Universal reference book for medicines
Product name: VAZOKET ® (VASOKET ® )

Active substance: diosmin

Type: Venotonizing drug

Manufacturer: STRAGEN PHARMA (Switzerland) manufactured by WEIMER PHARMA (Germany)
Composition, form of production and packaging
Tablets are
oblong, from grayish-yellow to light-yellow color with a fault line from both sides.

1 tab.

diosmin 600 mg

Excipients: corn starch, magnesium stearate, povidone, microcrystalline cellulose.

15 pcs.
- blisters (1) - packs of cardboard.
15 pcs.
- blisters (2) - packs of cardboard.
INSTRUCTION FOR THE SPECIALIST.

The product description was approved by the manufacturer for the 2009 print edition.

PHARMACHOLOGIC EFFECT

Diosmin has a venotonic effect (reduces vein dilatation), increases venous tone (dose-dependent effect), reduces venous congestion, improves lymphatic drainage (increases the tone and frequency of lymphatic capillary contraction, increases their functional density, reduces lymphatic pressure), improves microcirculation (increases resistance of capillaries (dose-dependent effect), reduces their permeability), reduces the adhesion of leukocytes to the venous wall and their migration to parainous tissues, improves diffusion of oxygen and
erfuziyu in dermal tissue, it possesses anti-inflammatory action. Strengthens the vasoconstrictive effect of adrenaline, norepinephrine, serotonin, blocks the production of free radicals, the synthesis of prostaglandins and thromboxane.
PHARMACOKINETICS

Suction

After ingestion, the drug is rapidly absorbed from the digestive tract and is determined in the blood plasma after 2 hours. C max in the blood plasma is reached 5 hours after ingestion.

Distribution

Evenly distributed and accumulated in all layers of the wall are hollow veins and subcutaneous veins of the lower limbs, to a lesser extent - in the kidneys, liver, lungs and other organs.
The selective accumulation of diosmin and / or its metabolites in venous vessels reaches a maximum of 9 hours after administration and is maintained for 96 hours.
Excretion

It is excreted in urine 79%, with feces - 11%, with bile - 2.4%.

INDICATIONS

- Varicose veins;

- chronic lympho-venous insufficiency of the lower extremities;

- exacerbation of hemorrhoids;

- disorders of microcirculation.

DOSING MODE

With varicose veins of the lower extremities and in the initial stage of chronic lympho-venous insufficiency (heaviness in the legs), 1 tablet / day is prescribed in the morning before breakfast for 2 months, with severe forms of chronic lympho- venous insufficiency (edema, pain, convulsions) treatment continues for 3-4 months, with trophic changes and ulcers, treatment is extended to 6 months or more.
The course is repeated after 2-3 months.
With an exacerbation of hemorrhoids prescribe the drug for 2-3 tab. / Day during meals for 7 days, then, if necessary, you can continue to 1 tab.
1 time / day for 1-2 months.
In the treatment of chronic lympho-venous insufficiency in the II and III trimesters of pregnancy , 1 tablet is prescribed.
1 time / day and cancellation 2-3 weeks before delivery. In case of missing one or more doses, the drug should be continued in the usual dosage.
SIDE EFFECT

From the digestive system: rarely - dyspepsia.

From the side of the central nervous system: rarely -
headache.
CONTRAINDICATIONS

- age up to 18 years;

- Hypersensitivity to the components of the drug.

PREGNANCY AND LACTATION

So far, in clinical practice, there have been no reports of any side effects when the drug is used in pregnant women.

In experimental studies, there was no teratogenic effect on the fetus.

During breastfeeding, taking the drug is not recommended, because
there is no data on the penetration of the drug into breast milk.
APPLICATION FOR CHILDREN

Contraindication: age to 18 years.

SPECIAL INSTRUCTIONS

Treatment of an exacerbation of a hemorrhoids spend in a complex with other preparations, in the absence of a fast clinical effect it is necessary to spend additional inspection and to correct spent therapy.

There are data on the possible effectiveness of the drug in the treatment of fetoplacental insufficiency, for the prevention of bleeding that occurs with intrauterine devices and during phlebectomy.

OVERDOSE

Symptoms of overdose are not described.

DRUG INTERACTION

Clinically significant effects of interaction with other drugs are not described.

TERMS OF RELEASE FROM PHARMACY

The drug is released by prescription.

TERMS AND CONDITIONS OF STORAGE

The drug should be stored out of reach of children at a temperature of no higher than 30 ° C.
Shelf life - 3 years.
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