Universal reference book for medicines
Product name: BENZYLPENICILLIN-CMS (BENZYLPENICILLIN-KMP)

Active substance: benzylpenicillin

Type: Antibiotic of the penicillin group, destroying penicillinase

Manufacturer: KIEVMEDPREPARAT (Ukraine)
Description of the active substance:
This information is a reference and it is not enough that the drug has been prescribed by a doctor ..

PHARMACHOLOGIC EFFECT
Antibiotic group of biosynthetic penicillins.
Has a bactericidal effect by inhibiting the synthesis of the cell wall of microorganisms.
It is active against Gram-positive bacteria: Staphylococcus spp., Streptococcus spp.
(including Streptococcus pneumoniae), Corynebacterium diphtheriae, Bacillus anthracis; Gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis; anaerobic spore-forming sticks; and also Actinomyces spp., Spirochaetaceae.
The strains of Staphylococcus spp., Which produce penicillinase, are resistant to the action of benzylpenicillin.
Destroyed in an acidic environment.
Novocain salt of benzylpenicillin in comparison with potassium and sodium salts is characterized by a longer duration of action.

PHARMACOKINETICS
After the / m introduction quickly absorbed from the injection site.
Widely distributed in tissues and body fluids. Benzylpenicillin penetrates well through the placental barrier, GEB in case of inflammation of the meninges.
T 1/2 - 30 min.
It is excreted in the urine.
INDICATIONS
Treatment of diseases caused by microorganisms sensitive to benzylpenicillin: croup and focal pneumonia, pleural empyema, sepsis, septicemia, pyemia, acute and subacute septic endocarditis, meningitis, acute and chronic osteomyelitis, urinary and biliary tract infections, tonsillitis, purulent infections of the skin, soft tissues and mucous membranes, erysipelas, diphtheria, scarlet fever, anthrax, actinomycosis, treatment of purulent-inflammatory diseases in obstetric-gynecological practice, ENT diseases, eye diseases, gonorrhea, blen
norea, syphilis.
DOSING MODE
Individual.
Enter in / m, in / in, s / k, endolyumbalno.
With the / m and / in the introduction of adults daily dose varies from 250 000 to 60 million units.
The daily dose for children under the age of 1 year is 50 000-100 000 units / kg, over 1 year - 50 000 units / kg; if necessary, the daily dose can be increased up to 200 000-300 000 units / kg, according to vital indications - up to 500 000 units / kg. Multiplicity of administration 4-6 times / day.
Endolumbally, depending on the disease and the severity of the flow, adults - 5000-10 000 units, children - 2000-5000 units.
The drug is diluted in sterile water for injection or in 0.9% solution of sodium chloride at a rate of 1 thousand AD / ml. Before injection (depending on the level of intracranial pressure), remove 5-10 ml of CSF and add it to the solution of the antibiotic in equal proportions.
P / k benzylpenicillin is used to cut infiltrates (100 000-200 000 units per 1 ml of 0.25% -0.5% solution of novocaine).

Benzylpenicillin potassium salt is used only in / m and s / k, in the same doses as benzylpenicillin sodium salt.

Benzylpenicillin novocaine salt is used only in / m.
The average therapeutic dose for adults: one-time - 300 000 units, daily - 600 000 units. Children under the age of 1 year - 50 000-100 000 units / kg / day, over 1 year - 50 000 units / kg / day. Multiplicity of administration 3-4 times / day.
The duration of treatment with benzylpenicillin, depending on the form and severity of the course of the disease, can range from 7-10 days to 2 months or more.

SIDE EFFECT
From the digestive system: diarrhea, nausea, vomiting.

Effects due to chemotherapeutic effects: candidiasis of the vagina, candidiasis of the oral cavity.

From the side of the central nervous system: when using benzylpenicillin in high doses, especially with endolumbal introduction, neurotoxic reactions may develop: nausea, vomiting, increased reflex excitability, symptoms of meningism, seizures, coma.

Allergic reactions: fever, urticaria, skin rash, rash on the mucous membranes, joint pain, eosinophilia, angioedema.
Cases of anaphylactic shock with a lethal outcome are described.
CONTRAINDICATIONS
Hypersensitivity to benzylpenicillin and other drugs from the group of penicillins and cephalosporins.
Endolumbal administration is contraindicated in patients with epilepsy.
PREGNANCY AND LACTATION
Use in pregnancy is possible only if the intended benefit of therapy for the mother exceeds the potential risk to the fetus.

If it is necessary to use during the lactation period, the question of stopping breastfeeding should be solved.

APPLICATION FOR FUNCTIONS OF THE LIVER
Use with caution in patients with impaired renal function.

SPECIAL INSTRUCTIONS
With caution apply in patients with impaired renal function, with heart failure, predisposition to allergic reactions (especially with drug allergies), with increased sensitivity to cephalosporins (due to the possibility of developing cross-allergies).

If after 3-5 days after the start of the application of the effect is not observed, you should proceed to use other antibiotics or combination therapy.

In connection with the possibility of developing fungal superinfection, it is advisable to prescribe antifungal drugs when treating benzylpenicillin.

It should be borne in mind that the use of benzylpenicillin in subtherapeutic doses or early termination of treatment often leads to the emergence of resistant strains of pathogens.

DRUG INTERACTION
Probenecid reduces the tubular secretion of benzylpenicillin, as a result of which the concentration of the latter in the blood plasma increases, the half-life increases.

When used simultaneously with antibiotics that have a bacteriostatic effect (tetracycline), the bactericidal action of benzylpenicillin decreases.

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