Universal reference book for medicines
Product name: AVOMIT (AVOMIT)

Active substance: granisetron

Type: Antagonist of serotonin 5-HT 3 -receptors.
Antiemetic drug of central action
Manufacturer: BIOKAD (Russia)
Description of the active substance :.
This information is a reference and it is not enough that the drug was prescribed by a doctor.
.
PHARMACHOLOGIC EFFECT
Antiemetic means.
Selective antagonist of serotonin 5HT 3 receptors. It suppresses vomiting that occurs when the parasympathetic nervous system is excited due to the release of serotonin by enterochromaffin cells.
PHARMACOKINETICS
After intravenous administration at doses of 20 μg / kg or 40 μg / kg, the mean C max in blood plasma is 13.7 μg / l and 42.8 μg / l, respectively.

Binding to plasma proteins - 65%.

Rapidly metabolized by demethylation and oxidation.

T 1/2 is 3.1-5.9 hours. In cancer patients, T 1/2 rises to 10-12 hours. It is excreted in urine and feces mainly in the form of conjugates;
8-15% is found in the urine in unchanged form.
INDICATIONS
Prevention and treatment of nausea and vomiting in chemotherapy with cytostatics.

Prevention and treatment of postoperative nausea and vomiting.

DOSING MODE
Adults for oral administration of a single dose of 1 mg, for intravenous infusion a single dose of 3 mg, for intravenous injection (slowly, at least 30 seconds), a single dose of 1 mg.

The maximum dose is 9 mg / day.

Children in / in drip singly - 40 mkg / kg (but not more than 3 mg).
Children older than 12 years for oral administration of a single dose of 1 mg.
Multiplicity and duration of application are set individually.

SIDE EFFECT
Perhaps: a transient increase in hepatic transaminase activity in the blood, constipation, headache, skin rash.

CONTRAINDICATIONS
Hypersensitivity to granisetron.

PREGNANCY AND LACTATION
The safety of treatment with granisetron during pregnancy is not established, therefore application is possible only in cases of extreme necessity.
If necessary, use during lactation should stop breastfeeding.
APPLICATION FOR CHILDREN
For the treatment and prevention of postoperative nausea and vomiting in children, granisetron is not used.

SPECIAL INSTRUCTIONS
With caution apply for symptoms of impaired intestinal permeability.

For the treatment and prevention of postoperative nausea and vomiting in children, granisetron is not used.

TERMS AND CONDITIONS OF STORAGE
[MSK] 01.04 in the RK is not registered.


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