Universal reference book for medicines
Product name: AZELIK ® (AZELIC)

Active substance: azelaic acid
Type: Acne and hyperpigmentation medication
Manufacturer: Chemical-Pharmaceutical Plant Akrihin (Russia)
Composition, form of production and packaging
? Gel for external use 15% white or almost white, a slight specific odor is allowed.
100 g
azelaic acid 15 g
Auxiliary substances: benzoic acid 0.1 g, methylpyrrolidone 4 g, squalane 1 g, propylene glycol 8 g, disodium edetate 0.1 g, sodium hydroxide 0.25 g, dimethicone 1 g, macrogol cetostearate 1.4 g, carbomer interpolymer - 1.4 g, purified water - up to 100 g.
5 g - aluminum tubes (1) - cardboard packs.
30 g - aluminum tubes (1) - cardboard packs.
INSTRUCTION FOR THE SPECIALIST.
Description of the drug approved by the manufacturer for the printed edition of 2016.
PHARMACHOLOGIC EFFECT
The drug is for external use. Has bacteriostatic activity against Propionibacterium acne and Staphylococcus epidermidis, reduces the production of fatty acids that promote the occurrence of acne. Reduces the formation of comedones. By influencing the process of keratinization of epidermal cells, it suppresses the growth and activity of abnormal melanocytes, which cause hyperpigmentation of the melasma type. Has anti-acne, depigmenting effect.
PHARMACOKINETICS
Suction
After application on the skin penetrates the epidermis and dermis, 3.6% of the total dose is absorbed into the systemic bloodstream.
Metabolism and excretion
Part of the absorbed acid is excreted by the kidneys unchanged, part - in the form of dicarboxylic acids (C7, C5), formed as a result of beta-oxidation.
INDICATIONS
- acne vulgaris (acne vulgaris);
rosacea.
DOSING MODE
Apply externally.
The gel should be applied to previously thoroughly washed (water or cleansed with a mild cleansing cosmetic) and dried skin. The gel is applied a thin layer on the affected skin 2 times / day (morning and evening) and lightly rubbed. Approximately 2.5 cm of gel is sufficient for the entire surface of the face.
In patients with acne vulgaris (acne vulgaris), a marked improvement is usually observed after 4 weeks. For best results, the drug should be continued for several months.
SIDE EFFECT
From the skin and subcutaneous fat: at the beginning of treatment, there may be local irritating effect, flushing and flaking of the skin, burning, erythema, itching, usually stopping during treatment; possibly - skin allergic reactions.
CONTRAINDICATIONS
- Hypersensitivity to the components of the drug.
Caution should be used during pregnancy and lactation (breastfeeding).
PREGNANCY AND LACTATION
During pregnancy and during breastfeeding, they are used only if the intended benefit of therapy for the mother exceeds the risk to the fetus or infant.
SPECIAL INSTRUCTIONS
In cases of severe irritation of the skin in the first weeks of treatment, the gel can be applied 1 time / day; also a short-term cancellation of the drug is possible. After the disappearance of symptoms of skin irritation, you should resume regular use of the drug at the recommended dose.
Avoid getting the product into the eyes, as well as on the mucous membranes of the nose, lips and mouth, in case of accidental contact - immediately rinse with water.
During treatment it is necessary to protect the skin from the entire spectrum of solar radiation.
OVERDOSE
Currently, cases of drug overdose have not been described.
DRUG INTERACTION
It can be used in combination with other drugs for the therapy of acne.
TERMS OF RELEASE FROM PHARMACY
The drug is approved for use as a means of OTC.
TERMS AND CONDITIONS OF STORAGE
The drug should be stored out of the reach of children at a temperature of no higher than 25 ° C. Do not freeze. Shelf life - 2 years.
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