Universal reference book for medicines
Product name: ADAPALEN (ADAPALEN)

Active substance: adapalene

Type: The drug for acne treatment.
Retinoid
Manufacturer: VELFARM (Russia) produced SYNTHESIS (Russia)
Composition, form of production and packaging
?
Gel for external use 0.1% white.
100 g

adapalene 100 mg

Auxiliary substances: propylene glycol - 5 g, carbomer (carbopol) - 1.1 g, methylparaben - 0.10 g, disodium edetate - 0.1 g, poloxamer 188 - 0.2 g, phenoxyethanol - 0.25 g, sodium hydroxide - 0.2 g, purified water - up to 100 g .

15 g - plastic tubes (1) - packs of cardboard.

30 g - plastic tubes (1) - packs of cardboard.

INSTRUCTION FOR THE SPECIALIST.

Description of the drug approved by the manufacturer for the printed edition of 2011.

PHARMACHOLOGIC EFFECT

Adapalene is a metabolite of retinoid, it possesses comedonolytic and anti-inflammatory activity, it normalizes the processes of keratanization and epidermal differentiation.

The mechanism of action of adapalene is based on interaction, with specific receptors of skin epidermal cells.
As a result of the action of adapalene, in particular, the "cohesion" of epithelial cells in the mouth of the sebaceous-follicle follicle decreases and the preconditions for the formation of micro-medodons decrease. Adapalene has an anti-inflammatory effect in vivo and in vitro, affecting inflammatory factors by inhibiting the migration of leukocytes in the focus of inflammation and the metabolism of arachidonic acid.
INDICATIONS

- acne.

DOSING MODE

Outerly, applied once a day before going to sleep on clean, dry skin, evenly, lightly touching, avoiding contact with the eyes and lips.
Clinical result occurs after 4-8 weeks of treatment, persistent improvement - after 3 months of treatment.
SIDE EFFECT

Hyperemia and shelling of the skin in the place of application.

CONTRAINDICATIONS

- pregnancy, lactation;

- children's age till 12 years;

hypersensitivity.

With caution: dermatitis, seborrhea, eczema.

PREGNANCY AND LACTATION

Contraindicated in pregnancy and lactation.

APPLICATION FOR CHILDREN

Contraindicated in children under 12 years.

SPECIAL INSTRUCTIONS

If the skin irritates, stop using the gel (temporarily or completely).
Avoid staying in the sun; in the case of prolonged exposure to the sun, do not apply the gel the day before, as well as on the day of the solar exposure and the subsequent day. It is not recommended simultaneous use of cosmetic products with drying and irritating effect on the skin (for example, alcohol-containing products).
DRUG INTERACTION

Possible simultaneous administration with clindamycin or benzoyl peroxide.
Be careful when combined with drugs that have an irritant or drying effect, including
preparations containing sulfur, resorcinol or salicylic acid (possibly increasing side effects).


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