Composition, form of production and packaging
? The tablets covered with a film cover of green color, round, biconcave.
1 tab.
metamizole sodium 200 mg
quinine hydrochloride 50 mg
Excipients: microcrystalline cellulose (Avicel PH101), sodium carboxymethyl starch (primogel), collidon-25 (povidone), talc, magnesium stearate.
Sheath composition: talc, titanium dioxide, eudragid L 12.5 P (methacrylic acid and methyl methacrylate copolymer), macrogol 400, glycerol, castor oil, pigment green pigment (dye quinoline yellow E104, blue patented V E131).
10 pieces. - blisters (2) - packs of cardboard.
INSTRUCTION FOR THE SPECIALIST.
The product description was approved by the manufacturer for the 2009 print edition.
PHARMACHOLOGIC EFFECT
Combined drug. Metamizole sodium is a derivative of pyrazolone and has analgesic, antipyretic and weak anti-inflammatory action, the mechanism of which is associated with inhibition of prostaglandin synthesis by inhibition of COX.
Quinine oppresses the center of thermoregulation, in high doses - the auditory and visual zones of the cerebral hemispheres. Also quinine inhibits the development of erythrocytic forms of schizonts and gamontes of malaria, suppressing DNA replication, has a locally irritating and local anesthetic effect.
Pharmacological action develops in 20-40 minutes after taking the drug and reaches a maximum after 2 hours.
PHARMACOKINETICS
Data on the pharmacokinetics of the Analgin-Quinine preparation are not available.
INDICATIONS
- pain syndrome of various etiology (including headache, neuralgia, arthralgia, myalgia, myositis, algodismenorea, postoperative pain);
- Renal and biliary colic (in combination with antispasmodics);
- feverish conditions with infectious and inflammatory diseases.
DOSING MODE
Adults and children over 14 years of age, the drug is prescribed for 1-2 tablets. 1-3 times / day depending on the clinical picture. Children aged 12-14 years - 1 tab.3 times / day.
Duration of taking the drug (without consulting a doctor) as an antipyretic agent - no more than 3 days, as an analgesic - no more than 5 days.
Tablets should be taken without chewing, after eating.
SIDE EFFECT
On the part of the digestive system: nausea, vomiting, pain and discomfort in the epigastric and abdominal region, diarrhea; rarely - ulceration of the mucous membrane of the gastrointestinal tract, bleeding from the gastrointestinal tract.
From the side of the central nervous system and peripheral nervous system: headache, dizziness, fast fatigue, insomnia, limb tremor.
On the part of the senses: tinnitus and hearing impairment, visual impairment (blurred vision, scotoma, photophobia, diplopia, decreased visual fields, impaired color vision).
From the cardiovascular system: stenocardia, a feeling of palpitations, fainting.
On the part of the hematopoiesis system: leukopenia, agranulocytosis, hypoprothrombinemia.
From the urinary system: a violation of the kidneys (including oliguria, anuria, proteinuria), water retention and electrolytes.
Allergic reactions: sometimes - itching, eczema, enanthema, urticaria, angioedema; rarely anaphylactic shock; in some cases - malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), bronchospastic syndrome.
Other: increased body temperature.
CONTRAINDICATIONS
severe hepatic impairment;
- severe renal dysfunction;
- bronchial asthma;
- asthma caused by the intake of salicylates or other NSAIDs;
- diseases accompanied by bronchospasm;
- hereditary hemolytic anemia caused by deficiency of glucose-6-phosphate dehydrogenase;
- oppression hemopoiesis (agranulocytosis, neutropenia, leukopenia);
- Myasthenia gravis;
- diseases of the middle and inner ear, hearing loss;
- optic neuritis;
- children's age till 12 years;
- Hypersensitivity to the components of the drug, as well as to other pyrazolone derivatives.
With caution should prescribe the drug with increased sensitivity to other NSAIDs, with food, medicinal or other forms of allergy (including pollinosis, bronchial asthma), granulocytopenia (requires control of hematological indicators.)
PREGNANCY AND LACTATION
The drug is contraindicated in pregnancy and lactation (breastfeeding).
If necessary, the appointment in the lactation period should resolve the issue of stopping breastfeeding.
APPLICATION FOR FUNCTIONS OF THE LIVER
Caution should be given to patients with impaired renal function. Contraindicated in severe impairment of kidney function.
APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
With caution should prescribe the drug to patients with impaired liver function. Contraindicated in severe violations of liver function.
APPLICATION FOR CHILDREN
Contraindication: children under 12 years.
SPECIAL INSTRUCTIONS
Against the background of the drug should not use radiocontrast agents, colloidal blood substitutes and penicillin.
For prolonged (more than 7 days) use of the drug, control of the peripheral blood pattern is necessary.
Do not use the drug for acute pain in the abdomen (until finding out the cause).
In case of side effects (including those not mentioned above), the patient should stop taking the drug and consult a doctor.
Analgin-Quinine can be used simultaneously with antibiotics, chemotherapeutic agents and vitamins.
Patients suffering from bronchial asthma and hay fever may develop sensitivity reactions.
Impact on the ability to drive vehicles and manage mechanisms
In the period of taking the drug should not be engaged in driving vehicles and work with mechanisms, tk. there is a risk of a decrease in the ability to concentrate attention and speed of psychomotor reactions.
OVERDOSE
Symptoms: nausea, vomiting (including bloody), melena, epigastric pain, agranulocytosis, aplastic anemia, hemorrhagic diathesis, dizziness, tinnitus, clonic and tonic convulsions, cardiotoxic effect, skin rash (bullous, petechial, bark - or typhoid-like), anaphylactic shock, coma is possible.
Treatment: gastric lavage, administration of laxatives and gastroprotective drugs, forced diuresis, respiratory recovery, anti-shock measures, recovery of BCC; if necessary - symptomatic therapy, with the development of seizures - in / in barbiturates and diazepam. There is no specific antidote.
DRUG INTERACTION
The simultaneous use of metamizole sodium with other analgesics-antipyretics may lead to a mutual enhancement of toxic effects.
Tricyclic antidepressants, oral contraceptives, allopurinol disrupt the metabolism of metamizole sodium in the liver and increase its toxicity.
Barbiturates and phenylbutazone weaken the action of metamizole sodium.
Sedatives and tranquilizers increase the analgesic effect of metamizole sodium.
Metamizole sodium enhances the effect of ethanol-containing beverages.
Metamizole sodium, displacing from the bond with protein oral hypoglycemic drugs, indirect anticoagulants, GCS and indomethacin, enhances their effect.
Quinine can potentiate the action of drugs that block neuromuscular transmission.
Quinine increases the concentration of digoxin in the blood plasma and enhances its action.
Cimetidine reduces clearance and increases T 1/2 quinine.
Simultaneous use of Analgin-Quinine with cyclosporine reduces the level of the latter in the blood.
Inductors of microsomal oxidation accelerate metabolism and reduce the effectiveness of the drug; inhibitors of microsomal oxidation increase the effectiveness and risk of side effects.
With simultaneous use with thiamazole and sarcolysin, the risk of developing leukopenia increases.
Codeine, propranolol increase the action of Analgin-Quinine.
TERMS OF RELEASE FROM PHARMACY
The drug is approved for use as a means of OTC.
TERMS AND CONDITIONS OF STORAGE
The drug should be stored out of reach of children, dry, protected from light at a temperature of no higher than 25 ° C. Shelf life - 5 years.
