Universal reference book for medicines
Product name: ADAKLIN (ADAKLIN)

Active substance: adapalene

Type: The drug for acne treatment.
Retinoid
Manufacturer: RANBAXY LABORATORIES (India)

Description of the active substance :.
This information is a reference and it is not enough that the drug was prescribed by a doctor.
.
PHARMACHOLOGIC EFFECT
Means for external use.
Adapalene is a metabolite of retinoid, has a comedonolytic and anti-inflammatory effect, normalizes the processes of keratinization and epidermal differentiation.
The mechanism of action of adapalene is based on the interaction with specific β-receptors of epidermal skin cells.
As a result of the action of adapalene, in particular, the "cohesion" of epithelial cells in the mouth of the sebaceous-hair follicle decreases and the preconditions for the formation of micro-comedones decrease.
Adapalene has an anti-inflammatory effect in vitro and in vivo, affecting inflammatory factors by inhibiting the migration of leukocytes in the focus of inflammation and the metabolism of arachidonic acid.

PHARMACOKINETICS
Absorption of adapalene through the skin is very low (about 4% of the applied dose).
Derivation of adapalene from the body occurs mainly with bile.
INDICATIONS
Acne.

DOSING MODE
Apply externally.
Evenly applied to the affected surface 1 time / day before bedtime, avoiding contact with the mucous membranes of the eyes and lips.
The therapeutic effect develops after 4-8 weeks of treatment, persistent improvement occurs after 3 months of treatment.

SIDE EFFECT
Dermatological reactions: irritation of the skin (treatment should be stopped until skin irritation disappears or frequency of application is reduced).

CONTRAINDICATIONS
Pregnancy;
lactation period (breastfeeding); hypersensitivity to adapalene.
PREGNANCY AND LACTATION
It is not recommended to use the drug during pregnancy and lactation (breastfeeding).

SPECIAL INSTRUCTIONS
With caution should be used for dermatitis, eczema.

Avoid direct sunlight, as skin irritation may occur.
Treatment can be continued if exposure to sunlight is minimized.
It is not recommended simultaneous use of cosmetic products with drying and irritating effect on the skin (for example, perfume or ethanol-containing products).

Adapalene, applied to the skin in the evening, can be combined with drugs for the treatment of blackheads, applied in the morning.

DRUG INTERACTION
Since adapalene does not interact with oxygen and does not break down under the influence of light, it is possible to simultaneously treat acne with drugs such as clindamycin phosphate or benzoyl peroxide.

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