Universal reference book for medicines
Product name: VAZOMAG (VAZOMAG)

Active substance: meldonium

Type: A drug that improves the metabolism and energy supply of tissues

Manufacturer: OLAINFARM (Latvia)
Composition, form of production and packaging
Capsules
hard gelatinous, size 1, white / white;
the contents of the capsules are white or almost white powder.
1 caps.

meldonium dihydrate 250 mg

Auxiliary substances: potato starch - 18.125 mg, silicon dioxide colloid - 5.5 mg, calcium stearate - 1.375 mg.

The composition of the capsule shell: titanium dioxide (E171) - 2%, gelatin - up to 110%.

10 pieces.
- packings cellular planimetric (2) - packs cardboard.
10 pieces.
- packings cellular planimetric (4) - packs cardboard.
INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2014.

PHARMACHOLOGIC EFFECT

A drug that improves the metabolism and energy supply of tissues.
Meldonium is an analogue of gamma-butyrobetaine, it suppresses gamma-butyrobetaine hydroxynase, reduces the synthesis of carnitine and transport of long chain fatty acids through cell membranes, prevents the accumulation of activated forms of unoxidized fatty acids - acylcarnitine and acylcoenzyme A cells - in cells. Under conditions of ischemia, it restores the equilibrium of oxygen delivery processes and its consumption in cells, prevents disruption of transport of adenosine triphosphate; simultaneously, it activates glycolysis, which proceeds without additional consumption of oxygen. As a result of a decrease in the concentration of carnitine, the synthesis of gamma-butyrobetaine is enhanced, which has vasodilating properties.
The mechanism of action determines the variety of pharmacological effects of meldonia: increasing efficiency, reducing the symptoms of mental and physical overstrain, the activation of tissue and humoral immunity, cardioprotective action.
In the case of acute ischemic damage, the myocardium slows the formation of the necrotic zone, shortens the rehabilitation period. With heart failure increases myocardial contractility, increases exercise tolerance, reduces the incidence of angina attacks. In acute and chronic ischemic disorders of cerebral circulation improves blood circulation in the ischemic focus, promotes redistribution of blood in favor of the ischemic site. Effective in the case of vascular and dystrophic pathology of the fundus. It is also characteristic of a tonic effect on the central nervous system, the elimination of functional disorders of somatic and autonomic nervous systems in patients with chronic alcoholism during the period of abstinence.
PHARMACOKINETICS

Suction

After oral intake quickly absorbed, bioavailability - 78%.
C max in blood plasma is achieved 1-2 hours after ingestion.
Metabolism and excretion

Metabolized in the body with the formation of two major metabolites, which are excreted by the kidneys.
T 1/2 for oral administration depends on the dose and is 3-6 hours.
INDICATIONS

- in neurology in complex therapy: ischemic stroke, hemorrhagic stroke in the recovery period, transient cerebral circulation disorders, chronic cerebral circulatory insufficiency;

- in cardiology in complex therapy: IHD (angina pectoris, myocardial infarction), chronic heart failure, dyshormonal cardiomyopathy;

- reduced working capacity;

- physical overvoltage, incl.
athletes;
- Postoperative period to accelerate rehabilitation;

- withdrawal alcohol syndrome (in combination with specific therapy).

DOSING MODE

The drug is prescribed inside.

When cerebral circulation is disturbed in the acute phase, the injection form of the drug is used for 10 days, after which the drug is administered orally at 500 mg / day.
The course of treatment is 4-6 weeks.
With chronic disorders of the cerebral circulation - 500 mg 1 time / day, preferably in the morning.
The course of treatment is 4-6 weeks. Repeated courses - 2-3 times a year.
In cardiology in the complex therapy - 0.5-1 g / day.
The course of treatment is 4-6 weeks.
With cardialgia against the background of dyshormonal myocardial dystrophy - 250 mg 2 times / day (morning and evening).
The course of treatment is 12 days.
At mental and physical overloads (including at sportsmen) adults - on 250 mg 4 times / sut.
The course of treatment is 10-14 days. If necessary, the treatment is repeated after 2-3 weeks.
Before training - for 0.5-1 g 2 times / day, preferably in the morning.
The duration of the course in the preparatory period is 14-21 days, during the competition - 10-14 days.
With abstinence alcohol syndrome - 500 mg 4 times / day.
The course of treatment is 7-10 days.
SIDE EFFECT

Rarely: allergic reactions (skin itching, rashes, redness and swelling of the face), dyspepsia, tachycardia, agitation, lowering blood pressure.

CONTRAINDICATIONS

- Increase in intracranial pressure (with violation of venous outflow and intracranial tumors);

- Pregnancy;

- lactation period (breastfeeding);

- children's age till 18 years;

- Hypersensitivity to the components of the drug.

With caution should apply the drug in diseases of the liver and / or kidney.

PREGNANCY AND LACTATION

The drug is contraindicated in pregnancy and during breastfeeding.

APPLICATION FOR FUNCTIONS OF THE LIVER

With caution appoint a drug for kidney disease.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS

With caution appoint a drug for liver diseases.

APPLICATION FOR CHILDREN

The drug is contraindicated in children under 18 years.

SPECIAL INSTRUCTIONS

Impact on the ability to drive vehicles and manage mechanisms

There are no data on the adverse effect of the drug on the ability to drive vehicles.

OVERDOSE

Cases of an overdose of Vasomag are not established.

DRUG INTERACTION

Do not apply simultaneously with other medicinal forms containing meldonium (risk of side effects).

Strengthens the coronarodilating and some antihypertensive agents, cardiac glycosides.

In view of the possible development of moderate tachycardia and arterial hypotension, caution should be exercised when combined with nitroglycerin, nifedipine, alpha-adrenoblockers, antihypertensive agents and peripheral vasodilators.

You can combine with antianginal drugs, anticoagulants, antiaggregants, antiarrhythmics, diuretics, bronchodilators.

TERMS OF RELEASE FROM PHARMACY

The drug is released by prescription.

TERMS AND CONDITIONS OF STORAGE

List B. The drug should be stored out of reach of children, dry place at a temperature of no higher than 25 ° C.
Shelf life - 2 years.
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