Universal reference book for medicines
Product name: ADVIL FOR CHILDREN (ADVIL FOR CHILDREN)

Active substance: ibuprofen

Type: NSAIDs

Manufacturer: PFIZER CORPORATION AUSTRIA (Austria) manufactured by FAMAR LYON (France)
Description of the active substance :.
This information is a reference and it is not enough that the drug was prescribed by a doctor.
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PHARMACHOLOGIC EFFECT
NSAID, a derivative of phenylpropionic acid.
Has anti-inflammatory, analgesic and antipyretic effect.
The mechanism of action is associated with oppression of the activity of COX, the main enzyme of arachidonic acid metabolism, which is the precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever.
The analgesic effect is caused both by peripheral (indirectly, through suppression of prostaglandin synthesis) and by the central mechanism (inhibition of prostaglandin synthesis in the central and peripheral nervous system). Suppresses the aggregation of platelets.
With external application has anti-inflammatory and analgesic effect.
Reduces the morning stiffness, promotes an increase in the volume of movements in the joints.
PHARMACOKINETICS
When ingestion ibuprofen is almost completely absorbed from the digestive tract.
Simultaneous food intake slows down the rate of absorption. Metabolised in the liver (90%). T 1/2 is 2-3 hours.
80% of the dose is excreted in the urine mainly in the form of metabolites (70%), 10% - unchanged;
20% is excreted through the intestines in the form of metabolites.
INDICATIONS
Inflammatory-degenerative diseases of the joints and spine (including rheumatoid and rheumatoid arthritis, ankylosing spondylitis, osteoarthritis), articular syndrome with exacerbation of gout, psoriatic arthritis, ankylosing spondylitis, tendonitis, bursitis, sciatica, traumatic inflammation of soft tissues and musculoskeletal apparatus.
Neuralgia, myalgia, pain syndrome in infectious and inflammatory diseases of ENT organs, adnexitis, algodismenorea, headache and toothache. Fever with infectious and inflammatory diseases.
DOSING MODE
Established individually, depending on the nosological form of the disease, the severity of clinical manifestations.
When administered or rectally for adults, a single dose is 200-800 mg, the frequency of admission is 3-4 times / day; for children - 20-40 mg / kg / day in several receptions.
Apply externally for 2-3 weeks.

The maximum daily intake for adults with oral or rectal administration is 2.4 g.

SIDE EFFECT
From the digestive system: often - nausea, anorexia, vomiting, a feeling of discomfort in the epigastrium, diarrhea;
possibly the development of erosive and ulcerative gastrointestinal lesions; rarely bleeding from the digestive tract; with prolonged use may impair liver function.
From the side of the central nervous system and peripheral nervous system: often - headache, dizziness, sleep disorders, agitation, visual impairment.

On the part of the hematopoiesis system: with prolonged use, anemia, thrombocytopenia, agranulocytosis are possible.

From the side of the urinary system: with prolonged use, there may be impaired renal function.

Allergic reactions: often - skin rash, angioedema;
rarely - aseptic meningitis (more often in patients with autoimmune diseases), bronchospastic syndrome.
Local reactions: with external application, there may be skin hyperemia, a burning sensation or tingling sensations.

CONTRAINDICATIONS
Erosive-ulcerative lesions of the gastrointestinal tract in the phase of exacerbation, optic nerve disease, "aspirin triad", hematopoietic disorders, marked renal and / or liver dysfunction;
III trimester of pregnancy; hypersensitivity to ibuprofen.
PREGNANCY AND LACTATION
Application in the III trimester of pregnancy is contraindicated.
The use in the first and second trimesters of pregnancy is justified only in those cases when the expected benefit for the mother exceeds the possible risk to the fetus.
Ibuprofen in small amounts excreted in breast milk.
Use in the lactation period for pain and fever is possible. If you need long-term use or use in high doses (more than 800 mg / day), you should decide whether to stop breastfeeding.
APPLICATION FOR FUNCTIONS OF THE LIVER
Contraindicated in severe impairment of kidney function.
With caution apply with concomitant diseases of the kidneys.
APPLICATION FOR VIOLATIONS OF THE FUNCTION OF KIDNEYS
Contraindicated in severe violations of liver function.
With caution apply with concomitant liver diseases.
SPECIAL INSTRUCTIONS
With caution apply with concomitant diseases of the liver and kidneys, chronic heart failure, with dyspeptic symptoms before the start of treatment, immediately after the surgery, with history of bleeding from the digestive tract and gastrointestinal disease, allergic reactions associated with the intake of NSAIDs.

In the process of treatment, systematic monitoring of liver and kidney functions, and peripheral blood patterns are necessary.

Do not use externally on damaged areas of the skin.

DRUG INTERACTION
With the simultaneous use of ibuprofen reduces the effect of antihypertensive drugs (ACE inhibitors, beta-adrenoblockers), diuretics (furosemide, hydrochlorothiazide).

With simultaneous use with anticoagulants, it is possible to enhance their effect.

With simultaneous application with GCS, the risk of side effects from the gastrointestinal tract increases.

With the simultaneous use of ibuprofen may displace from the compounds with blood plasma proteins, indirect anticoagulants (acenocumarol), hydantoin derivatives (phenytoin), oral hypoglycemic drugs derivatives of sulfonylureas.

With simultaneous use with amlodipine, a slight decrease in the antihypertensive effect of amlodipine is possible;
with acetylsalicylic acid - the concentration of ibuprofen in blood plasma decreases; with baclofen - a case of increasing the toxic effect of baclofen is described.
With simultaneous use with warfarin, an increase in bleeding time may be possible, microhematuria, hematomas were also observed;
with captopril - it is possible to reduce the antihypertensive effect of captopril; with colestyramine - a moderate decrease in absorption of ibuprofen.
With simultaneous application of lithium carbonate, the concentration of lithium in the blood plasma increases.

With the simultaneous use of magnesium hydroxide, the initial absorption of ibuprofen increases;
with methotrexate - the toxicity of methotrexate is increased.

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