Universal reference book for medicines
Name of the drug: ADJIFLUX (AGIFLUX)

Active substance: algeldrate, magnesium hydroxide

Type: Antacid preparation

Manufacturer: AGIO PHARMACEUTICALS (India)
TFCS.
This information is a reference and it is not enough that the drug was prescribed by a doctor.
.
PHARMACHOLOGIC EFFECT
Combined product, the effect of which is due to its constituent components: antacid, adsorbing, enveloping, carminative and choleretic effect.
The relaxing effect of magnesium hydroxide balances the effect of algeldrat, which has an inverse effect on intestinal motility. Neutralizes free hydrochloric acid in the stomach, reduces the activity of gastric juice. The time in the stomach is about 1 hour.
PHARMACOKINETICS
Absorption is low.

INDICATIONS
acute gastritis;

- Hyperacid gastritis;

acute duodenitis;

- Stomach ulcer and duodenal ulcer (in the phase of exacerbation);

- symptomatic ulcers of different genesis;

- erosion of the mucous membrane of the upper gastrointestinal tract;

- reflux esophagitis;

- hernia of the esophageal aperture of the diaphragm;

acute pancreatitis;

- exacerbation of chronic pancreatitis;

- Hyperphosphatemia;

- Discomfort, gastralgia, heartburn (after excess consumption of ethanol, nicotine, coffee, medication, inaccuracies in the diet).

- Fermentation or putrefactive dyspepsia (as part of combination therapy).

DOSING MODE
Inside, 5-10 ml (suspension, gel) or 2-3 tablets.
1-2 hours after meals and at night, with peptic ulcer of the stomach - 30 minutes before meals; if necessary, single dose is increased to 15 ml or 3-4 tab. After achieving therapeutic effect - maintenance therapy of 5 ml or 1 tab. 3 times / day. within 2-3 months.
Children from 4 to 12 months - 7.5 ml (1/2 tsp), children over 1 year - 15 ml (1 tsp) 3 times / day.

For prophylaxis take 5-10 ml (suspension, gel) or 1-2 tablets.
before a possible irritant effect on the gastrointestinal mucosa.
To increase the effectiveness of the tablet should be chewed or kept in the mouth until completely dissolved.
Suspension or gel before the reception must be homogenized by shaking the bottle or carefully stretching the packet between the fingers. The contents of the package are squeezed into a spoon or into the mouth.
SIDE EFFECT
Nausea, vomiting, changes in taste, constipation.

With long-term admission in high doses - hypophosphatemia, hypocalcemia, hypercalciuria, osteomalacia, osteoporosis, hypermagnesia, hyperaluminia, encephalopathy, nephrocalcinosis, renal dysfunction.

In patients with concomitant renal failure - thirst, lowering blood pressure, hyporeflexia.

CONTRAINDICATIONS
hypersensitivity;

- CRF;

- Pregnancy;

- Alzheimer's disease;

hypophosphatemia.

With caution: children's age (up to 12 years), lactation.

PREGNANCY AND LACTATION
Contraindicated in pregnancy, use with caution - during lactation.

APPLICATION FOR FUNCTIONS OF THE LIVER
Contraindicated in chronic renal failure.

APPLICATION FOR CHILDREN
Use with caution in children under 12 years of age.

SPECIAL INSTRUCTIONS
For long-term administration, sufficient supply of phosphorus salts should be provided with food.

For an adequate selection of a single dose, it is advisable to conduct an acute pharmacological test (after the suspension is inserted through the stomach probe and then washed with 10 ml of water, the pH of the gastric juice is evaluated after 1 h, and if the pH is below 3.5, an increase in the dose is necessary).

DRUG INTERACTION
Reduces and slows down the absorption of digoxin, indomethacin, salicylates, chlorpromazine, phenytoin, H 2 -gistamine receptor blockers, beta-adrenoblockers, diflunizal, ketoconazole and itraconazole, isoniazid, tetracycline antibiotics and quinolones (ciprofloxacin, norfloxacin, ofloxacin, enoxacin, gropofloxacin and others. .), azithromycin, cefpodoxim, pivampicillin, rifampicin, indirect anticoagulants, barbiturates (they should be used 1 hour before or 2 hours after taking antacids), fexofenadine, dipyridamole, zalcite
ins, chenodeoxycholic and ursodeoxycholic acid, penicillamine and lansoprazole.
M-holinoblokatory, slowing the emptying of the stomach, strengthen and lengthen the action of the drug.


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