Description of the active substance :.
This information is a reference and it is not enough that the drug was prescribed by a doctor. .
PHARMACHOLOGIC EFFECT
A remedy for acne treatment. Has antimicrobial activity against Propionibacterium acne and Staphylococcus epidermidis. Along with this, it reduces the content of free fatty acids in the lipids of the skin, and also normalizes the broken processes of keratinization in the follicles of the sebaceous glands.
PHARMACOKINETICS
After application to the skin, azelaic acid penetrates the epidermis and dermis. Part of the absorbed azelaic acid is excreted by the kidneys unchanged, and the part in the form of dicarboxylic acids (C5, C7), formed from azelaic acid as a result of beta oxidation.
INDICATIONS
Acne vulgaris, seborrheic dermatitis, pathological hyperpigmentation (including melasma).
DOSING MODE
The dose and duration of treatment are set individually.
SIDE EFFECT
Local reactions: rarely (mainly at the beginning of therapy) - skin irritation, erythema, burning sensation, itching, peeling (pass on their own during further treatment).
CONTRAINDICATIONS
Hypersensitivity to azelaic acid.
PREGNANCY AND LACTATION
Possible use in pregnancy according to indications.
Given the low systemic bioavailability and low toxicity of azelaic acid, it is possible to use during lactation (breastfeeding).
In experimental studies on laboratory animals, the negative effect of azelaic acid on reproductive function was not revealed, and embryotoxic and teratogenic effects were not established.
SPECIAL INSTRUCTIONS
Avoid contact with mucous membranes and eyes.
