIONS OF THE LIVER

Patients with impaired renal function are not recommended to use Gastal for longer and at higher doses than recommended.

APPLICATION FOR CHILDREN

With caution : children under 12 years.
Contraindication: children under 6 years.
SPECIAL INSTRUCTIONS

Patients with a small body weight and children are treated with lower doses and less durable.

Patients with impaired renal function are not recommended to use Gastal for longer and at higher doses than recommended.

Continuous reception for more than 2 weeks - only after consulting a doctor.

OVERDOSE

No symptoms of acute overdose.

With long-term use in high doses of drugs containing aluminum and magnesium, hypophosphatemia, hypocalcemia, hypercalciuria, osteomalacia, osteoporosis, hypermagnes and hyperaluminia, encephalopathy, nephrocalcinosis and renal dysfunction are possible.
Perhaps increased side effects from the digestive tract (constipation, diarrhea). In patients with concomitant renal failure - thirst, lowering blood pressure, hyporeflexia.
When these symptoms occur, symptomatic treatment should be performed.

DRUG INTERACTION

The interval between taking Gastal and other medications should be 1-2 hours.

Gastal enhances the activity of levodopa and nalidixic acid;
reduces and slows down the absorption of tetracycline antibiotics, ciproflocacin and ofloxacin, salicylates, isoniazid, naproxen, iron preparations, cardiac gipcosides, indomethacin, aminazine, phenytoin, H 2 -gistaminic receptor blockers, beta-address blockers, diflunizal, fat-soluble vitamins, indirect anticoagulants, barbiturates. M-holinoblokatory, slowing the emptying of the stomach, strengthen and lengthen the action of the drug.
TERMS OF RELEASE FROM PHARMACY

The drug is approved for use as a means of OTC.

TERMS AND CONDITIONS OF STORAGE

Store at a temperature not exceeding 25 ° C.
Shelf life - 3 years. Do not use after the expiration date.
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