Universal reference book for medicines
Product name: BALIZ-2 (BALIZ-2)

Active substance: nonappropriate

Type: Antiseptic for external and local use

Manufacturer: БАЛИЗ ФАРМА (Russia)
Composition, form of production and packaging
Solution for oral, topical and topical administration
1 ml

5-hydroxy-gamma-pyran-2-carboxylic (comenic) acid 3.4 mg

400 ml - bottles (1) - packs of cardboard.

500 ml - bottles (1) - packs of cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2010.

PHARMACHOLOGIC EFFECT

Baliz-2 is obtained by microbiological synthesis, using a strain of bacteria Gluconobacter oxydans, the main source of which is glucose.
The drug has antibacterial activity against staphylococcus, to a lesser extent, Proteus, Pseudomonas aeruginosa.
Stimulates reparative processes in the wound, promotes the rejection of necrotic tissues and liquefaction of pus.

It has antioxidant properties, has a pronounced anti-inflammatory, regenerative effect and helps cicatrize ulcers.

PHARMACOKINETICS

Baliz-2 does not affect the acid-forming and secretory functions of the stomach, does not accumulate in the body.
Quickly and completely absorbed in the gastrointestinal tract. The onset of action after 15-20 minutes, the duration of action is about 4-6 hours. The half-life period is about 10-20 hours. On the fourth day after a single oral administration, it is almost completely eliminated from the body through the kidneys and through the intestine.
INDICATIONS

- Wounds fresh and infected, burns, bedsores, posttraumatic osteomyelitis, trophic ulcers of various etiologies, phlegmon, abscesses, furuncles, carbuncles;

- peritonitis, proctologic diseases, autotransplantation of tissues;

- Stomach ulcer and duodenal ulcer.

DOSING MODE

Locally (including intracavitary), externally

Treatment of wounds, burns.
Wound or burn surface treated with only a solution of Baliz-2, then superimposed on it a napkin, richly moistened with the drug for 30-40 minutes. On the purulent wound, during the first 2-3 days after treatment of the wound surface with Baliz-2, apply a gauze cloth moistened with the same preparation for 30-40 minutes, then apply the same napkin for 10-12 hours. Then the wound is loosely bandaged or use a mesh bandage. Duration of treatment 3-5 days (until complete recovery).
In the case of pain syndrome, a sterile cloth, moistened with a solution of procaine in a concentration of 20 mg / ml (2% solution), is applied to the wound for 10 minutes beforehand.
The drug is usually applied 1-2 times a day until complete healing.
In case of a deep wound, use a loose tamponade or turunda.
With penetrating wounds, the drug is used two or three times a day for 60 minutes. Baliz-2 is administered with a syringe or micro-irrigator.
Treatment of posttraumatic osteomyelitis.
Baliz-2 is injected into the fistula by a syringe for 20-30 minutes, then the contents of the canal are removed and the drug is again injected into the fistula until the next bandage is done daily. In the wound entry, so that it does not close, put a sterile rubber band. The treatment is continued until the wound is completely healed.
Application for dermal plastics.
The wound is preliminarily prepared for skin plasty: a sterile napkin is moistened with a drug and applied to the affected area for 30 minutes. For three days every day, 6 of these applications are carried out. Then a skin graft is applied to the wound. The consumption of Baliz-2 for every 100 cm 2 of the wound surface is up to 200 ml.
Treatment of proctologic diseases.
Purulent wound, fistula, the cavity is washed with Baliz-2 by means of drains, then a sterile cloth moistened with a drug is applied to the wound for 20 minutes and left until the next dressing. In case of extensive lesions, wipes moistened with a procaine solution at a concentration of 20 mg / ml for 10-20 minutes are preliminarily applied to the wound surface. Purulent cavities in the pelvic area are irrigated with Baliz-2 drip twice a day for 500 ml.
When treating hemorrhoids on the affected area, apply a gauze napkin, abundantly moistened with Baliz-2 for 30-40 minutes.
Apply Baliz-2 1-2 times a day until complete healing.
Treatment of peritonitis.
Baliz-2 is used in the complex therapy of peritonitis as a means for sanitizing the abdominal cavity. After removing the source of peritonitis, Baliz-2 is used in a volume of 2 to 6 liters with an exposure of 3-5 minutes for intraoperative sanation of the abdominal cavity. Intraoperative sanation in the above amounts can be fractional 1.0-1.5 liters to pure contents.
Depending on the prevalence of peritonitis, the use of the drug during ablation of the abdominal cavity can be either flowing or fractional.

When Baliz-2 is administered by flow lavage in a volume of 6-10 L, it is necessary to pre-administer the procaine solution at a concentration of 5 mg / ml (0.5% solution).
Four volumes of Balise-2 take one volume of procaine. Fractional method is carried out with the preliminary introduction of 20 ml of the procaine solution, followed by the introduction of 50-100 ml of Baliz-2. The duration of administration of Baliz-2 30-40 min twice a day for 2-3 days.
In order to prevent pain syndrome (shock), the procaine solution must be administered strictly 5 minutes before the introduction of Baliz-2.

When a pain syndrome associated with an acidic pH of Balise-2 occurs, it is necessary to increase the dose of procaine.
Baliz-2 is administered very slowly (see also "special instructions").
During treatment, necessary infusion and disintegration therapy, antibiotic therapy, cardiac glycosides and analgesics are performed according to indications.

Inside

Treatment of peptic ulcer of the stomach and duodenum.
Baliz-2 is prescribed for 30-50 ml three times a day for 20 minutes before a meal, washed down with a sip of water. In severe forms of peptic ulcer disease, persistent pain syndrome, an additional 50 ml of the drug is prescribed before bedtime. The course of treatment is 30 days or more according to the scheme: 15 days of application of Baliz-2, then break 3-5 days and again use for 15 days. If necessary, repeat the course.
In case of painful sensations after taking Baliz-2, the drug should be diluted 1: 1 with water and taken 4-5 times a day, with a total daily dose of 150 ml.

SIDE EFFECT

A short burning sensation in the wound, allergic reactions.

CONTRAINDICATIONS

- Children under 18 years of age (no clinical studies have been performed in children under 18 years old);

- Hypersensitivity to the drug.

APPLICATION FOR CHILDREN

Contraindicated in children under 18 years.

SPECIAL INSTRUCTIONS

To eliminate hypersensibility for a few minutes, a cloth moistened with a procaine solution at a concentration of 20 mg / ml is applied.

In the treatment of peritonitis, a solution of procaine in a concentration of 5 mg / ml is preset, strictly 5 minutes before the introduction of Baliz-2, in order to prevent pain syndrome (shock).
Baliz-2 is administered slowly.
OVERDOSE

There were no cases of drug overdose.

DRUG INTERACTION

When interacting with solutions of hydrogen peroxide or potassium permanganate, the drug is inactivated.

TERMS OF RELEASE FROM PHARMACY

On prescription.

TERMS AND CONDITIONS OF STORAGE

In the dark place at a temperature of no higher than + 15 ° C.
Do not freeze. Keep out of the r
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