Universal reference book for medicines
Product name: GALAVIT ® (GALAVIT)

Active substance: nonappropriate

Type: Immunostimulating drug

Manufacturer: SELVIM (Russia)
Composition, form of production and packaging

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Tablets are sublingual white with a yellowish tinge, biconvex, without risks, with a smell of menthol.
1 tab.

aminodihydrophthalazinedione sodium 25 mg

Excipients: sorbitol - 0.315 g, starch 0.14 g, lactose 0.1 g, calcium stearate 0.005 g, talc 0.015 g, racemenol (menthol) 0.0001 g.

10 pieces.
- packings of cellular contour (1) - packs cardboard.
10 pieces.
- packings cellular planimetric (2) - packs cardboard.
10 pieces.
- packings cellular planimetric (3) - packs cardboard.
10 pieces.
- packings cellular planimetric (4) - packs cardboard.
20 pcs.
- packings of cellular contour (1) - packs cardboard.
20 pcs.
- packings cellular planimetric (2) - packs cardboard.
20 pcs.
- packings cellular planimetric (3) - packs cardboard.
20 pcs.
- packings cellular planimetric (4) - packs cardboard.
INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2017.

PHARMACHOLOGIC EFFECT

The mechanism of action of Galavita is related to the ability to affect the functional metabolic activity of macrophages.

In inflammatory diseases, reversible (for 6-8 hours) inhibits excessive synthesis of tumor necrosis factor, interleukin-1 and other pro-inflammatory cytokines, active forms of oxygen by hyperactivated macrophages, determining the degree of inflammatory reactions, their cyclicity, and the severity of intoxication.
Normalization of the functional state of macrophages leads to the restoration of the antigen presenting and regulating function of macrophages, to a decrease in the level of autoaggression.
The drug stimulates the bactericidal activity of neutrophilic granulocytes, enhancing phagocytosis and increasing the nonspecific resistance of the organism to infectious diseases.

PHARMACOKINETICS

It is excreted from the body, mainly by the kidneys.
In the sublingual application, T 1/2 is 30 minutes.
The main pharmacological effects are observed for 72 hours.

INDICATIONS

As an immunomodulator and an anti-inflammatory drug in the complex therapy of immunodeficient conditions in adults and adolescents over 12 years of age:

- infectious intestinal diseases, accompanied by intoxication and / or diarrhea;

- Stomach ulcer and duodenal ulcer;

- viral hepatitis;

- chronic recurrent diseases caused by the herpes virus;

- diseases caused by the human papillomavirus;

- infectious and inflammatory diseases of the urogenital tract (urethritis of chlamydial and trichomonas etiology, chlamydial prostatitis, acute and chronic salpingoophoritis, endometritis);

- Pyoinflammatory diseases of the pelvic organs;

- postoperative rehabilitation of patients with uterine myoma;

- Complications of the postoperative period in patients of reproductive age;

- purulent surgical diseases (burn lesions, chronic osteomyelitis, gangrenous appendicitis with omentitis, peritonitis, purulent pleurisy);

- postoperative purulent-septic complications and their prevention (including in cancer patients);

- chronic recurrent furunculosis, erysipelas;

- asthenic conditions, neurotic and somatoform disorders, decrease in physical working capacity (including athletes);

- mental, behavioral and post-abstinence disorders in alcohol and drug dependence;

- inflammatory diseases of the mucous membrane of the oral cavity and throat, periodontal disease;

- frequent recurrent diseases of the respiratory tract and ENT organs of bacterial and viral etiology (including frequent acute respiratory viral infections, bronchitis, pneumonia, chronic tonsillitis, chronic otitis media, chronic adenoiditis) and their prophylaxis.

DOSING MODE

Sublingually 1 tab.
daily up to 4 times / day or 2 tab. daily up to 2 times / day, depending on the diagnosis and severity of the disease.
In acute infectious intestinal diseases, accompanied by diarrheal syndrome, the initial dose is 2 tab.
once, then - 1 tab. 3-4 times / day until relief of symptoms of intoxication within 3-5 days.
With gastric ulcer and duodenal ulcer in an acute period
at The first 2 days should be taken on 1 tab. 4 times / day, then - every 3 days for 1 tab. 4 times / day, the course is 2-3 weeks. In the chronic period take for 5 days to 1 tab. 4 times / day, then - every 3 days for 1 tab. 4 times / day course up to 3 weeks.
With viral hepatitis of different etiology
in the acute period of the disease, the initial dose is 2 tab. 2 times / day until the relief of symptoms of intoxication and inflammation. Perhaps the subsequent continuation of the course of 1 tab. 4 times / day every 3 days for up to 2-3 weeks.
When
chronic recurrent diseases caused by the herpes virus - 1 tab. 4 times / day for 10 days. Then - 1 tab. 4 times a day in a day for 10 days.
In diseases caused by the human papillomavirus, one should take 5 days for 1 tab.
4 times / day, then - 1 tab. 4 times a day every other day up to 2-3 weeks.
With urogenital diseases (urethritis chlamydial and trichomonas etiology, chlamydial prostatitis) on the first day of 2 tab.
2 times / day, then - 1 tab. 4 times / day through the day, up to 2 weeks (depending on the severity of the pathological process).
With salpingo-oophoritis, endometrium in acute period - 2 tab.
2 times / day for 2 days, then - 1 tab. 4 times / day every 3 days for 3 weeks. In the chronic period - within 5 days of 1 tab. 4 times / day, then - 1 tab. 4 times / day every 3 days for up to 2-3 weeks.
When
acute and chronic purulent diseases of the pelvic organs in the acute period on the first day of 2 tab. 2 times / day, then - 3 days to 1 tab. 4 times / day, then - 1 tab. 4 times / day every other day for 10 days. In the chronic period - within 5 days of 1 tab. 4 times / day, then - 3-4 tablets / day every 3 days for up to 3 weeks.
For
postoperative rehabilitation of patients with uterine myoma and with complications of the postoperative period in women of reproductive age, the drug should be taken within 5 days of 1 tab. 4 times / day, then - 1 tab. 4 times a day every other day up to 2 weeks.
When
purulent surgical diseases (burn lesions, chronic osteomyelitis, gangrenous appendicitis with omentitis, peritonitis, purulent pleurisy) apply 4 times / day for 1 tab. for 5 days, then - 1 tab. 4 times a day, up to 15 days.
For
prevention and treatment of surgical complications in the pre- and postoperative period (including cancer patients) appoint 1 tab. 4 times / day for 5 days before the operation, within 10 days after the operation, 1 tab. 4 times every other day and within 3 weeks of 1 tab. 4 times in 3 days. In severe disease - on the first day of 2 tab. 2 times / day.
With chronic recurrent furunculosis, erysipelas -
5 days to 1 tab. 4 times / day, then - 1 tab. 4 times a day, up to 3 weeks.
With asthenic conditions, neurotic and somatoform disorders, with mental, behavioral and post-abstinence disorders in patients with alcohol and drug dependence -5 days to 1 tab.
4 times / day, then - 1 tab. 4 times every 3 days for 3 weeks.
To increase physical performance - 1 tab.
4 times every other day for 10 days, then - 1 tab. 4 times / day in 3 days up to 3 weeks.
With inflammatory diseases of the mucous membrane of the oral cavity and throat, periodontal diseases, the initial dose of 1 tab.
4 times / day for 5 days, then - 1 tab.4 times / day in 3 days up to 3 weeks.
With frequent recurrent diseases of the respiratory tract and ENT organs of bacterial and viral etiology (frequent acute respiratory infections, bronchitis, pneumonia, chronic tonsillitis, chronic otitis media, chronic adenoiditis) apply 4 times / day for 1 tab.
for 5 days, then - 1 tab. 4 times a day, up to 15 days.
For the prevention of acute respiratory infections and influenza - 1 tab.
2 times / day. Course 5-10 days.
SIDE EFFECT

Rarely: allergic reactions are possible.

CONTRAINDICATIONS

- Pregnancy;

- lactation period;

- Individual intolerance.

PREGNANCY AND LACTATION

The use of the drug is contraindicated in pregnancy and lactation.

APPLICATION FOR CHILDREN

The drug is intended for use in adults and adolescents over 12 years.

SPECIAL INSTRUCTIONS

When used simultaneously with the drug Galavit ®, the possible reduction in the dose of antibiotics.

OVERDOSE

Data on overdose are absent.

DRUG INTERACTION

Cases of incompatibility with other drugs have not been noted.

TERMS OF RELEASE FROM PHARMACY

The drug is approved for use as a means of OTC.

TERMS AND CONDITIONS OF STORAGE

The drug should be stored out of reach of children, protected from light at a temperature of no higher than 25 ° C.
Shelf life - 3 years.
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