Universal reference book for medicines
Product name: VALEODICRAMEN (VALEODICRAMEN)

Active substance: comb.
drug
Type: Phytomedication with sedative effect

Manufacturer: ВОРОНЕЖФАРМАЦИЯ ГУП ВО (Russia)
Composition, form of production and packaging
Drops for oral administration
50 ml

tincture of valerian 16.6 ml

tincture of the herb of the motherwort 16.6 ml

tincture of hawthorn fruit 8.4 ml

tincture of peppermint leaves 8.4 ml

Diphenhydramine 50 mg

25 ml - a vial of a dropper (1) - packs cardboard.

25 ml - bottles (1) - packs of cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2011.

PHARMACHOLOGIC EFFECT

The combined preparation has sedative as well as spasmolytic effect.
Pharmacological activity is due to its constituent components of plant origin and diphenhydramine.
Hawthorn tincture has a moderate cardiac, spasmolytic, sedative effect.

Valerian tincture due to the ester borneol and isovaleric acid and free valerian acid has a moderately expressed sedative and spasmolytic (with respect to smooth muscles of the gastrointestinal tract) action.
Facilitates the onset of natural sleep. Sedation is slow, but fairly stable. It also has a cholagogue effect, increases the secretion of the glands of the gastrointestinal tract.
Mint pepper tincture has a moderate spasmolytic effect on the organs of the gastrointestinal tract and a mild sedative effect, has choleretic properties.

Motherwort tincture has a sedative, mild cardiotonic (slows the rhythm and increases the strength of the heartbeat), has moderate hypotensive properties.

Diphenhydramine - the blocker of H1-histamine receptors of the first generation, has anti-allergic, sedative and hypnotic effects.
Influence on the central nervous system is due to blockade of H3-histamine receptors in the brain and inhibition of cholinergic structures.
PHARMACOKINETICS

The effect of the drug is the combined effect of its components, therefore it is not possible to carry out pharmacokinetic studies.

INDICATIONS

As a sedative for neuroses, vegetative-vascular dystonia with a tendency to increase blood pressure and palpitation.

DOSING MODE

Inside adults, 30-40 drops, previously diluted in a small amount of water, 3-4 times a day, 30 minutes before eating.
The course of treatment is 10-15 days. Conducting repeated courses of treatment is possible on the recommendation of a doctor, but not earlier than in 1-1.5 months.
SIDE EFFECT

Allergic reactions, rarely - dyspepsia, with prolonged use - dryness of the oral mucosa.

If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, tell your doctor.

CONTRAINDICATIONS

Hypersensitivity to the components of the drug, a tendency to arterial hypotension, acute and chronic heart failure, a decrease in the heart rate (less than 55 beats per minute), epilepsy, alcoholism, traumatic brain injury, brain diseases, kidney and / or liver dysfunction, age to 18 years (efficacy and safety of admission not established).

PREGNANCY AND LACTATION

Special clinical studies on the use of the drug during pregnancy and during breastfeeding have not been carried out, so its use in the above conditions is not recommended.

APPLICATION FOR FUNCTIONS OF THE LIVER

Contraindicated: impaired renal function.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS

Contraindicated: liver dysfunction.

APPLICATION FOR CHILDREN

Contraindicated: age under 18 years (efficacy and safety of admission not established).

SPECIAL INSTRUCTIONS

During the treatment period, it is necessary to refrain from driving vehicles and practicing potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.
The content of ethyl alcohol in the preparation is not less than 67%.
The absolute ethyl alcohol content in a single dose (30-40 drops) from 0.72 to 0.96 g, and in the maximum daily dose (160 drops) - 3.84 g.

OVERDOSE

Symptoms: depression or excitation (especially in children with random admission) of the central nervous system, depression, pupil dilated, dry mouth, slowing down the motility of the gastrointestinal tract.

Treatment: there is no specific antidote.
Gastric lavage. Supportive measures include monitoring blood pressure, if necessary - drugs that increase blood pressure, oxygen, the introduction of plasma-replacing fluids intravenously. You can not use epinephrine (Adrenaline) and analeptics.
DRUG INTERACTION

With simultaneous administration with drugs that depress the central nervous system (sedatives, hypnotics, tranquilizers, antipsychotics), mutual enhancement of effects is possible.
Inhibitors of monoamine oxidase (MAO) increase the anticholinergic activity of diphenhydramine.
TERMS OF RELEASE FROM PHARMACY

The drug is released by prescription.

TERMS AND CONDITIONS OF STORAGE

In the dark place at a temperature of 15 to 25 ° C.
Keep out of the reach of children.
Shelf life.
3 years. Do not use after expiry date.
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