Universal reference book for medicines
Product name: ADGELON ® (ADGELON)

Active substance: nonappropriate

Type: A drug that stimulates regeneration processes for topical application in ophthalmology

Manufacturer: ЭНДО-ФАРМ-А ПП (Russia)
Composition, form of production and packaging
Eye drops
in the form of a transparent, colorless liquid.

1 ml

Adegelone (0.01% glycoprotein solution in water for injection) 10 -9 ml

Excipients: sodium chloride, calcium chloride, water d / and.

1.5 ml - a tube-dropper (1) - packs cardboard.

5 ml - a tube-dropper (1) - packs cardboard.

5 ml - bottles (1) - packs cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2015.

PHARMACHOLOGIC EFFECT

A drug that stimulates regeneration processes for topical application in ophthalmology.
The active substance of the preparation is a glycoprotein, isolated from blood serum of cattle.
Adelon ® stimulates reparative processes in the cornea of ​​the eye, promoting the activation of fibroblastic elements, prevents the development of the inflammatory process, the proliferation of scar tissue, the growth of blood vessels in the cornea.

The pharmacological action of Adgelon ® is due to its ability to modulate the adhesion interactions of cells of mesenchymal origin, as well as its ability to inhibit the processes of lipid peroxidation, which can be considered as a universal mechanism of damage to cell membrane structures under various pathological conditions, the action of extreme factors, and aging.

In the case of burn damage to the eyes, the therapeutic effect of Adegelon is noted by the 14th day and is accompanied by a significant proliferation of fibroblastic elements infiltrating the injured corneal tissue, while the vector orientation of the proliferating cells imitates the original morphological structure of the cornea.

The drug is non-toxic, does not adversely affect the eye tissues and the body as a whole, does not cause an allergic reaction of the tissue with prolonged use.

PHARMACOKINETICS

Data on the pharmacokinetics of the drug Adgelon ® are not provided.

INDICATIONS

- keratopathy;

- corneal erosion;

- keratitis (including herpetic and adenoviral);

- eye burns;

penetrating wounds of the cornea.

DOSING MODE

Drops are instilled in the lower conjunctival sac of the affected eye 1-2 drops 3-6 times / day for at least 14 days.
In severe cases , during the first 3-7 days, the drug is instilled every 2 hours.
SIDE EFFECT

Possible: allergic reactions.

CONTRAINDICATIONS

- Individual hypersensitivity to one of the components of the drug.

PREGNANCY AND LACTATION

Data on the use of the drug Adgeelon ® during pregnancy and lactation (breastfeeding) no.

SPECIAL INSTRUCTIONS

Perhaps the simultaneous use of Adegelon with other ophthalmic drugs, disinfecting drops and solutions of antibiotics.
When complex therapy is recommended compliance with the time interval (15-30 min) between the instillations of drugs.
Before using Adgeleon ® , contact lenses should be removed and re-installed 15 minutes after instillation.

OVERDOSE

Due to the low concentration of the drug and its insignificant absorption, the possibility of an overdose is unlikely.

DRUG INTERACTION

Drug interaction of the drug Adgeelon ® with other drugs is not described.

TERMS OF RELEASE FROM PHARMACY

The drug is released by prescription.

TERMS AND CONDITIONS OF STORAGE

The drug should be stored in a dry, protected from light, out of reach of children at a temperature of 4 ° to 20 ° C.
Shelf life - 2 years. After opening the vial the drug can be stored at a temperature of 4 ° to 10 ° C for no more than 2 days.

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