Universal reference book for medicines
Product name: BENZONAL

Active substance: benzobarbital

Type: Anticonvulsant drug

Manufacturer: АСФАРМА (Russia)
Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

PHARMACHOLOGIC EFFECT
Antiepileptic agent.
Practically does not have sleeping pills.
Strengthens inhibitory GABA-ergic effects on the central nervous system, especially in the thalamus, the ascending activating reticular formation of the brainstem at the level of intercalary neurons.
Reducing the permeability of nerve fiber membranes for sodium ions, reduces the spread of impulses from the focus of epileptic activity. The effect occurs after 20-60 minutes after oral administration.
PHARMACOKINETICS
Metabolized with the formation of phenobarbital, which has an antiepileptic effect.
Binding to blood plasma proteins is weak. High concentrations are found in the brain, liver and kidneys. Penetrates through the histogematic barriers, excreted in breast milk. T 1/2 is 3-4 days. It is excreted by the kidneys both in unchanged form and in the form of metabolites.
INDICATIONS
Epilepsy of various genesis, generalized and partial seizures.

DOSING MODE
Install individually.
Inside - for 100 mg 3 times / day. The maximum dose: single dose - 300 mg, daily - 800 mg. Treatment begins with a single dose of a single dose.After 2-3 days gradually increase the dose to achieve a clinical effect (reduced frequency or complete cessation of seizures). Treatment is long.
Children aged 3-6 years - 25-50 mg per day (100-150 mg / day), 7-10 years - 50-100 mg per reception (150-300 mg / day), 11-14 years - on 100 mg on reception (300-400 mg / sut).
The maximum dose for children (older age): single dose - 150 mg, daily - 450 mg.
SIDE EFFECT
From the side of the central nervous system: rarely - drowsiness, lethargy, inhibition, headache, ataxia, nystagmus, speech difficulties (in these cases, dose adjustment or caffeine administration is required).

From the hemopoietic system: thrombocytopenia, anemia.

From the cardiovascular system: a decrease in blood pressure, thrombophlebitis.

Other: impairment of appetite, allergic reactions, bronchospasm.

CONTRAINDICATIONS
Severe violations of kidney and / or liver function, chronic heart failure II-III stage, porphyria, anemia, bronchial asthma, respiratory failure, diabetes mellitus, adrenal insufficiency, hyperkinesia, depressive states (with suicidal attempts), hypersensitivity to benzobarbital.

APPLICATION FOR FUNCTIONS OF THE LIVER
Contraindicated in severe renal dysfunction.

APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
Contraindicated in severe violations of liver function.

SPECIAL INSTRUCTIONS
In patients who have previously taken barbiturates, when switching to benzobarbital treatment, sleep disturbances are possible.
In these cases, prescribe for the night phenobarbital (50-100 mg) or other sleeping pills.
DRUG INTERACTION
Strengthening the effects of opioid analgesics, anesthetics, antipsychotics, anxiolytics, tricyclic antidepressants, ethanol, hypnotics.

With simultaneous use, there is a decrease in the effectiveness of paracetamol, anticoagulants, tetracyclines, griseofulvin, GCS, mineralocorticoids, cardiac glycosides, quinidine, vitamin D, xanthines.

With simultaneous use with drugs that have a mielodepressivnoe effect, there is an increase in hematotoxicity.

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